Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hirotaka Kanoh"'
Autor:
Jin-ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-ichiro Inamori, Koichi Tan-No, Michael Collett
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly fou
Externí odkaz:
https://doaj.org/article/caa20b818c9a4c83b5ef00dcc0053041
Autor:
Jin-ichi Inokuchi, Hirotaka Kanoh
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
GM3 ganglioside, the first molecule in ganglioside family biosynthesis, is formed by transfer of sialic acid to lactosylceramide. Several dozen GM3 molecular species exist, based on diversity of ceramide structures. Among ceramide structures composed
Externí odkaz:
https://doaj.org/article/614c1cbd964e4fd29d178855e78aabc9
Autor:
Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Goto, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe, Aki Hori, Yoshiki Momiuchi, Hiroki Ishikawa, Hiroaki Suzuki, Kumiko Nabe, Takeshi Takagaki, Masataka Fukuzaki, Li-Li Tong, Sinya Yamada, Yoshiteru Oshima, Toshiro Aigaki, Julian A.T. Dow, Shireen-Anne Davies, Shoichiro Kurata
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103473- (2021)
Summary: The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in paralle
Externí odkaz:
https://doaj.org/article/705469bd7383460088a2bdbb5aebbb71
Autor:
Shinzo Iwashita, Hiroaki Suzuki, Akira Goto, Tomohito Oyama, Hirotaka Kanoh, Takayuki Kuraishi, Naoyuki Fuse, Tamaki Yano, Yoshiteru Oshima, Julian A. T. Dow, Shireen-Anne Davies, Shoichiro Kurata
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Innate immunity is an evolutionarily conserved host defense system against infections. The fruit fly Drosophila relies solely on innate immunity for infection defense, and the conservation of innate immunity makes Drosophila an ideal model for unders
Externí odkaz:
https://doaj.org/article/bb1c659510e149dba391012ee372d7f9
NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains
Autor:
Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Hirotaka Kanoh, Kei-ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin-ichi Inokuchi
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 11, Pp 2181-2187 (2018)
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease. Intestinal cholesterol upt
Externí odkaz:
https://doaj.org/article/00cc79c568e2419a8c70020dfe1ebfac
Autor:
Hirotaka Kanoh
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(3)
Chronic inflammation plays an important role in the pathogenesis of obesity and metabolic disorders. In obesity, pattern-recognition receptors in innate immune system, such as Toll-like receptor 4 (TLR4), cause chronic inflammation through prolonged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9252220e93d39879606a66685aa2b301
https://pubmed.ncbi.nlm.nih.gov/35228371
https://pubmed.ncbi.nlm.nih.gov/35228371
Autor:
Kumiko Nabe, Shireen-Anne Davies, Aki Hori, Ryo Watanabe, Akira Goto, Naoyuki Fuse, Shinzo Iwashita, Masataka Fukuzaki, Toshiro Aigaki, Takayuki Kuraishi, Julian A. T. Dow, Shoichiro Kurata, Hiroki Ishikawa, Tomohito Oyama, Yoshiki Momiuchi, Hirotaka Kanoh, Takeshi Takagaki, Li-Li Tong, Sinya Yamada, Mariko Nimura, Haruna Ueno, Hiroaki Suzuki, Chang Tang, Yoshiteru Oshima
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103473-(2021)
iScience
iScience
Summary The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d072b07897bc2f317e404848ccb42
http://www.sciencedirect.com/science/article/pii/S2589004221014449
http://www.sciencedirect.com/science/article/pii/S2589004221014449
Publikováno v:
Biochemical and Biophysical Research Communications. 508:332-337
The Drosophila Toll pathway is involved in embryonic development, innate immunity, and cell-cell interactions. However, compared to the mammalian Toll-like receptor innate immune pathway, its intracellular signaling mechanisms are not fully understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae094abb9bb7f641f1431537a8734a0a
https://doi.org/10.1016/j.bbrc.2018.11.007
https://doi.org/10.1016/j.bbrc.2018.11.007
Autor:
Koichi Fukase, Hirotaka Kanoh, Kei-ichiro Inamori, Jinichi Inokuchi, Takahiro Nitta, Masakazu Nagafuku
Publikováno v:
The FEBS journalReferences. 289(17)
Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex gangliosides. The efforts of our research group since then have been focused on clarifying the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31e279ef0ec43d821d6e45a6b9af9d5
https://pubmed.ncbi.nlm.nih.gov/34125497
https://pubmed.ncbi.nlm.nih.gov/34125497
Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity
Autor:
Umeharu Ohto, Shinji Go, Mika Nagasaki, Kei-ichiro Inamori, Hiromune Ando, Marilena Letizia, Makoto Kiso, Maria Grazia Ciampa, Hideharu Ishida, Kazuya Kabayama, Toshiyuki Shimizu, Jin-ichi Inokuchi, Anna Giulia Cattaneo, Atsushi Shimoyama, Naoko Komura, Sorama Aoki, Hirotaka Kanoh, Mayu Fujii, Hiroki Shindo, Yoshihiro Natori, Taku Watanabe, Yuichi Yoshimura, Koichi Fukase, Wataru Nihei, Akemi Suzuki, Asia Zonca, Lucas Veillon, Laura Mauri, Takahiro Nitta, Yutaka Yatomi, Alessandro Prinetti, Sandro Sonnino, Kenichi Sato
Publikováno v:
The EMBO Journal
Innate immune signaling via TLR4 plays critical roles in pathogenesis of metabolic disorders, but the contribution of different lipid species to metabolic disorders and inflammatory diseases is less clear. GM3 ganglioside in human serum is composed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a0e571142f11ea1baa7418acde7926
https://doi.org/10.15252/embj.2019101732
https://doi.org/10.15252/embj.2019101732