Výsledky vyhledávání - "Hiroshi Tanahashi"

Deletion of Lrp4 increases the incidence of microphthalmia

Publikováno v: Biochemical and Biophysical Research Communications. 506:478-484

Microphthalmia is a malformation that reduces the size of the ocular globe. The etiologies of this anomaly are various, but the genetic background appears to have a predominant influence on its development through mutations of genes controlling ocula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81d31ec85934a8f59d2c712a1b6b9a7
https://doi.org/10.1016/j.bbrc.2018.10.062

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RNA interference silencing of DRAL affects processing of amyloid precursor protein

Autor: Hiroshi Tanahashi, Katsuji Yoshioka

Publikováno v: Neuroscience Letters. 439(3):293-297

金沢大学医薬保健研究域医学系
In a previous study, we reported that Alzheimer's disease-associated presenilin-2 interacts with a LIM-domain protein, namely, DRAL/FHL2/SLIM3. In this study, we investigated whether DRAL modifies the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0720eee2b55f4dab826e85e3420f45a5
http://hdl.handle.net/2297/10014

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Association between Tau polymorphism and male early-onset Alzheimer’s disease

Autor: Takeshi Tabira, Takashi Asada, Hiroshi Tanahashi

Publikováno v: NeuroReport. 15:175-179

Neurofibrillary tangles, containing hyperphosphorylated microtubule-associated protein tau, are one of the major pathological hallmarks of Alzheimer's disease. To investigate a possible association between tau genotypes and the risk of Alzheimer's di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504307162a39804f671c360f2d18e79d
https://doi.org/10.1097/00001756-200401190-00034

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Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

Autor: Hiroshi Tanahashi, Takeshi Tabira

Publikováno v: Neuroscience Letters. 307:9-12

Three novel alternatively spliced transcripts of the beta-site amyloid precursor protein cleaving enzyme (BACE) were cloned from human brain. Alternative splicing of the RNA occurs at an internal donor in exon 3 and/or an internal acceptor in exon 4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867bee1b33d2577e44d89c3dc9600a5c
https://doi.org/10.1016/s0304-3940(01)01912-7

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Serial analysis of gene expression in a microglial cell line

Autor: Toru Wakatsuki, Mikio Yamamoto, Akio Suzumura, Haruhisa Inoue, Hiroshi Tanahashi, Takeshi Tabira, Keiko Nakagaki, Akiyuki Hada, Makoto Sawada, Keikichi Takahashi, Nobuo Kondoh, Akihide Ryo

Publikováno v: Glia. 28:265-271

We used the serial analysis of gene expression (SAGE) method to systematically analyze transcripts present in a microglial cell line. Over 10,000 SAGE tags were sequenced, and shown to represent 6,013 unique transcripts. Among the diverse transcripts

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https://doi.org/10.1002/(sici)1098-1136(199912)28:3<265::aid-glia10>3.0.co

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Genome Structure and Chromosomal Mapping of the Gene for Fe65L2 Interacting with Alzheimer's β-Amyloid Precursor Protein

Autor: Hiroshi Tanahashi, Takeshi Tabira

Publikováno v: Biochemical and Biophysical Research Communications. 258:385-389

Recently we cloned the cDNA encoding human Fe65L2, which interacts with Alzheimer's beta-amyloid precursor protein (APP). The protein has one WW domain and two PID elements (Neurosci. Lett. (1999) 261, 143-146.). Here, we report the entire genome str

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https://doi.org/10.1006/bbrc.1999.0639

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Isolation of human delta-catenin and its binding specificity with presenilin 1

Autor: Takeshi Tabira, Hiroshi Tanahashi

Publikováno v: NeuroReport. 10:563-568

We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f836815f1a36ba7978e518ad2c6cca
https://doi.org/10.1097/00001756-199902250-00022

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Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's β-amyloid precursor protein

Autor: Takeshi Tabira, Hiroshi Tanahashi

Publikováno v: Neuroscience Letters. 261:143-146

We report the cDNA sequence of human Fe65L2. The human Fe65L2 encoded 486 amino acids; the deduced amino acid sequence was shorter by 18 amino acids than the rat protein and had 86% identity to the rat protein Three protein-protein interaction domain

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https://doi.org/10.1016/s0304-3940(98)00995-1

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Familial Alzheimer's disease genes in Japanese

Autor: Hideki Yamanaka, Kohei Kamimura, Keikichi Takahashi, Takashi Asada, Hiroshi Tanahashi, Takeshi Tabira

Publikováno v: Journal of the Neurological Sciences. 160:76-81

More than 40 missense mutations and a splice-site mutation in the presenilin 1 (PS-1) gene, two missense mutations of presenilin 2 (PS-2), and more than three missense mutations of amyloid precursor protein (APP) cosegregate with early onset familial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d7fbb642437715b195e1e18b9c5f05
https://doi.org/10.1016/s0022-510x(98)00219-6

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