Výsledky vyhledávání - "Hirotake Imanishi"

Akademický článek

Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.

Autor: Takayuki Mito, Yoshiaki Kikkawa, Akinori Shimizu, Osamu Hashizume, Shun Katada, Hirotake Imanishi, Azusa Ota, Yukina Kato, Kazuto Nakada, Jun-Ichi Hayashi

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55789 (2013)

Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accele

Externí odkaz: https://doaj.org/article/26e751ffb9a34aad969369972af64f56

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Akademický článek

Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.

Autor: Hirotake Imanishi, Gaku Takibuchi, Toshihiko Kobayashi, Kaori Ishikawa, Kazuto Nakada, Masayuki Mori, Yoshiaki Kikkawa, Keizo Takenaga, Noriko Toyama-Sorimachi, Jun-Ichi Hayashi

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75981 (2013)

In mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg e

Externí odkaz: https://doaj.org/article/3f956d1b06b14a1ea8aabea631650e76

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Akademický článek

Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.

Autor: Hirotake Imanishi, Keisuke Hattori, Reiko Wada, Kaori Ishikawa, Sayaka Fukuda, Keizo Takenaga, Kazuto Nakada, Jun-ichi Hayashi

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23401 (2011)

Mutations in mitochondrial DNA (mtDNA) might contribute to expression of the tumor phenotypes, such as metastatic potential, as well as to aging phenotypes and to clinical phenotypes of mitochondrial diseases by induction of mitochondrial respiration

Externí odkaz: https://doaj.org/article/e48ab5ea89ea426abd8f6f6c11e142d6

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Selection of Rodent Species Appropriate for mtDNA Transfer to Generate Transmitochondrial Mito-Mice Expressing Mitochondrial Respiration Defects

Autor: Hitoshi Suzuki, Kazuto Nakada, Chisato Hayashi, Shunkei Enoki, Hirotake Imanishi, Tetsuo Hashimoto, Akinori Shimizu, Kazuyuki Mekada, Jun-Ichi Hayashi, Osamu Hashizume

Publikováno v: Experimental Animals

Previous reports have shown that transmitochondrial mito-mice with nuclear DNA from Mus musculus and mtDNA from M. spretus do not express respiration defects, whereas those with mtDNA from Rattus norvegicus cannot be generated from ES cybrids with mt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5ed9e04ebd9f18f259657e72409f73
http://europepmc.org/articles/PMC4160931

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Regulation of metastasis; mitochondrial DNA mutations have appeared on stage

Autor: Hirotake Imanishi, Keizo Takenaga, Jun-Ichi Hayashi, Kaori Ishikawa

Publikováno v: Journal of Bioenergetics and Biomembranes. 44:639-644

It has been controversial whether mtDNA mutations are responsible for tumorigenesis and for the process to develop metastases. To clarify this issue, we established trans-mitochondrial cybrids with mtDNA exchanged between mouse tumor cells that posse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12524dcc8a0c963758618a8d787662dd
https://doi.org/10.1007/s10863-012-9468-6

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Nuclear but Not Mitochondrial DNA Involvement in Respiratory Complex I Defects Found in Senescence-Accelerated Mouse Strain, SAMP8

Autor: Jun-Ichi Hayashi, Kazuto Nakada, Masayuki Mori, Hirotake Imanishi, Akinori Shimizu, Mutsumi Yokota

Publikováno v: Experimental Animals. 60:397-404

This study determined pathogenicity of an A11181G mtDNA mutation found in a senescence-accelerated mouse strain, SAMP8. The mutation was at a highly conserved site of the mt-Nd4 gene, which encodes one of the respiratory complex I subunits. The young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ad0633d853aa7b2067398c49f0238c
https://doi.org/10.1538/expanim.60.397

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The innate immune system in host mice targets cells with allogenic mitochondrial DNA

Autor: Jun-Ichi Hayashi, Hiromichi Yonekawa, Hirotake Imanishi, Kaori Ishikawa, Keizo Takenaga, Noriko Toyama-Sorimachi, Shigemi Sasawatari, Mamoru Niikura, Mariko Yoshizaki, Mami Morimoto, Kazuto Nakada

Publikováno v: The Journal of Experimental Medicine

Tumors or embryonic stem cells bearing foreign mitochondrial DNA are rejected by the innate immune system via a mechanism that depends on MyD88.
Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d828180c2c03af97e6ccc13b50a6e3
http://ir.lib.shimane-u.ac.jp/53963

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ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

Autor: Nobuko Koshikawa, Aya Yamaguchi, Keizo Takenaga, Hirotake Imanishi, Yoshio Honma, Miho Akimoto, Kazuto Nakada, Jun-Ichi Hayashi, Kaori Ishikawa

Publikováno v: Science. 320:661-664

Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but whether these mutations alter tumor cell behavior has been unclear. We used cytoplasmic hybrid (cybrid) technology to replace the endogenous mtDNA in a mouse tumor ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f0f4af15adcb49d5e7e5bfc7876c32
https://doi.org/10.1126/science.1156906

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Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system

Autor: Kaori Ishikawa, Gaku Takibuchi, Kazuto Nakada, Toshihiko Kobayashi, Jun-Ichi Hayashi, Noriko Toyama-Sorimachi, Yoshiaki Kikkawa, Masayuki Mori, Hirotake Imanishi, Keizo Takenaga

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75981 (2013)

mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glycolysis under normoxic conditions (the Warburg effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ee9af0d2fed4a6981d38489ecf68f9
https://pubmed.ncbi.nlm.nih.gov/24098752

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Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development

Autor: Yoshiaki Kikkawa, Akinori Shimizu, Shun Katada, Jun-Ichi Hayashi, Takayuki Mito, Hirotake Imanishi, Osamu Hashizume, Yukina Kato, Kazuto Nakada, Azusa Ota

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e55789 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d9bf818344cc5e446aa9b1055f4f36
https://pubmed.ncbi.nlm.nih.gov/23418460

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