Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Hiroshi Shirota"'
Autor:
Junji Matsui, Shusei Hamamichi, Ken Ito, Makoto Asano, Hirofumi Fujii, Takanori Abe, Hiroshi Shirota, Izumi O. Umeda, Osamu Asano, Tsuyoshi Akagi, Satoshi Kawano, Akira Yokoi
Publikováno v:
Cancer Science
We previously reported that eribulin mesylate (eribulin), a tubulin‐binding drug (TBD), could remodel tumor vasculature (i.e. increase tumor vessels and perfusion) in human breast cancer xenograft models. However, the role of this vascular remodeli
Autor:
Kou Shimada, Koichiro Sueyoshi, Motohiro Mihara, Shoji Kajikawa, Kazuyuki Yazawa, Hiroshi Shirota
Publikováno v:
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 72:3140-3144
Autor:
Yoko Inoue, Kenzo Muramoto, Naoto Ishii, Yuan John Wang, Kenichi Chiba, Takao Omae, Yoshikazu Kuboi, Masaki Goto, Hiroshi Shirota, Fabian Gusovsky
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:23-31
E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione)] is a novel anti-inflammatory agent that has potent inhibitory effects on the production of proinflammatory cyt
Autor:
Hua Yang, Hiroshi Shirota, W Li, T Sumida, N Masaaki, Yueyun Ding, Marc Lamphier, Fabian Gusovsky, Mark Spyvee, Qian Chen, Mackey Matthew, Isao Matsumoto, K Muramoto, Shawn Schiller, K Ackermann, Y Inoue
Publikováno v:
British Journal of Pharmacology. 160:292-310
Background and purpose: Rheumatoid arthritis (RA) is an autoimmune disorder involving subsets of activated T cells, in particular T helper (Th) 1 and Th17 cells, which infiltrate and damage tissues and induce inflammation. Prostaglandin E2 (PGE2) enh
Autor:
Hiroshi Shirota, Tomotsugu Nakamura, Kuniyuki Gomi, Syoji Kajikawa, Kou Shimada, Kazuyuki Yazawa
Publikováno v:
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 71:57-61
症例は82歳,女性.1年前に上行結腸癌の診断で結腸右半切除術を施行.充実型低分化腺癌のStageIIIaであったため術後補助療法としてテガフール・ウラシルの内服をしていた.術後3カ月目
Autor:
Kuniyuki Gomi, Tomotsugu Nakamura, Kou Shimada, Kazuyuki Yazawa, Shoji Kajikawa, Hiroshi Shirota
Publikováno v:
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 71:828-832
症例は40歳,男性.検診超音波で腹腔内腫瘤を指摘され当院を受診した.腹部CTで肝下面に径10cm大で嚢胞性成分と充実性成分が混在する腫瘤を認め経過観察とした.3カ月後には腹部膨満
Autor:
Isao Tanaka, Fabian Gusovsky, Masanori Fujita, Jesse Chow, Yuan J. Wang, Masaki Goto, Hua Yang, Yoshiharu Mizui, Donna W. Young, Satoshi Yamamoto, Kenichi Chiba, Kenji Tai, Hiroshi Obaishi, Hiroshi Shirota, Kenzo Muramoto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:485-495
The goal of this study is to identify a novel inhibitor with anti-inflammatory and antiproliferative properties for the treatment of psoriasis. Compound f152A1 \[(3 S ,5 Z ,8 S ,11 E )-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1 H -be
Autor:
Hiroshi Shirota, Tomotsugu Nakamura, Kuniyuki Gomi, Kazutaka Nishiyama, Kazuyuki Yazawa, Kou Shimada, Shoji Kajikawa
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 42:1664-1669
症例は55歳の女性で,検診上部消化管内視鏡検査で十二指腸に巨大腫瘍を指摘され当院を受診.腫瘍は十二指腸球部に茎を有し,十二指腸下行脚に伸びる粘膜下腫瘍様の形態であり,超
Autor:
Hirofumi Fujii, Takanori Abe, Shusei Hamamichi, Akira Yokoi, Satoshi Kawano, Makoto Asano, Hiroshi Shirota, Ken Ito, Tsuyoshi Akagi, Osamu Asano, Junji Matsui, Izumi O. Umeda
Publikováno v:
Cancer Research. 77:5927-5927
Eribulin mesilate (Eribulin), a first-in-class halichondrin B-based microtubule dynamics inhibitor, has been reported to remodel tumor vasculature (i.e., improvement of tumor vessels and perfusion) in human breast cancer xenograft models; however, th
Autor:
Roch Boivin, Yongchun Shen, Yuan Wang, Yoshiyuki Kawakami, Yimin Jiang, Hong Du, Hiroshi Shirota, Fabian Gusovsky, Atsushi Inoue, Robert D. Pelletier, Shawn Schiller, Megumi Ikemori-Kawada, Tomohiro Matsushima, Masaki Goto, Naoki Yoneda, Zhiyi Zhang, Charles-André Lemelin, Matthew J. Schnaderbeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3155-3157
Inspired by natural product, LL-Z1640-2, clinical candidate, E6201 (22) was discovered in a medicinal chemistry effort through total synthesis. The modification on C14-position to N-alkyl substitution showed to be potent in vitro and orally active in