Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hirotsugu, Hino"'
Autor:
Toshikatsu Ikeda, Yuki Katoh, Hirotsugu Hino, Daichi Seta, Tadashi Ogawa, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Shuichi Hirai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Stearoyl-CoA desaturase 1 (SCD1) is an attractive target for cancer therapy. However, the clinical efficacy of SCD1 inhibitor monotherapy is limited. There is thus a need to elucidate the mechanisms of resistance to SCD1 inhibition and devel
Externí odkaz:
https://doaj.org/article/f3aa575b4baa416fbc0f3b6f8f9c264e
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101705- (2024)
(Macro)autophagy is a cellular degradation system for unnecessary materials, such as aggregate-prone TDP-43, a central molecule in neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Abemaciclib (
Externí odkaz:
https://doaj.org/article/6e41ffab52e64792978198969ecabe96
Autor:
Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyper-inflammatory disorder. The mortality of HLH is higher in the elderly than in young adults. Senescence-accelerated mice (SAMP1/TA-1) exhibit characteristic accelera
Externí odkaz:
https://doaj.org/article/035b3c59f87d46d493245ef75060b768
Autor:
Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/00b3bbb8cd044e8baf6fb9baafd862b3
Autor:
Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin
Externí odkaz:
https://doaj.org/article/2b53b82c6ae5403ab382220048b0b353
Autor:
Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa
Publikováno v:
British Journal of Cancer. 128:1838-1849
Background Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b0504bf8c1dce1a1821fa8c6646c1d
https://doi.org/10.1038/s41416-023-02210-4
https://doi.org/10.1038/s41416-023-02210-4
Autor:
Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) induce autophagy in epidermal growth factor receptor (EGFR) knock-out A549 and non-BCR-ABL-expressing leu
Externí odkaz:
https://doaj.org/article/c639655190624e29aa720337aaa658e3
Autor:
Miyuki Yuda, Shin Aizawa, Isao Tsuboi, Yoko Hirabayashi, Tomonori Harada, Hirotsugu Hino, Shuichi Hirai
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1602-1608
Lipopolysaccharide (LPS) treatment induced hemophagocytic lymphohistiocytosis in senescence-accelerated mice (SAMP1/TA-1), but not in senescence-resistant control mice (SAMR1). SAMP1/TA-1 treated with LPS exhibited functional impairment of the hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717db705cf91e2e6735898c1f2cd612f
https://doi.org/10.1248/bpb.b22-00108
https://doi.org/10.1248/bpb.b22-00108
Publikováno v:
Biochemical and Biophysical Research Communications. 614:191-197
Macroautophagy (hereafter autophagy) is a conserved cellular degradation system, impairments in which have been implicated in the development of a wide range of diseases, including cancer and neurodegenerative diseases. Autophagy is mainly comprised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f267b18373beff7120230a6059b54876
https://doi.org/10.1016/j.bbrc.2022.05.027
https://doi.org/10.1016/j.bbrc.2022.05.027
Autor:
Masaki Hiramoto, Keisuke Miyazawa, Akihisa Abe, Hiroko Kokuba, Shota Moriya, Atsuo Takeda, Kiyoaki Tsukahara, Hirotsugu Hino, Naoharu Takano
Publikováno v:
International Journal of Oncology
The proton pump inhibitor lansoprazole (LPZ) inhibits the growth of several cancer cell lines, including A549 and CAL 27. We previously reported that macrolide antibiotics such as azithromycin (AZM) and clarithromycin (CAM) potently inhibit autophagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8d6f2ada77ba30f64072600dbdd261
http://europepmc.org/articles/PMC7646592
http://europepmc.org/articles/PMC7646592