Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hirotada Akiyama"'
Autor:
Hirotada Akiyama, Yoshimasa Iwahana, Mikiya Suda, Atsunori Yoshimura, Hiroyuki Kogai, Ai Nagashima, Hiroko Ohtsuka, Yuko Komiya, Fumio Tashiro
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78716 (2013)
Basal cell adhesion molecule (BCAM), known to be a splicing variant of Lutheran glycoprotein (LU), is an immunoglobulin superfamily membrane protein that acts as a laminin α5 receptor. The high affinity of BCAM/LU for laminin α5 is thought to contr
Externí odkaz:
https://doaj.org/article/2b36323eb02a47a392a8e5862887303b
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56997 (2013)
Oct4 plays a critical role both in maintaining pluripotency and the cell fate decision of embryonic stem (ES) cells. Nonetheless, in the determination of the neuroectoderm (NE) from ES cells, the detailed regulation mechanism of the Oct4 gene express
Externí odkaz:
https://doaj.org/article/1d7d31b5fd4d45a492be245038cba43f
Autor:
Takafumi Uchida, Kengo Furumai, Tomokazu Fukuda, Hirotada Akiyama, Mika Takezawa, Tomoichiro Asano, Fumihiro Fujimori, Chiyoko Uchida
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31823 (2012)
A peptidyl prolyl cis/trans isomerase, Pin1, regulates insulin signal transduction. Pin1 reduces responses to insulin stimulation by binding CRTC2 (CREB-regulated transcriptional co-activator 2) and PPARγ (peroxisome prolifereator- activated recepto
Externí odkaz:
https://doaj.org/article/dd4981bc2c1e42f6b92bc4c272ed73a7
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14656 (2011)
Prolyl isomerase Pin1 may be involved in innate immunity against microbial infection, but the mechanism how Pin1 controls the innate immunity is poorly understood.Injection of lipopolysaccharide (LPS) into the mice induces inflammatory pulmonary diso
Externí odkaz:
https://doaj.org/article/e1834bee78874346b0b6db181c534202
Autor:
Wataru Ninomiya, Tatsuhiro Shibata, Hirotada Akiyama, Fumio Tashiro, Erina Sakamoto, Shigekazu Murakami
Publikováno v:
Stem Cells. 33:2652-2663
The acquisition of stemness is a hallmark of aggressive human hepatocellular carcinoma (hHCC). The stem cell marker OCT4 is frequently expressed in HCCs, and its expression correlates with those of putative cancer stem cell (CSC) markers and CSC prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6323259c671937c8eea56daae17a526
https://doi.org/10.1002/stem.2059
https://doi.org/10.1002/stem.2059
Publikováno v:
Biochemical and Biophysical Research Communications. 444:382-386
The 14-3-3 family of proteins regulates various signaling pathways involved in cell cycle, apoptosis, stress response, and malignant transformation. We previously demonstrated that the β isoform of the 14-3-3 protein promotes cell growth and tumorig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b214b097fd9bf7ac2420f43a954a0796
https://doi.org/10.1016/j.bbrc.2014.01.064
https://doi.org/10.1016/j.bbrc.2014.01.064
Autor:
Isamu Tamura, Akinori Sugiyama, Hirotada Akiyama, Naomi Adachi, Yasushi Kawasaki, Takashi Komeno, Fumio Tashiro, Naoyuki Iida
Publikováno v:
JSM Mycotoxins. 64:117-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea55c4239fe769c6667b5e00db831594
https://doi.org/10.2520/myco.64.117
https://doi.org/10.2520/myco.64.117
Autor:
Hiroyuki Arai, Aina Gotoh, Chiyoko Uchida, Ryong Woon Shin, Takafumi Uchida, Akira Sawa, Akihiro Harada, Tomoe Koga, Hirotada Akiyama, Tsubasa Ohashi, Wataru Sakamoto
Publikováno v:
Journal of Biological Chemistry. 284:32695-32699
Here, we report a novel role for hGas7b (human growth arrest specific protein 7b) in the regulation of microtubules. Using a bioinformatic approach, we studied the actin-binding protein hGas7b with a structural similarity to the WW domain of a peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c637d75afb360400a2419adf35aa989c
https://doi.org/10.1074/jbc.m109.035998
https://doi.org/10.1074/jbc.m109.035998
Autor:
Keiko Hirose, Tomohiko J. Itoh, Chiyoko Uchida, Kangmin Yan, Takafumi Uchida, Wataru Sakamoto, Tomoe Koga, Hirotada Akiyama
Publikováno v:
Journal of Molecular Biology. 391:849-857
The process of microtubule elongation is thought to consist of two stages—formation of a tubulin sheet structure and its closure into a tube. However, real-time observation of this process has been difficult. Here, by utilizing phospho-tau binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743c008fbcd5774ea6e2f7060e65da77
https://doi.org/10.1016/j.jmb.2009.06.081
https://doi.org/10.1016/j.jmb.2009.06.081
Publikováno v:
FEBS Letters. 580:3237-3245
We investigated the enzyme activity of peptidyl prolyl cis/trans isomerases (PPIases) in brain, testis, lung, liver, and mouse embryonic fibroblasts (MEF) of Pin1+/+ and Pin1−/− mice. The aim of this study is to determine if other PPIases can sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a974ffe5d5dd1bcd0861dd298871c3
https://doi.org/10.1016/j.febslet.2006.04.087
https://doi.org/10.1016/j.febslet.2006.04.087