Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hirotaka Toh"'
Autor:
Kotaro Tomuro, Mari Mito, Hirotaka Toh, Naohiro Kawamoto, Takahito Miyake, Siu Yu A. Chow, Masao Doi, Yoshiho Ikeuchi, Yuichi Shichino, Shintaro Iwasaki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However, the current method has substantial issues: contamination by r
Externí odkaz:
https://doaj.org/article/3e4840e33a634862b8c9b00c7dcca52c
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109623- (2024)
Summary: Invasive bacterial pathogens are internalized by host cells through endocytosis, which is regulated by a cascade of actin rearrangement signals triggered by host cell receptors or bacterial proteins delivered into host cells. However, the mo
Externí odkaz:
https://doaj.org/article/d0b6e1a3efd947f996eac46b284ca97a
Autor:
Takashi Nozawa, Hirotaka Toh, Junpei Iibushi, Kohei Kogai, Atsuko Minowa-Nozawa, Junko Satoh, Shinji Ito, Kazunori Murase, Ichiro Nakagawa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial infection in xenophagy is not known. Here, we show that t
Externí odkaz:
https://doaj.org/article/1d109d63469449d8962007cdc2c5f3a9
Publikováno v:
Bio-Protocol, Vol 13, Iss 13 (2023)
In vitro translation systems are a useful biochemical tool to research translational regulation. Although the preparation of translation-competent cell extracts from mammals has often been a challenge, the commercially available rabbit reticulocyte l
Externí odkaz:
https://doaj.org/article/f362928f60444998b82549dca7308c52
Autor:
Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to in
Externí odkaz:
https://doaj.org/article/181094b3d4dc4048b7968139d1016659
Autor:
Takashi Nozawa, Junpei Iibushi, Hirotaka Toh, Atsuko Minowa-Nozawa, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Two prominent virulence factors of group A Streptococcus
Externí odkaz:
https://doaj.org/article/a230e164888f408c822ca93ad1d283c7
Autor:
Ching-Yu Lin, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Miyako Hikichi, Junpei Iibushi, Ichiro Nakagawa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Bacterial autophagy—a type of macroautophagy that is also termed xenophagy—selectively targets intracellular bacteria such as group A Streptococcus (GAS), a ubiquitous pathogen that causes numerous serious diseases, including pharyngitis, skin in
Externí odkaz:
https://doaj.org/article/0f7fd3f591fc464593cb41e78161c281
Autor:
Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Group A Streptococcus (GAS) invades epithelial cells causing persistent infection. GAS has a variety of effector proteins that modulate host systems to affect their survival in host environments. The main effector proteins of GAS are NAD-glycohydrola
Externí odkaz:
https://doaj.org/article/9d070aaec9154c15b3a034371ac4c48a
Autor:
Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Group A Streptococcus (GAS) can invade epithelial cells; however, these bacteria are targeted and eventually destroyed by autophagy. Members of the Nod-like receptor (NLR) family are thought to be critical for the autophagic response to invasive bact
Externí odkaz:
https://doaj.org/article/423deb42baf34f31b263c547d12b55ca
Autor:
Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170138 (2017)
Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and
Externí odkaz:
https://doaj.org/article/33a875656e604ff7880968409f42d5e2