Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hirotake Ichise"'
Publikováno v:
Cells, Vol 13, Iss 7, p 582 (2024)
Human adipose-derived stromal cells (ADSCs) are an important resource for cell-based therapies. However, the dynamics of ADSCs after transplantation and their mechanisms of action in recipients remain unclear. Herein, we generated genetically enginee
Externí odkaz:
https://doaj.org/article/7f07a6e6ccfa406cbf72270e23cbefd3
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150521 (2016)
Phospholipase Cγ2 (PLCγ2)-deficient mice exhibit misconnections of blood and lymphatic vessels, and male infertility. However, the cell type responsible for vascular partitioning and the mechanism for male infertility remain unknown. Accordingly, w
Externí odkaz:
https://doaj.org/article/51e44145087844ad9889324cd3450b65
Publikováno v:
The Journal of Pathology. 249:39-51
CREB-binding protein (CBP) and p300 have oncogenic properties; both co-operate with pro-oncogenic transcription factors downstream of Ras-Erk signalling to support cell proliferation. By contrast, missense, truncating and in-frame mutations of CBP/p3
Autor:
Keisuke Yanagida, Karen Berman de Ruiz, Constantinos M. Mikelis, Racheal G Akwii, Timothy Hla, Boksik Cha, Xin Geng, Hirotake Ichise, Dongwon Choi, Hong Chen, Riaj Mahamud, Lijuan Chen, Yen-Chun Ho, R. Sathish Srinivasan, Joshua D. Wythe
Publikováno v:
JCI Insight
During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to circulating lymph, as they are not lumenized. In contrast, LECs that t
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51639 (2012)
Modulation of VEGFR-3 expression is important for altering lymphatic endothelial cell (LEC) characteristics during the lymphangiogenic processes that occur under developmental, physiological, and pathological conditions. However, the mechanisms under
Externí odkaz:
https://doaj.org/article/3345cd8282ef4d2998a3efbfb2ab747d
Autor:
Nobuaki Yoshida, Taeko Ichise, Yumi Kanegae, Saki Kondo, Hirotake Ichise, Akiko Hori, Seiji Shiozawa, Izumu Saito
Publikováno v:
ResearcherID
Experimental Animals
Experimental Animals
Temporal genetic modification of mice using the ligand-inducible Cre/loxP system is an important technique that allows the bypass of embryonic lethal phenotypes and access to adult phenotypes. In this study, we generated a tamoxifen-inducible Cre-dri
Publikováno v:
genesis. 52:440-450
The introduction of a transgene into the genome through homologous recombination or sequence-specific enzymatic modification is a key technique for producing transgenic mice. The Rosa26 gene has been widely used to produce transgenic mice because the
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150521 (2016)
PLoS ONE
PLoS ONE
Phospholipase Cγ2 (PLCγ2)-deficient mice exhibit misconnections of blood and lymphatic vessels, and male infertility. However, the cell type responsible for vascular partitioning and the mechanism for male infertility remain unknown. Accordingly, w
Autor:
Hirotake Ichise, Reiko Sakamoto, Nobuaki Yoshida, Yosuke Funato, Hiroshi Nojima, Daisuke Okuzaki, Takeshi Terabayashi, Hiroaki Miki
Publikováno v:
Current Biology. 20(21):1945-1952
SummaryOverexpression of Dishevelled (Dvl), an essential component of the Wnt signaling pathway, is frequently associated with tumors [1, 2], and thus the Dvl protein level must be tightly controlled to sustain Wnt signaling without causing tumors. K
Publikováno v:
Development. 136:191-195
The lymphatic vasculature originates from the blood vasculature through a mechanism relying on Prox1 expression and VEGFC signalling, and is separated and kept separate from the blood vasculature in a Syk- and SLP76-dependent manner. However, the mec