Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hiroto Kiguchi"'
Autor:
Daniel E. Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A. Boyer, Daniel R. Boué, Matija Snuderl, Matthew B. Greenblatt, Yosi Shamay, G. Praveen Raju, Daniel A. Heller
Publikováno v:
Nature Materials. 22:391-399
Medulloblastoma is the most common malignant paediatric brain tumour, with ~30% mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic hedgehog effector Smoothened inhibits tumour growth but causes growth plate fusion at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1d70af9c05cc7c2ec3b92c55ca03fc
https://doi.org/10.1038/s41563-023-01481-9
https://doi.org/10.1038/s41563-023-01481-9
Autor:
Mandana T. Manzari, Hiroto Kiguchi, Laurie Herviou, Mariana da Silva Ferreira, Daniel A. Heller, Katia Manova-Todorova, Anas Younes, Connor J Hagen, Elisa de Stanchina, Neeta Bala Tannan, Venkatraman E. Seshan
Publikováno v:
Blood
Cancer and normal cells use multiple antiapoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing but is also associated with increased systemic toxicity. Here, we demonstrate that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4972181b4069da8c1c5d58d129ca4f
https://doi.org/10.1182/blood.2020008017
https://doi.org/10.1182/blood.2020008017
Autor:
Daniel A. Heller, Maurizio Scaltriti, Hiroto Kiguchi, Mandana T. Manzari, Yosi Shamay, Neal Rosen
Publikováno v:
Nat Rev Mater
Progress in the field of precision medicine has changed the landscape of cancer therapy. Precision medicine is propelled by technologies that enable molecular profiling, genomic analysis and optimized drug design to tailor treatments for individual p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77861143d14e79d8bff26167057c0ef
https://doi.org/10.1038/s41578-020-00269-6
https://doi.org/10.1038/s41578-020-00269-6
Autor:
Hiroto Kiguchi, Mandana Manzari, Jake Vaynshteyn, Jeffrey Gerwin, Daniel Tylawsky, Na Li, Janki Shah, Yosi Shamay, Matthew Greenblatt, Daniel Heller, G Praveen Raju
Publikováno v:
Neuro Oncol
OBJECTIVE The Sonic Hedgehog (SHH) medulloblastoma subgroup accounts for ~25% of all cases and has an intermediate prognosis. Current conventional therapies result in devastating morbidities including intellectual disability and secondary malignancie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875c5984b4aa4bca157751c857ed738
https://europepmc.org/articles/PMC6846632/
https://europepmc.org/articles/PMC6846632/
Medulloblastoma, the most common pediatric malignant brain tumor, is divided into at least four molecular subtypes. The Sonic Hedgehog (SHH) subtype, accounts for approximately 30% of all cases and has an intermediate prognosis (5-year overall surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d852e495cb256db1d950a7a55c0252
https://europepmc.org/articles/PMC6012769/
https://europepmc.org/articles/PMC6012769/
Publikováno v:
Pediatric Blood & Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b1a7c3c08bbc9875f0efd735b9a80a
https://doi.org/10.1002/pbc.27057
https://doi.org/10.1002/pbc.27057
Autor:
Manzari, Mandana T., Shamay, Yosi, Kiguchi, Hiroto, Rosen, Neal, Scaltriti, Maurizio, Heller, Daniel A.
Publikováno v:
Nature Reviews Materials; Apr2021, Vol. 6 Issue 4, p351-370, 20p
Publikováno v:
Pediatric Blood & Cancer; Jun2018 Supplement S1, Vol. 65, p1-1, 301p
Autor:
Hiroto S. Watanabe
This book analyzes advances in cancer research. Chapter 1 will highlight the main features regarding the most outstanding contributions around stimuli-responsive lipid-based nanovesicles and the recent advances in their biomedical applications in can