Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hirotaka Kimata"'
Autor:
Hirotaka Kimata, Gaku Ichihara, Yosuke Kato, Mitsunori Iwase, Aya Matsushita, Toyoharu Yokoi, Keiko Hayashi, Kohzo Nagata, Mitsuhiro Yokota, Yasuo Koike, Akiko Noda, Sahoko Ichihara, Katsunori Hashimoto
Publikováno v:
Experimental Animals. 56:339-348
Sepsis is characterized by various symptoms, signs and underlying pathophysiology. To investigate possible mechanisms underlying this diversity, we compared the cardiovascular effects of lipopolysaccharide (LPS) derived from Escherichia coli (E-LPS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feefc8b8094fd1d799d5ae5cbb580398
https://doi.org/10.1538/expanim.56.339
https://doi.org/10.1538/expanim.56.339
Autor:
Hirotaka Kimata, Akiko Noda, Masako Saka, Xian Wu Cheng, Sahoko Ichihara, Hideo Izawa, Kohzo Nagata, Mitsuhiro Yokota, Koji Obata
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 33:1164-1171
SUMMARY 1 Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) manifest pleiotropic effects that may contribute to their therapeutic efficacy. However, the mechanism of the beneficial action of statins on cardiac hypertrophy and fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f7b356c5976eac18a7560897c794e1
https://doi.org/10.1111/j.1440-1681.2006.04508.x
https://doi.org/10.1111/j.1440-1681.2006.04508.x
Autor:
Kohzo Nagata, Takao Nishizawa, Xian Wu Cheng, Toyoaki Murohara, Hirotaka Kimata, Masako Saka, Hideo Izawa, Koji Obata, Mitsuhiro Yokota, Akiko Noda, Sahoko Ichihara
Publikováno v:
Journal of Cardiovascular Pharmacology. 47:770-779
Statin therapy may be associated with lower mortality in patients with heart failure, but the underlying mechanism of such an association is unknown. We have evaluated the effects of pitavastatin on cardiac function and survival in a rat model of hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb6e3e1f948e4ded270aafd55501319
https://doi.org/10.1097/01.fjc.0000211791.22411.0d
https://doi.org/10.1097/01.fjc.0000211791.22411.0d
Autor:
Jun Zhi Xu, Jenson Qi, Kumiko Hikida, Keiko Nakayama, Tetsuhiro Kakimoto, Yoshinori Watanabe, Kiichiro Ueta, Chiaki Kuriyama, Masaharu Shiotani, Kenji Arakawa, Akira Saito, Nobuhiko Taniuchi, Seunghun Paul Lee, Hirotaka Kimata, Yasuaki Matsushita
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 351(2)
Sodium-glucose cotransporter 2 (SGLT2) plays a major role in renal glucose reabsorption. To analyze the potential of insulin-independent blood glucose control, the effects of the novel SGLT2 inhibitor canagliflozin on renal glucose reabsorption and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7007aba57efcaf2d686e740355cd602e
https://pubmed.ncbi.nlm.nih.gov/25216746
https://pubmed.ncbi.nlm.nih.gov/25216746
Autor:
Shigeki Sakamaki, Kiyomi Ohba, Keiko Nakayama, Hirotaka Kimata, Sumihiro Nomura, Yasuo Yamamoto, Chiaki Kuriyama, Yosuke Matsumura, Yasuaki Matsushita, Kiichiro Ueta, Minoru Tsuda-Tsukimoto
Inhibition of the renal sodium glucose cotransporter (SGLT) increases urinary glucose excretion (UGE) and thus reduces blood glucose levels during hyperglycemia. To explore the potential of new antihyperglycemic agents, we synthesized and determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff59bf5c1b66d7ec35a9b487d68391b3
https://europepmc.org/articles/PMC4027614/
https://europepmc.org/articles/PMC4027614/
Publikováno v:
The Journal of endocrinology. 216(1)
Type 2 diabetes is characterized by impaired insulin secretion from pancreatic β-cells. Quantification of the islet area in addition to the insulin-positive area is important for detailed understanding of pancreatic islet histopathology. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce207568d92846fa791cb6f78c658480
https://pubmed.ncbi.nlm.nih.gov/23092878
https://pubmed.ncbi.nlm.nih.gov/23092878
Autor:
Toshiaki Sakamoto, Shigeki Sakamaki, Hirotaka Kimata, Sumihiro Nomura, Yasuo Yamamoto, Yuichi Koga, Minoru Tsuda-Tsukimoto, Mitsuya Hongu, Keiko Nakayama, Kiichiro Ueta, Eiji Kawanishi
Publikováno v:
Journal of medicinal chemistry. 53(17)
We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2 (SGLT2) than the O-glucoside, 2 (T-1095). A novel thiophene derivative 4b-3 (canagliflozin) was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce4697543b1177411ebf4dfde8b1736
https://pubmed.ncbi.nlm.nih.gov/20690635
https://pubmed.ncbi.nlm.nih.gov/20690635
Autor:
Kohzo Nagata, Yasuo Koike, Aya Matsushita, Mitsunori Iwase, Hirotaka Kimata, Akiko Noda, Mitsuhiro Yokota, Keiko Hayashi, Koji Obata, Katsunori Hashimoto, Ayako Fukata
Publikováno v:
Journal of cardiac failure. 14(3)
Background Oxidative stress is implicated in cardiac remodeling and failure. We tested whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and attenuate left ventricular (LV) remodeling and dysfunction in the TO-2 hams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ea686a18e82d85f98fd36c9fa51196
https://pubmed.ncbi.nlm.nih.gov/18381188
https://pubmed.ncbi.nlm.nih.gov/18381188