Výsledky vyhledávání - "Hirotaka Takama"

Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: design and baseline characteristics of the AYAME study

Autor: Masaomi Nangaku, Hirotaka Takama, Tomohiro Ichikawa, Kazuya Mukai, Masahiro Kojima, Yusuke Suzuki, Hirotaka Watada, Takashi Wada, Kohjiro Ueki, Ichiei Narita, Naoki Kashihara, Takashi Kadowaki, Hiroki Hase, Tadao Akizawa

Publikováno v: Nephrology Dialysis Transplantation. 38:1204-1216

Background Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD), but currently available treatments do not improve kidney function or prevent the initiation of dialysis/kidney replacement therapy. A previous study dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d1255412f3f34a24add3d4660c6594
https://doi.org/10.1093/ndt/gfac242

Zobrazit plný text záznamu

Randomized Clinical Trial on the Effect of Bardoxolone Methyl on GFR in Diabetic Kidney Disease Patients (TSUBAKI Study)

Autor: Masaomi Nangaku, Tadao Akizawa, Hironori Kanda, Hiroki Hase, Hirotaka Takama, Tomohiro Ichikawa

Publikováno v: Kidney International Reports

Introduction Bardoxolone methyl significantly increases estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD). However, the phase 3 study, Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3acf72ae6a4cbe6956ecdb12af42f7
https://doi.org/10.1016/j.ekir.2020.03.030

Zobrazit plný text záznamu

Population pharmacokinetics of darbepoetin alfa in peritoneal dialysis and non-dialysis patients with chronic kidney disease after single subcutaneous administration

Autor: Kazuki Kawakami, Tadao Akizawa, Daisuke Nakashima, Hideji Tanaka, Eiji Uchida, Hirotaka Takama

Publikováno v: European Journal of Clinical Pharmacology. 65:169-178

To characterize the pharmacokinetics of darbepoetin alpha and covariate relationships in chronic kidney disease (CKD) patients after a single subcutaneous administration.A total of 989 serum concentration recordings from 64 patients were analyzed usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c27bb7c904a129a1c09a3e2d737c8be
https://doi.org/10.1007/s00228-008-0561-z

Zobrazit plný text záznamu

Population pharmacokinetics of darbepoetin alfa in haemodialysis and peritoneal dialysis patients after intravenous administration

Autor: Eiji Uchida, Tadao Akizawa, Shozo Koshikawa, Hideji Tanaka, Hirotaka Takama, Hiroyasu Ogata, Daisuke Nakashima

Publikováno v: British Journal of Clinical Pharmacology. 63:300-309

Aims To characterize the pharmacokinetics of darbepoetin alfa and covariate relationships in haemodialysis (HD) and peritoneal dialysis (PD) patients. Methods Data were collected from 131 (63 HD and 68 PD) patients who received darbepoetin alfa intra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e2fd261e324b98135efda32790e215
https://doi.org/10.1111/j.1365-2125.2006.02756.x

Zobrazit plný text záznamu

Pharmacokinetics of pegylated recombinant human megakaryocyte growth and development factor in healthy volunteers and patients with hematological disorders

Autor: Hideji Tanaka, Yasumasa Arai, Yasuo Ikeda, Ryuzo Ohno, Hideaki Mizoguchi, Hirotaka Takama, Junichi Azuma

Publikováno v: European Journal of Haematology. 73:269-279

Objectives: The purpose of this study is to examine the pharmacokinetics of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in healthy volunteers with normal hematopoiesis and patients with idiopathic thrombocyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e08278baf41df1866160fd5de433ec3b
https://doi.org/10.1111/j.1600-0609.2004.00288.x

Zobrazit plný text záznamu

Photoaffinity labeling of peroxisome proliferator binding proteins in rat hepatocytes; dehydroepiandrosterone sulfate- and bezafibrate-binding proteins

Autor: Hirotaka Takama, Takafumi Watanabe, Yoshitoshi Kodama, Hiroyuki Sugiyama, Tetsuya Suga, Junji Yamada, Takeo Taguchi

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1339:321-330

To detect the cellular sites which directly interact with peroxisome proliferators (PPs) and mediate their inducing effect on peroxisomal enzymes in rat hepatocytes, two kinds of radiolabeled ligands, AD12 (7alpha-N-(4-azido-2-hydroxy-5-iodo[125I]ben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dda5f883ca5a4996770c319a46e9387
https://doi.org/10.1016/s0167-4838(97)00016-2

Zobrazit plný text záznamu

The Influence of Formula Concentration on the Absorption of Darbepoetin Alfa after Subcutaneous Administration

Autor: Tadao Akizawa, Tatsuo Yamamoto, Daisuke Nakashima, Kazuki Kawakami, Takayuki Tsuji, Sakuo Hoshi, Tomonori Tayama, Hideji Tanaka, Hirotaka Takama

Publikováno v: Journal of Bioequivalence & Bioavailability.

Darbepoetin alfa (DA) is a hyperglycosylated analog of recombinant human erythropoietin (rHuEPO) that stim u- lates red blood cell production. The aim of this st udy is to investigate the influence of formula concentration on the absorption of DA aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad63d8435c69482d68aac45629796f8e
https://doi.org/10.4172/jbb.1000021

Zobrazit plný text záznamu

Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies

Autor: Yuko Ogasawara, Tsuyoshi Nishitoba, Daisuke Nakashima, Tetsuyoshi Kawakami, Eiji Uchida, Hirotaka Takama, Hideji Tanaka, Sakuo Hoshi

Publikováno v: Journal of clinical pharmacology. 47(10)

Cinacalcet hydrochloride (cinacalcet) is a positive allosteric modulator of the calcium-sensing receptor indicated for the treatment of secondary hyperparathyroidism in dialysis patients. In vitro study has demonstrated that cinacalcet is a potent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88599ffbeb64382807e754015a48d40d
https://pubmed.ncbi.nlm.nih.gov/17652181

Zobrazit plný text záznamu

Pharmacokinetics of pegylated recombinant human megakaryocyte growth and development factor in healthy volunteers and patients with hematological disorders

Autor: Hideji, Tanaka, Hirotaka, Takama, Yasumasa, Arai, Junichi, Azuma, Ryuzo, Ohno, Yasuo, Ikeda, Hideaki, Mizoguchi

Publikováno v: European journal of haematology. 73(4)

The purpose of this study is to examine the pharmacokinetics of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in healthy volunteers with normal hematopoiesis and patients with idiopathic thrombocytopenic purpur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d99fe801f1d49f7dd39c31145bb4941
https://pubmed.ncbi.nlm.nih.gov/15347314

Zobrazit plný text záznamu

Population pharmacokinetic modeling and model validation of a spicamycin derivative, KRN5500, in phase 1 study

Autor: Hirotaka Takama, Tomohide Tamura, Hideji Tanaka, Tomohiro Sudo, Yusuke Tanigawara

Publikováno v: Cancer chemotherapy and pharmacology. 47(5)

Purpose: KRN5500, a novel spicamycin derivative, shows the greatest activity against a human tumor xenograft model and the highest therapeutic index among spicamycin derivatives. KRN5500 is currently under clinical development in Japan and the United

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbcaaff3b906eac996f8a3f456e4d35
https://pubmed.ncbi.nlm.nih.gov/11391855

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání