Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hirotake Komatsu"'
Autor:
Hiroyuki Kato, Mayra Salgado, Daniel Mendez, Nelson Gonzalez, Jeffrey Rawson, Doreen Ligot, Bennie Balandran, Chris Orr, Janine C. Quijano, Keiko Omori, Meirigeng Qi, Ismail H. Al-Abdullah, Yoko Mullen, Hsun Teresa Ku, Fouad Kandeel, Hirotake Komatsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Evaluating the quality of isolated human islets before transplantation is crucial for predicting the success in treating Type 1 diabetes. The current gold standard involves time-intensive in vivo transplantation into diabetic immunodeficient
Externí odkaz:
https://doaj.org/article/e4c92950caa44443bef83e5c39527a56
Autor:
Hiroyuki Kato, Huajian Chen, Kuang-Ming Shang, Kenji Izumi, Naoya Koba, Takanori Tsuchiya, Naoki Kawazoe, Janine Quijano, Keiko Omori, Chris Orr, Meirigeng Qi, Hsun Teresa Ku, Fouad Kandeel, Yu-Chong Tai, Guoping Chen, Hirotake Komatsu
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Pancreatic islet transplantation is one of the clinical options for certain types of diabetes. However, difficulty in maintaining islets prior to transplantation limits the clinical expansion of islet transplantations. Our study introduces a dynamic
Externí odkaz:
https://doaj.org/article/5bd294cb3a824e56a8d2d219d5f74665
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Fireflies produce light through luciferase-catalyzed reactions involving luciferin, oxygen, and adenosine triphosphate, distinct from other luminescent organisms. This unique feature has revolutionized molecular biology and physiology, serving as a v
Externí odkaz:
https://doaj.org/article/d019e00953c1424ea1dfee59184622ef
Autor:
Nelson Gonzalez, Hiroyuki Kato, Wilma Tixi, Jose Ortiz, Chris Orr, Hung-Ping Shih, Hsun Teresa Ku, Jiing-Kuan Yee, Fouad Kandeel, Yoko Mullen, Eiji Kobayashi, Hirotake Komatsu
Publikováno v:
Cell Transplantation, Vol 32 (2023)
“Firefly rats” ubiquitously express the luciferase reporter gene under the control of constitutively active ROSA26 promoter in inbred Lewis rats. Due to the minimal immunogenicity of luciferase, wide applications of Firefly rats have been reporte
Externí odkaz:
https://doaj.org/article/d9939e4fbe0148df8740c480b1a26889
Autor:
Hiroyuki Kato, Tatsuaki Miwa, Janine Quijano, Leonard Medrano, Jose Ortiz, Akiko Desantis, Keiko Omori, Aya Wada, Kentaro Tatsukoshi, Fouad Kandeel, Yoko Mullen, Hsun Teresa Ku, Hirotake Komatsu
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundTransplantation of the human pancreatic islets is a promising approach for specific types of diabetes to improve glycemic control. Although effective, there are several issues that limit the clinical expansion of this treatment, including d
Externí odkaz:
https://doaj.org/article/464c9420acd848cba8fbb35c40f514de
Autor:
Hirotake Komatsu MD, PhD, Meirigeng Qi MD, PhD, Nelson Gonzalez, Mayra Salgado, Leonard Medrano, Jeffrey Rawson, Chris Orr PhD, Keiko Omori MD, PhD, Jeffrey S. Isenberg MD, MPH, Fouad Kandeel MD, PhD, Yoko Mullen MD, PhD, Ismail H. Al-Abdullah PhD
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Prior to transplantation into individuals with type 1 diabetes, in vitro assays are used to evaluate the quality, function and survival of isolated human islets. In addition to the assessments of these parameters in islet, they can be evaluated by mu
Externí odkaz:
https://doaj.org/article/0f4ff8cb9b0b4e068b33d8fc6e8c5b57
Autor:
Keiko Omori, Ignacio Gonzalez, Cindy Nguyen, Shanti N. Raminani, Victor M. Deleon, Pedro Meza, Jose Zamalloa, Rachel G. Perez, Nelson Gonzalez, Hirotake Komatsu, Ismail H. Al-Abdullah, Xin Wen
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1584 (2022)
Hypothermic (cold) preservation is a limiting factor for successful cell and tissue transplantation where cell swelling (edema) usually develops, impairing cell function. University of Wisconsin (UW) solution, a standard cold preservation solution, c
Externí odkaz:
https://doaj.org/article/88e5dee383cb482084f32a27961b8136
Autor:
Junfeng Li, Hirotake Komatsu, Erasmus K. Poku, Tove Olafsen, Kelly X. Huang, Lina A. Huang, Junie Chea, Nicole Bowles, Betty Chang, Jeffrey Rawson, Jiangling Peng, Anna M. Wu, John E. Shively, Fouad R. Kandeel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 595 (2022)
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-MSC-EVs) have become an emerging strategy for treating various autoimmune and metabolic disorders, particularly diabetes. Delivery of UC-MSC-EVs is essential to ensure optimal ef
Externí odkaz:
https://doaj.org/article/fc5d815ac8214fe2a4665d2d91fb950d
Autor:
Mayra Salgado, Nelson Gonzalez, Leonard Medrano, Jeffrey Rawson, Keiko Omori, Meirigeng Qi, Ismail Al-Abdullah, Fouad Kandeel, Yoko Mullen, Hirotake Komatsu
Publikováno v:
Cell Transplantation, Vol 29 (2020)
In clinical and experimental human pancreatic islet transplantations, establishing pretransplant assessments that accurately predict transplantation outcomes is crucial. Conventional in vitro viability assessment that relies on manual counting of via
Externí odkaz:
https://doaj.org/article/c7cb8a39c60b45a99de58012b10d4783
Autor:
Hirotake Komatsu, Colin Cook, Chia-Hao Wang, Leonard Medrano, Henry Lin, Fouad Kandeel, Yu-Chong Tai, Yoko Mullen
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183780 (2017)
Type 1 diabetes is an autoimmune disease that destroys insulin-producing beta cells in the pancreas. Pancreatic islet transplantation could be an effective treatment option for type 1 diabetes once several issues are resolved, including donor shortag
Externí odkaz:
https://doaj.org/article/324266794bff4b00a8a09a27252ef884