Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

Autor: Hansbro, PM, Kim, RY, Starkey, MR, Donovan, C, Dua, K, Mayall, JR, Liu, G, Hansbro, NG, Simpson, JL, Wood, LG, Hirota, JA, Knight, DA, Foster, PS, Horvat, JC

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Severe, steroid-resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::9b0f24391dec857a2e1efb6f74af6e18
https://hdl.handle.net/10453/125115

Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization

Autor: Gold, MJ, Hiebert, PR, Park, HY, Stefanowicz, D, Le, A, Starkey, MR, Deane, A, Brown, AC, Liu, G, Horvat, JC, Ibrahim, ZA, Sukkar, MB, Hansbro, PM, Carlsten, C, Vaneeden, S, Sin, DD, McNagny, KM, Knight, DA, Hirota, JA

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. PM induces innate immune responses and contributes to allergic sensitization, although the mechanisms governing this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::33d1d53eddc9ba99e8dc01fb997291a9
https://hdl.handle.net/10453/74189

The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm

Autor: Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::a015164e250cc529674af16d8b23fe35
https://hdl.handle.net/10453/146719

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COVID-19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples.

Autor: Nwabufo CK; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.; Program in Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada.; OneDrug Inc., Toronto, ON, Canada., Luc J; Department of Biology and Waterloo Centre for Microbial Research, University of Waterloo, Waterloo, ON, Canada., McGeer A; Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada.; Mount Sinai Hospital, Toronto, Ontario, Canada., Hirota JA; Department of Biology and Waterloo Centre for Microbial Research, University of Waterloo, Waterloo, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Firestone Institute for Respiratory Health-Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.; Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada.; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Mubareka S; Sunnybrook Research Institute, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Doxey AC; Department of Biology and Waterloo Centre for Microbial Research, University of Waterloo, Waterloo, ON, Canada., Moraes TJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.; Program in Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.; Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Sep; Vol. 90 (9), pp. 2137-2158. Date of Electronic Publication: 2024 May 31.