Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Hiroshi Yanagawa"'
Autor:
Mayuko Ide, Noriko Tabata, Yuko Yonemura, Kazuhisa Murai, Ying Wang, Atsuya Ishida, Masao Honda, Shuichi Kaneko, Satoru Ito, Hiroshi Yanagawa
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTOvercoming hepatitis B virus (HBV) is a challenging problem because HBV deceives the host immune system. We have found that DENN domain-containing 2A (DENND2A) was essential for HBV maintenance, although its role remains unclear. In this stud
Externí odkaz:
https://doaj.org/article/8b5dfc1af4224bcba205fcbaf03d835d
Autor:
Ying-Yi Li, Kazuyuki Kuroki, Tetsuro Shimakami, Kazuhisa Murai, Kazunori Kawaguchi, Takayoshi Shirasaki, Kouki Nio, Saiho Sugimoto, Tomoki Nishikawa, Hikari Okada, Noriaki Orita, Hideo Takayama, Ying Wang, Phuong Doan Thi Bich, Astuya Ishida, Sadahiro Iwabuchi, Shinichi Hashimoto, Takeshi Shimaoka, Noriko Tabata, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Hiroshi Yanagawa, Motoharu Seiki, Kouji Matsushima, Taro Yamashita, Shuichi Kaneko, Masao Honda
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 533-558 (2023)
Background & Aims: Hepatitis B virus (HBV) infection is difficult to cure owing to the persistence of covalently closed circular viral DNA (cccDNA). We performed single-cell transcriptome analysis of newly established HBV-positive and HBV-negative he
Externí odkaz:
https://doaj.org/article/5994dbd6cb574256b719639b085d8fe8
Publikováno v:
Journal of Epidemiology, Vol 28, Iss 9, Pp 404-405 (2018)
Externí odkaz:
https://doaj.org/article/f1cfad9826404ec891a955411e16847b
Autor:
Maiko Matsushita, Yoshie Ozaki, Yuka Hasegawa, Fukiko Terada, Noriko Tabata, Hirokazu Shiheido, Hiroshi Yanagawa, Tsukasa Oikawa, Koichi Matsuo, Wenlin Du, Taketo Yamada, Masashi Hozumi, Daiju Ichikawa, Yutaka Hattori
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116135 (2015)
Despite the recent advances in the treatment of multiple myeloma (MM), MM patients with high-risk cytogenetic changes such as t(4;14) translocation or deletion of chromosome 17 still have extremely poor prognoses. With the goal of helping these high-
Externí odkaz:
https://doaj.org/article/09bf3456f4c745db8b4addd92ca12040
NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003841 (2014)
The nuclear export of proteins is regulated largely through the exportin/CRM1 pathway, which involves the specific recognition of leucine-rich nuclear export signals (NESs) in the cargo proteins, and modulates nuclear-cytoplasmic protein shuttling by
Externí odkaz:
https://doaj.org/article/9d64caa95e0e48858e08521cc3905955
Autor:
Takashi Nagata, Kie Shirakawa, Naohiro Kobayashi, Hirokazu Shiheido, Noriko Tabata, Yuko Sakuma-Yonemura, Kenichi Horisawa, Masato Katahira, Nobuhide Doi, Hiroshi Yanagawa
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109163 (2014)
The oncoprotein MDM2 binds to tumor suppressor protein p53 and inhibits its anticancer activity, which leads to promotion of tumor cell growth and tumor survival. Abrogation of the p53:MDM2 interaction reportedly results in reactivation of the p53 pa
Externí odkaz:
https://doaj.org/article/f4bf9967da88400e8b1fcd82e955e48e
Autor:
Taishin Akiyama, Takuma Shiraishi, Junwen Qin, Hiroyasu Konno, Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, Nobukazu Takizawa, Hiromi Yanai, Hiroyuki Ohashi, Etsuko Miyamoto-Sato, Hiroshi Yanagawa, Weidong Yong, Weinian Shou, Jun-Ichiro Inoue
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95992 (2014)
Virus-derived double-stranded RNAs (dsRNAs) are sensed in the cytosol by retinoic acid-inducible gene (RIG)-I-like receptors (RLRs). These induce the expression of type I IFN and proinflammatory cytokines through signaling pathways mediated by the mi
Externí odkaz:
https://doaj.org/article/f1776162c5cc4135bc17b28a1096c26c
Autor:
Mayuko Tokunaga, Hirokazu Shiheido, Noriko Tabata, Yuko Sakuma-Yonemura, Hideaki Takashima, Kenichi Horisawa, Nobuhide Doi, Hiroshi Yanagawa
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76774 (2013)
We recently identified a novel anilinoquinazoline derivative, Q15, as a potent apoptosis inducer in a panel of human cancer cell lines and determined that Q15 targets hCAP-G2, a subunit of condensin II complex, leading to abnormal cell division. Howe
Externí odkaz:
https://doaj.org/article/96eccc392ff24eebad79670f6372d1b2
Autor:
Hirokazu Shiheido, Fukiko Terada, Noriko Tabata, Ichigo Hayakawa, Nobutaka Matsumura, Hideaki Takashima, Yoko Ogawa, Wenlin Du, Taketo Yamada, Mitsuru Shoji, Takeshi Sugai, Nobuhide Doi, Shiro Iijima, Yutaka Hattori, Hiroshi Yanagawa
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38878 (2012)
Despite the introduction of newly developed drugs such as lenalidomide and bortezomib, patients with multiple myeloma are still difficult to treat and have a poor prognosis. In order to find novel drugs that are effective for multiple myeloma, we tes
Externí odkaz:
https://doaj.org/article/39b2b178d8884a0d95e69700689dc38f
Autor:
Nobuhide Doi, Natsuko Yamakawa, Hideaki Matsumoto, Yasutsugu Yamamoto, Tetsuya Nagano, Nobutaka Matsumura, Kenichi Horisawa, Hiroshi Yanagawa
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30084 (2012)
The G protein-coupled receptors (GPCRs), which form the largest group of transmembrane proteins involved in signal transduction, are major targets of currently available drugs. Thus, the search for cognate and surrogate peptide ligands for GPCRs is o
Externí odkaz:
https://doaj.org/article/20365f26da924cec848127af563d1896