Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Hirotake, Mizutani"'
Autor:
Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani
Publikováno v:
Journal of Medicinal Chemistry. 64:6902-6923
Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferon production upon infection with intracellular pathogens. STING activation can promote increased T-cell activation and inflammation in the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442f
https://doi.org/10.1021/acs.jmedchem.1c00374
https://doi.org/10.1021/acs.jmedchem.1c00374
Autor:
Stanley C, Xie, Riley D, Metcalfe, Hirotake, Mizutani, Tanya, Puhalovich, Eric, Hanssen, Craig J, Morton, Yawei, Du, Con, Dogovski, Shih-Chung, Huang, Jeffrey, Ciavarri, Paul, Hales, Robert J, Griffin, Lawrence H, Cohen, Bei-Ching, Chuang, Sergio, Wittlin, Ioanna, Deni, Tomas, Yeo, Kurt E, Ward, Daniel C, Barry, Boyin, Liu, David L, Gillett, Benigno F, Crespo-Fernandez, Sabine, Ottilie, Nimisha, Mittal, Alisje, Churchyard, Daniel, Ferguson, Anna Caroline C, Aguiar, Rafael V C, Guido, Jake, Baum, Kirsten K, Hanson, Elizabeth A, Winzeler, Francisco-Javier, Gamo, David A, Fidock, Delphine, Baud, Michael W, Parker, Stephen, Brand, Lawrence R, Dick, Michael D W, Griffin, Alexandra E, Gould, Leann, Tilley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Here, we describe inhibitors of the Plasmodium proteasome, an enzymatic complex that malaria parasites rely on to degrade proteins. Starting from inhibitors developed to treat cancer, derivatives were designed and synthesized with the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a17d17dad9983ee3c287198b34e727b8
https://pubmed.ncbi.nlm.nih.gov/34548400
https://pubmed.ncbi.nlm.nih.gov/34548400
Publikováno v:
ARKIVOC, Vol 2003, Iss 8, Pp 188-198 (2003)
Externí odkaz:
https://doaj.org/article/b66e6135095b4fe986730b7eef6301af
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5159f216a3701336ba4dda4e3a9836
https://pubmed.ncbi.nlm.nih.gov/33631934
https://pubmed.ncbi.nlm.nih.gov/33631934
Autor:
Benigno F. Crespo-Fernandez, Eric Hanssen, Elizabeth A. Winzeler, Ioanna Deni, Lawrence Cohen, Du Yawei, Daniel C. Barry, Leann Tilley, Riley D. Metcalfe, David L. Gillett, Kurt E. Ward, Bei-Ching Chuang, Hirotake Mizutani, Lawrence R. Dick, Anna Caroline Campos Aguiar, David A. Fidock, Kirsten K. Hanson, Boyin Liu, Alexandra E. Gould, Stanley C. Xie, Rafael Victorio Carvalho Guido, Francisco-Javier Gamo, Tanya Puhalovich, Shih-Chung Huang, Daniel Ferguson, Paul Hales, Con Dogovski, Sabine Ottilie, Nimisha Mittal, Craig J. Morton, Sergio Wittlin, Robert J. Griffin, Delphine Baud, Tomas Yeo, Michael D. W. Griffin, Jake Baum, Stephen Brand, Alisje Churchyard, Jeffrey Ciavarri, Michael W. Parker
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates that are potent and specific inhibitors of the P. falciparum 20S proteasome (Pf20S) beta5 active site and that exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1732262eee41ce63468baae5797862
Autor:
Xie, Stanley C., Metcalfe, Riley D., Hirotake Mizutani, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Yawei Du, Con Dogovski, Shih-Chung Huang, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Bei-Ching Chuang, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Boyin Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/28/2021, Vol. 118 Issue 39, p1-9, 9p
Autor:
Mi-Sook Kim, Mansoureh Rezaei, Jouhara Chouitar, Katherine Brewer, Michael D. Smith, Alexandra E. Gould, Katherine Galvin, Shih-Chung Huang, Dong Mei Zhang, Sharmila Adhikari, Hirotake Mizutani, Steven P. Langston, Dylan England, Paul D. Greenspan, Emily F. Calderwood, Craig Fisher, Sean J. Harrison, Li-Ting Ma, Saurabh Menon, Roushan Afroze, Jeffery Gaulin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1156-1160
Investigations of a biaryl ether scaffold identified tetrahydronaphthalene Raf inhibitors with good in vivo activity; however these compounds had affinity toward the hERG potassium channel. Herein we describe our work to eliminate this hERG activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6930550d409a9ac05c6295b259baab57
https://doi.org/10.1016/j.bmcl.2016.01.049
https://doi.org/10.1016/j.bmcl.2016.01.049
Autor:
Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap
Publikováno v:
Nature chemical biology. 13(11)
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9174b996cee052b2dfda9c4bae1d2e1a
https://pubmed.ncbi.nlm.nih.gov/28892090
https://pubmed.ncbi.nlm.nih.gov/28892090
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48918d40f47903a78da39dee5fa5f8e
https://doi.org/10.1021/jm101479y
https://doi.org/10.1021/jm101479y
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f238daefd87e22eb7816dddaf60362e3
https://doi.org/10.1038/nature07884
https://doi.org/10.1038/nature07884