Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hirotsugu Tanaka"'
Autor:
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTNerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons. Although anti-NGF antibodies im
Externí odkaz:
https://doaj.org/article/1d317d9198cb4f5ca6596cc78d7ab4ae
Autor:
Akira Yamashita, Yuichi Shichino, Hirotsugu Tanaka, Edwige Hiriart, Leila Touat-Todeschini, Aurélia Vavasseur, Da-Qiao Ding, Yasushi Hiraoka, André Verdel, Masayuki Yamamoto
Publikováno v:
Open Biology, Vol 2, Iss 3 (2012)
The selective elimination system blocks the accumulation of meiosis-specific mRNAs during the mitotic cell cycle in fission yeast. These mRNAs harbour a region, the determinant of selective removal (DSR), which is recognized by a YTH-family RNA-bindi
Externí odkaz:
https://doaj.org/article/c35987d7a00b4565b59cff0585e69d64
Autor:
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara
Publikováno v:
mAbs. 15
Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons. Although anti-NGF antibodies improve pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dab9b9a7d7ce59e3a7ddec62b8af58
https://doi.org/10.1080/19420862.2022.2149055
https://doi.org/10.1080/19420862.2022.2149055
Autor:
Fumiyoshi Iwasaki, Takao Yamazaki, Masayuki Shibasaki, Tetsuo Matsui, Hirotsugu Tanaka, Hideaki Minoura, Shigeru Yoshida, Hiroyuki Oshima, Kenji Negoro, Shuichi Sakuda
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:443-452
GPR40 is a free fatty acid receptor that has been shown to regulate glucose-dependent insulin secretion. This study aimed to discover novel GPR40 agonists and investigate the whole-body effect on glucose metabolism of GPR40 activation using these nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6a9706202a1d1a7f377e5b3a534ee3
https://doi.org/10.1124/jpet.113.206466
https://doi.org/10.1124/jpet.113.206466
Autor:
Yasuo Uchiyama, Yasuhiro Yonetoku, Hirotsugu Tanaka, Takahide Ohishi, Hiroyuki Oshima, Shigeru Yoshida, Tetsuo Matsui, Masayuki Shibasaki
Publikováno v:
Life Sciences. 92:167-173
Aims G-protein-coupled receptor 119 (GPR119), mainly expressed in pancreatic β-cells, represents a new target for treating type 2 diabetes. GPR119 agonist is known to induce insulin secretion in a glucose-dependent manner by elevating intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad2646b34eefcdfa9dcbdcd2ed4bc1b
https://doi.org/10.1016/j.lfs.2012.11.015
https://doi.org/10.1016/j.lfs.2012.11.015
Autor:
Tetsuo Matsui, Hirotsugu Tanaka, Satoshi Yoshida, Masayuki Shibasaki, Takahide Ohishi, Yasuhiro Yonetoku, Hiroyuki Oshima
Publikováno v:
Diabetes, Obesity and Metabolism. 13:34-41
Aim: AS1535907, a small molecule agonist of GPR119, was assessed for its glucose-stimulated insulin secretory activity and pancreatic β-cell function in type 2 diabetes. Methods: Both in vitro and in vivo tests were conducted using NIT-1 and HEK293
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fe9402c6298729a6874fedef7a3a41
https://doi.org/10.1111/j.1463-1326.2010.01315.x
https://doi.org/10.1111/j.1463-1326.2010.01315.x
Autor:
Hirotsugu Tanaka, Masayuki Shibasaki, Yasuhiro Yonetoku, Takahide Ohishi, Shigeru Yoshida, Hiroyuki Oshima, Tetsuo Matsui
Publikováno v:
Biochemical and Biophysical Research Communications. 402:280-285
G protein-coupled receptor (GPR) 119 is highly expressed in pancreatic β-cells and enhances the effect of glucose-stimulated insulin secretion (GSIS) on activation. The development of an oral GPR119 agonist that specifically targets the first phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259ba6df4687fae7e346a9c3ff11e20e
https://doi.org/10.1016/j.bbrc.2010.10.015
https://doi.org/10.1016/j.bbrc.2010.10.015
Autor:
Akiyoshi Shimaya, Masayuki Shibasaki, Yasuharu Urano, Takeyuki Nagashima, Hirotsugu Tanaka, Teruhiko Shimokawa
Publikováno v:
European Journal of Pharmacology. 645:185-191
Recent evidence suggests that the forkhead transcription factor Foxo1 plays an important role in the regulation of glucose and triglyceride metabolism at the gene transcription level for glucose-6 phosphatase (G6Pase), phosphoenolpyruvate carboxykina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298aca6e08c296a4ce1b30dc7a9944c2
https://doi.org/10.1016/j.ejphar.2010.07.018
https://doi.org/10.1016/j.ejphar.2010.07.018
Autor:
Masayuki Shibasaki, Hideaki Minoura, Hirotsugu Tanaka, Akiyoshi Shimaya, Teruhiko Shimokawa, Kenji Negoro, Shigeru Yoshida
Publikováno v:
Life sciences. 94(2)
Aims GPR40 is a free fatty acid receptor that regulates glucose-dependent insulin secretion at pancreatic β-cells and glucagon-like peptide-1 (GLP-1), one of the major incretins, secretion at the endocrine cells of the gastrointestinal tract. We inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37da1f762dbcd75347a977730b17ef24
https://pubmed.ncbi.nlm.nih.gov/24269216
https://pubmed.ncbi.nlm.nih.gov/24269216
Autor:
Masayuki Shibasaki, Takahide Ohishi, Yasuhiro Yonetoku, Shigeru Yoshida, Hiroyuki Oshima, Hirotsugu Tanaka, Takao Yamazaki, Tetsuo Matsui
Publikováno v:
Biochemical and biophysical research communications. 400(4)
G-protein-coupled receptor (GPR) 119 is involved in glucose-stimulated insulin secretion (GSIS) and represents a promising target for the treatment of type 2 diabetes as it is highly expressed in pancreatic β-cells. Although a number of oral GPR119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a132ebcaac6a004262ce122e6f5461c
https://pubmed.ncbi.nlm.nih.gov/20816753
https://pubmed.ncbi.nlm.nih.gov/20816753