Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Hirotaka Nakahashi"'
Autor:
Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, Wolfgang Resch, Laura Vian, Marei Dose, Diana Stavreva, Ofir Hakim, Nathanael Pruett, Steevenson Nelson, Arito Yamane, Jason Qian, Wendy Dubois, Scott Welsh, Robert D. Phair, B. Franklin Pugh, Victor Lobanenkov, Gordon L. Hager, Rafael Casellas
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1678-1689 (2013)
The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs). This model, however, is supported by in vitro binding studies of a limited nu
Externí odkaz:
https://doaj.org/article/8d3d3f59f89e43c5926c484dd8f1eb24
Autor:
Arito Yamane, Davide F. Robbiani, Wolfgang Resch, Anne Bothmer, Hirotaka Nakahashi, Thiago Oliveira, Philipp C. Rommel, Eric J. Brown, Andre Nussenzweig, Michel C. Nussenzweig, Rafael Casellas
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 138-147 (2013)
Activation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase. RPA is a single-stranded DNA (ssDNA)-binding protein that associat
Externí odkaz:
https://doaj.org/article/aaf8f984f0064196a3769b21974613df
Autor:
Takashi Ibe, Toshiki Yajima, Hirotaka Nakahashi, Seshiru Nakazawa, Takayuki Kosaka, Ken Shirabe
Publikováno v:
Mediastinum
Taste disorder has been reported as a non-motor symptom caused by myasthenia gravis (MG)-related autoimmune mechanism. Taste disorder in some cases recovered along with MG treatment, such as thymothymectomy or immunosuppressive treatment. However, sy
Autor:
Hirotaka Nakahashi, Yoshitora Kin, Yumeko Miyashiro, Shigeki Kosugi, Katsuhiko Takara, Tomoyuki Izumi, Masamichi Endo
Publikováno v:
Nihon Naika Gakkai Zasshi. 107:1090-1094
Publikováno v:
Rinsho Shinkeigaku. 56:200-203
A 45-year-old man was admitted to our hospital because of taste disorders in March 2014. He exhibited cervical muscle weakness and left eye ptosis, which responded to Tensilon test, and was diagnosed with myasthenia gravis (MG). He developed aspirati
Autor:
Norifumi Tsukamoto, Atsushi Isoda, Shigeki Ito, Akio Saito, Toshihide Kawamura, Hideto Tamura, Kayoko Murayama, Morio Matsumoto, Yutaka Tsukune, Tomomi Miyanaga, Keiichi Moriya, Tohru Sakura, Sakae Tanosaki, Hirokazu Murakami, Hirotaka Nakahashi, Hiroshi Handa, Makoto Sasaki, Akihiko Yokohama, Akihiro Ohtsu, Naoya Nakamura, Masaru Kojima, Michiaki Koike
Publikováno v:
International journal of hematology. 106(5)
Although population-based cancer registries have reported lower incidence of Waldenstrӧm macroglobulinemia (WM) in East Asia than in Western countries, previous retrospective analyses have found the clinical features of WM to be similar in these two
Autor:
Thiago Y. Oliveira, Michel C. Nussenzweig, Philipp C. Rommel, André Nussenzweig, Arito Yamane, Rafael Casellas, Hirotaka Nakahashi, Davide F. Robbiani, Anne Bothmer, Wolfgang Resch, Eric J. Brown
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 138-147 (2013)
SummaryActivation-induced cytidine deaminase (AID) promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in the G1 phase. RPA is a single-stranded DNA (ssDNA)-binding protein that a
Autor:
Junko Hirato, Takeki Mitsui, Hirokazu Murakami, Hideki Uchiumi, Kohtaro Toyama, Norifumi Tsukamoto, Akio Saitoh, Hirotaka Nakahashi, Masaru Kojima, Yoko Hashimoto, Kayoko Murayama, Takahiro Jinbo, Hiromi Koiso, Yoshihisa Nojima, Hiroshi Handa, Morio Matsumoto, Takayuki Saitoh, Morio Sawamura, Masamitsu Karasawa, Akihiko Yokohama
Publikováno v:
Journal of Clinical and Experimental Hematopathology. 53:197-205
We evaluated the prognostic significance of the serum level of the soluble form of interleukin-2 receptorα (sIL-2Rα) and investigated its association with CD25 expression on tumor cells in diffuse large B-cell lymphoma (DLBCL). Three hundred and th
Autor:
Anne Bothmer, Arito Yamane, Rafael Casellas, Thiago Y. Oliveira, Michel C. Nussenzweig, Hirotaka Nakahashi, Mila Jankovic, Isaac A. Klein, Davide F. Robbiani, Camilo Ansarah-Sobrinho, Gordon L. Hager, Genqing Liang, Wolfgang Resch, Ewy Mathé, Ty C. Voss, Kyong-Rim Kieffer-Kwon, Ofir Hakim, Jesse Cobell, André Nussenzweig
Publikováno v:
Nature. 484:69-74
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between translocation partners; however,
Autor:
Akio Saito, Morio Sawamura, Yoshiyuki Ogawa, Hiromi Koiso, Hirokazu Murakami, Takeki Mitsui, Hirotaka Nakahashi, Masamitsu Karasawa, Yoshihisa Nojima, Hiroshi Handa, Kohtaro Toyama, Yohei Osaki, Yoko Hashimoto, Akihiko Yokohama, Norifumi Tsukamoto, Hideki Uchiumi, Takayuki Saitoh
Publikováno v:
European Journal of Haematology. 88:340-349
Objectives: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the production of autoreactive antibodies against platelet antigens. Although dysfunction of multiple aspects of cellular immunity is considered to be important in t