Induction of Cell-Cell Connections by Using in situ Laser Lithography on a Perfluoroalkyl-Coated Cultivation Platform

Autor: Mie Matsubara, Yoichiroh Hosokawa, David Yu, Ai Matsui, Atsushi Kira, Ian Liau, Hiroshi Tsubokawa, Hiroshi Masuhara, Kazunori Okano, Yasuyo Maezawa

Publikováno v: ChemBioChem. 12:795-801

This article describes a novel laser-directed microfabrication method carried out in aqueous solution for the organization of cell networks on a platform. A femtosecond (fs) laser was applied to a platform culturing PC12, HeLa, or normal human astroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7380f618c867b312a257bce278bc953
https://doi.org/10.1002/cbic.201000497

Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation

Autor: Heinz Eric Krestel, Stefan Offermanns, Nina Wettschureck, Vincenzo Di Marzo, Alexandra Moers, Mario van der Stelt, Stefania Petrosino, Günther Schütz, Hiroshi Tsubokawa

Publikováno v: Molecular and cellular biology
26 (2006): 5888–5894.
info:cnr-pdr/source/autori:Wettschureck N, van der Stelt M, Tsubokawa H, Krestel H, Moers A, Petrosino S, Schütz G, Di Marzo V, Offermanns S./titolo:Forebrain-specific inactivation of Gq%2FG11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation/doi:/rivista:Molecular and cellular biology (Print)/anno:2006/pagina_da:5888/pagina_a:5894/intervallo_pagine:5888–5894/volume:26
Molecular and Cellular Biology, 26(15), 5888-5894

Metabotropic receptors coupled to Gq/G11 family G proteins critically contribute to nervous system functions by modulating synaptic transmission, often facilitating excitation. We investigated the role of Gq/G11 family G proteins in the regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84367c173775c129dee1c8ced3fde845
https://doi.org/10.1128/mcb.00397-06

Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice

Autor: Norio Sakai, Eri Takahashi, Yasuhito Shirai, Hiroaki Matsubayashi, Masanori Matsuzaki, Hiroshi Tsubokawa, Shiho Ohmori, Yi Ren, Ronald S. Duman, Jingshan Chen, Naoaki Saito, Taketoshi Kajimoto, Haruo Kasai

Publikováno v: Genes to Cells. 9:945-957

To elucidate spatial and temporal profiles of the protein kinase C (PKC) activation in relation to neuronal functions including synaptic plasticity, we tried to detect PKC translocation in living brain slices. We first developed brain region-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60d4d4bc8ee42c648a0a489e6c6a4a4b
https://doi.org/10.1111/j.1365-2443.2004.00779.x

Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus

Autor: Hiroshi Tsubokawa, Yuko Fukudome, Makoto Mark Taketo, Minoru Matsui, Jumpei Shosaku, Takako Ohno-Shosaku, Masanobu Kano, Toshiya Manabe

Publikováno v: European Journal of Neuroscience. 18:109-116

The cholinergic system is crucial for higher brain functions including learning and memory. These functions are mediated primarily by muscarinic acetylcholine receptors (mAChRs) that consist of five subtypes (M(1)-M(5)). A recent study suggested a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1f613c96262c7bc4940d565c0f59e2
https://doi.org/10.1046/j.1460-9568.2003.02732.x

Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses

Autor: Norihide Yoneda, Masanobu Kano, Takako Ohno-Shosaku, Andreas Zimmer, Hiroshi Tsubokawa, Ichiro Mizushima

Publikováno v: The Journal of Neuroscience. 22:3864-3872

金沢大学医薬保健研究域保健学系
Recent studies have clarified that endogenous cannabinoids (endocannabinoids) are released from depolarized postsynaptic neurons in a Ca2+-dependent manner and act retrogradely on presynaptic cannabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385ed7418fa589ccf6cad60147b2776e
https://doi.org/10.1523/jneurosci.22-10-03864.2002