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pro vyhledávání: '"Hirotsugu Yokoi"'
Autor:
Hirotsugu Yokoi, Ryuichi Tsujita, Masahiro Saitoh, Toshiyuki Kodama, Yuji Ohtsuka, Takashi Kubota, Kenji Naganuma, Junji Nakamura, Naoto Ohkawa, Masayoshi Takemura, Masashi Kawanishi, Akifumi Omura, Hiromitsu Nagumo, Naomi Maekawara, Koh Kawasaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3174-3176
In this study the first PDE4B selective inhibitor is described. Optimization of lead 2-arylpyrimidine derivatives afforded a series of potent PDE4B inhibitors with >100-fold selectivity over the PDE4D isozyme. With a good pharmacokinetic profile, a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c5d21651e4ef7eb5286012e998d3b1
https://doi.org/10.1016/j.bmcl.2009.04.121
https://doi.org/10.1016/j.bmcl.2009.04.121
