Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Hiroto Ohguchi"'
Autor:
Yasuyo Ohguchi, Hiroto Ohguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4079 (2023)
Recent studies have revealed the genetic aberrations involved in the initiation and progression of various cancers, including multiple myeloma (MM), via next-generation sequencing analysis. Notably, DIS3 mutations have been identified in approximatel
Externí odkaz:
https://doaj.org/article/f3da7ec0a08244beb049f480dfae53de
Autor:
Tadahito Yasuda, Mayu Koiwa, Atsuko Yonemura, Keisuke Miyake, Ryusho Kariya, Sho Kubota, Takako Yokomizo-Nakano, Noriko Yasuda-Yoshihara, Tomoyuki Uchihara, Rumi Itoyama, Luke Bu, Lingfeng Fu, Kota Arima, Daisuke Izumi, Shiro Iwagami, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hiroto Ohguchi, Seiji Okada, Keisuke Matsusaki, Goro Sashida, Akiko Takahashi, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108779- (2021)
Summary: In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated secretory phenotype (SASP) leads to cancer progress
Externí odkaz:
https://doaj.org/article/3ca48152ebfc477bbbd863180a470749
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 10, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/bcf6c54abc6d44dbba8826b36e8213ee
Autor:
Nao Nagai, Hiroto Ohguchi, Ryo Nakaki, Yoshihiro Matsumura, Yasuharu Kanki, Juro Sakai, Hiroyuki Aburatani, Takashi Minami
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007826 (2018)
Endothelial cell (EC) plasticity in pathological settings has recently been recognized as a driver of disease progression. Endothelial-to-mesenchymal transition (EndMT), in which ECs acquire mesenchymal properties, has been described for a wide range
Externí odkaz:
https://doaj.org/article/9e6b0d10b4f545b39642a6a2e4f4a700
Autor:
Hiroto Ohguchi, Teru Hideshima, Manoj K. Bhasin, Gullu T. Gorgun, Loredana Santo, Michele Cea, Mehmet K. Samur, Naoya Mimura, Rikio Suzuki, Yu-Tzu Tai, Ruben D. Carrasco, Noopur Raje, Paul G. Richardson, Nikhil C. Munshi, Hideo Harigae, Takaomi Sanda, Juro Sakai, Kenneth C. Anderson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Several histone modifiers have been implicated in the survival of multiple myeloma cells. Here, the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer, and show that mechanistically KDM3A removes H3K9
Externí odkaz:
https://doaj.org/article/20b2f18e02d546e98af32ec37b4cedf8
Autor:
Rikio Suzuki, Shohei Kikuchi, Takeshi Harada, Naoya Mimura, Jiro Minami, Hiroto Ohguchi, Yasuhiro Yoshida, Morihiko Sagawa, Gullu Gorgun, Diana Cirstea, Francesca Cottini, Jana Jakubikova, Yu-Tzu Tai, Dharminder Chauhan, Paul G Richardson, Nikhil Munshi, Kiyoshi Ando, Teruhiro Utsugi, Teru Hideshima, Kenneth C Anderson
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143847 (2015)
Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor TAS-116 shows significant
Externí odkaz:
https://doaj.org/article/83ce039a22d7489a9099eed0350d4025
Autor:
Jun Qi, Teru Hideshima, Kenneth C. Anderson, Adam D. Durbin, Udo Oppermann, Javed Khan, Shannon Lauberth, Takashi Minami, Mitsuyoshi Nakao, Sumio Ohtsuki, Masao Matsuoka, Nikhil C. Munshi, Yu-Tzu Tai, Mehmet K. Samur, Yawara Kawano, Shingo Usuki, Shinjiro Hino, Yong Kim, Virangika K. Wimalasena, Catrine Johansson, Takeshi Masuda, Chengkui Pei, Deyao Li, Xiaofeng Zhang, Keiji Kurata, Daisuke Ogiya, Berkley E. Gryder, Tingjian Wang, Paul M.C. Park, Hiroto Ohguchi
Supplementary Figure S2 shows the selectivity of JQKD82 against KDM5 in biochemical assay and in MM cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e164ba894a77028c52bc91851584ba6
https://doi.org/10.1158/2643-3230.22544002
https://doi.org/10.1158/2643-3230.22544002
Autor:
Jun Qi, Teru Hideshima, Kenneth C. Anderson, Adam D. Durbin, Udo Oppermann, Javed Khan, Shannon Lauberth, Takashi Minami, Mitsuyoshi Nakao, Sumio Ohtsuki, Masao Matsuoka, Nikhil C. Munshi, Yu-Tzu Tai, Mehmet K. Samur, Yawara Kawano, Shingo Usuki, Shinjiro Hino, Yong Kim, Virangika K. Wimalasena, Catrine Johansson, Takeshi Masuda, Chengkui Pei, Deyao Li, Xiaofeng Zhang, Keiji Kurata, Daisuke Ogiya, Berkley E. Gryder, Tingjian Wang, Paul M.C. Park, Hiroto Ohguchi
Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3 lysine 4 trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We identify that KDM5A interacts with the P-TEFb complex and cooperates with MYC to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e2d62b9170ea08c3ca5fb596a64ef6
https://doi.org/10.1158/2643-3230.c.6550489.v1
https://doi.org/10.1158/2643-3230.c.6550489.v1
Autor:
Jun Qi, Teru Hideshima, Kenneth C. Anderson, Adam D. Durbin, Udo Oppermann, Javed Khan, Shannon Lauberth, Takashi Minami, Mitsuyoshi Nakao, Sumio Ohtsuki, Masao Matsuoka, Nikhil C. Munshi, Yu-Tzu Tai, Mehmet K. Samur, Yawara Kawano, Shingo Usuki, Shinjiro Hino, Yong Kim, Virangika K. Wimalasena, Catrine Johansson, Takeshi Masuda, Chengkui Pei, Deyao Li, Xiaofeng Zhang, Keiji Kurata, Daisuke Ogiya, Berkley E. Gryder, Tingjian Wang, Paul M.C. Park, Hiroto Ohguchi
Supplementary Table S2 shows the ChIP-seq data with the peaks significantly overlap with KDM5A ChIP-seq peaks MM1S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77999a99375efd465960396dc9d44e02
https://doi.org/10.1158/2643-3230.22543981.v1
https://doi.org/10.1158/2643-3230.22543981.v1
Autor:
Jun Qi, Teru Hideshima, Kenneth C. Anderson, Adam D. Durbin, Udo Oppermann, Javed Khan, Shannon Lauberth, Takashi Minami, Mitsuyoshi Nakao, Sumio Ohtsuki, Masao Matsuoka, Nikhil C. Munshi, Yu-Tzu Tai, Mehmet K. Samur, Yawara Kawano, Shingo Usuki, Shinjiro Hino, Yong Kim, Virangika K. Wimalasena, Catrine Johansson, Takeshi Masuda, Chengkui Pei, Deyao Li, Xiaofeng Zhang, Keiji Kurata, Daisuke Ogiya, Berkley E. Gryder, Tingjian Wang, Paul M.C. Park, Hiroto Ohguchi
Supplementary Methods, compound synthesis, Supplementary Materials and Supplementary References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ff6a7d3836bc266c36040203fb6498
https://doi.org/10.1158/2643-3230.22543987
https://doi.org/10.1158/2643-3230.22543987