Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Hiroshi Tomoda"'
Autor:
Sergey A. Dyshlovoy, Timofey V. Malyarenko, Olesya I. Zhuravleva, Hiroshi Tomoda, Maxim E. Zhidkov
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 116 (2023)
The term “Far East” implies a huge geographical region that consists of Eastern and Southeastern Asia, Eastern Russia and includes the waters of two oceans—the Pacific and Indian [...]
Externí odkaz:
https://doaj.org/article/51e7dd70efe944518a37d1badc315840
Autor:
Taichi Ohshiro, Keisuke Kobayashi, Mio Ohba, Daisuke Matsuda, Lawrence L. Rudel, Takashi Takahashi, Takayuki Doi, Hiroshi Tomoda
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/S
Externí odkaz:
https://doaj.org/article/ac9b0bfcc18c4273ac51f31d3d43296a
Autor:
Yaojun Tong, Mei Liu, Yu Zhang, Xueting Liu, Ren Huang, Fuhang Song, Huanqin Dai, Biao Ren, Nuo Sun, Gang Pei, Jiang Bian, Xin-Ming Jia, Guanghua Huang, Xuyu Zhou, Shaojie Li, Buchang Zhang, Takashi Fukuda, Hiroshi Tomoda, Satoshi Ōmura, Richard D. Cannon, Richard Calderone, Lixin Zhang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 1, Iss 3, Pp 158-168 (2016)
Multi-drug resistance of pathogenic microorganisms is becoming a serious threat, particularly to immunocompromised populations. The high mortality of systematic fungal infections necessitates novel antifungal drugs and therapies. Unfortunately, with
Externí odkaz:
https://doaj.org/article/df7f26563eeb45d38d53ce5fed0acdbc
Autor:
Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 606 (2020)
Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder with heterotopic ossification (HO) in soft tissues. The abnormal activation of bone morphogenetic protein (BMP) signaling by a mutant activin receptor-like kinase-2 (ALK2) lead
Externí odkaz:
https://doaj.org/article/f9e7be7129464f43aa42b3f4c9b8323a
Autor:
Kanji Hosoda, Nobuhiro Koyama, Hiroshi Hamamoto, Akiho Yagi, Ryuji Uchida, Akihiko Kanamoto, Hiroshi Tomoda
Publikováno v:
Molecules, Vol 25, Iss 21, p 4971 (2020)
Among four mycobacteria, Mycobacterium avium, M. intracellulare, M. bovis BCG and Mycobacteroides (My.) abscessus, we established a silkworm infection assay with My. abscessus. When silkworms (fifth-instar larvae, n = 5) were infected through the hem
Externí odkaz:
https://doaj.org/article/83a2f6e801234efd8da055e12df08238
Publikováno v:
Molecules, Vol 25, Iss 13, p 3079 (2020)
New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various sp
Externí odkaz:
https://doaj.org/article/172289c24ec6437d9cdc4cbf5ef7044b
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 5, Iss 6, Pp 564-568 (2015)
In an analytical study of microbial broths, the actinomycete strain Kitasatospora sp. P07101 was found to produce three new congeners, which were designated hazimycins B (1), C (2), and D (3), together with the previously reported hazimycin (renamed
Externí odkaz:
https://doaj.org/article/d5f177bb40b146d68051542d405db10a
Autor:
Motohiro Sekiya, Daisuke Yamamuro, Taichi Ohshiro, Akira Honda, Manabu Takahashi, Masayoshi Kumagai, Kent Sakai, Shuichi Nagashima, Hiroshi Tomoda, Masaki Igarashi, Hiroaki Okazaki, Hiroaki Yagyu, Jun-ichi Osuga, Shun Ishibashi
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2082-2092 (2014)
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutra
Externí odkaz:
https://doaj.org/article/8b2678c6d9294aa8b1e9b627bef59173
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 2, Pp 141-145 (2014)
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibit
Externí odkaz:
https://doaj.org/article/2945869c097d4713963016f1072d7d67
Publikováno v:
Molecules, Vol 24, Iss 8, p 1495 (2019)
Mycobacterium avium complex (MAC) is a serious disease mainly caused by M. avium and M. intracellulare. Although the incidence of MAC infection is increasing worldwide, only a few agents are clinically used, and their therapeutic effects are limited.
Externí odkaz:
https://doaj.org/article/aadacc16619d4c71aab3e30d89363cdf