Zobrazeno 1 - 10
of 628
pro vyhledávání: '"Hiroshi Shiku"'
Autor:
Masahiro Matsumoto, Shinji Tashiro, Tatsumi Ito, Kazuya Takahashi, Gakuji Hashimoto, Junji Kajihara, Yoshihiro Miyahara, Hiroshi Shiku, Yoichi Katsumoto
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 367-376 (2023)
By analyzing patients treated with adoptive immune cell therapies, various immune cell phenotypes have been found in the starting and infused materials as determinants of sustained remission. The isolation of these specific phenotypes for clinical us
Externí odkaz:
https://doaj.org/article/2519a81bb32f4c479886bbd35c498d85
Autor:
Yuta Takeuchi, Yizheng Wang, Katsunori Sasaki, Osamu Sato, Takahiro Tsuchikawa, Linan Wang, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshifumi Hirokawa, Kanako C. Hatanaka, Yutaka Hatanaka, Takuma Kato, Hiroshi Shiku, Satoshi Hirano
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116052- (2024)
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated impressive success in the treatment of patients with hematologic tumors yet achieved very limited efficacy for solid tumors due to hurdles unique to solid tumors. It is also noted that
Externí odkaz:
https://doaj.org/article/88465710c13d4cf39acdbf42b435c5e8
Publikováno v:
Медицинская иммунология, Vol 25, Iss 2, Pp 271-286 (2023)
According to the common concept of immune editing, the interaction of malignant tumor cells and immune system is a complex multifactorial process, which may result in both antitumor effector activity and development of suppressor mechanisms that prom
Externí odkaz:
https://doaj.org/article/516c8533e48f4a8b89d84866c0deffb6
Autor:
Mikiya Ishihara, Hiroshi Miwa, Hiroshi Fujiwara, Yasushi Akahori, Takuma Kato, Yoshimasa Tanaka, Isao Tawara, Hiroshi Shiku
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107802- (2023)
Summary: Adoptive cell therapy using allogeneic γδ-T cells is a promising option for off-the-shelf T cell products with a low risk of graft-versus-host disease (GVHD). Long-term persistence may boost the clinical development of γδ-T cell products
Externí odkaz:
https://doaj.org/article/3236ef617fcb431ab14dc915f5506fad
Autor:
Alaa Alsalloum, Saleh Alrhmoun, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Julia Lopatnikova, Vasily Kurilin, Marina Volynets, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2805 (2023)
Adoptive T-cell therapies tailored for the treatment of solid tumors encounter intricate challenges, necessitating the meticulous selection of specific target antigens and the engineering of highly specific T-cell receptors (TCRs). This study delves
Externí odkaz:
https://doaj.org/article/5093cd9ee41b46dc9ecc720514ddf6c1
Autor:
Alaa Alsalloum, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Julia Lopatnikova, Kurilin Vasily, Marina Volynets, Evgenii Zavjalov, Olga Solovjeva, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15134 (2023)
TCR-like chimeric antigen receptor (CAR-T) cell therapy has emerged as a game-changing strategy in cancer immunotherapy, offering a broad spectrum of potential antigen targets, particularly in solid tumors containing intracellular antigens. In this s
Externí odkaz:
https://doaj.org/article/0c42bbc455ea408189b9e5de66414018
Autor:
Aleksey S. Bulygin, Julia N. Khantakova, Nadezhda S. Shkaruba, Hiroshi Shiku, Sergey S. Sennikov
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory CD4+ T (Treg) cells play a key role in the induction of immune tolerance and in the prevention of autoimmune diseases. Treg cells are defined by the expression of transcription factor FOXP3, which ensures proliferation and induction of the
Externí odkaz:
https://doaj.org/article/0f6ce8e8526a4ccb92da7f4302914f32
Autor:
Hiroaki Ikeda, Hiroshi Shiku, Shigehisa Kitano, Koji Kato, Shinichi Kageyama, Yoshihiro Miyahara, Mikiya Ishihara, Kazuto Takesako, Takashi Watanabe, Akihiko Matsumine, Makoto Endo, Tomomi Yamada, Satoshi Okumura, Naomi Kiyota, Kimikazu Yakushijin, Kohichi Takada, Shinichiro Kobayashi, Yasuhiro Nagata, Taizo Shiraishi, Keizo Horibe, Hiroshi Miwa
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction Adoptive cell transfer of genetically engineered T cells is a promising treatment for malignancies; however, there are few ideal cancer antigens expressed on the cell surface, and the development of chimeric antigen receptor T cells (CAR
Externí odkaz:
https://doaj.org/article/bb9809a70ebe4968b8c6ed77e521b719
Autor:
Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato, Hiroshi Shiku
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10873 (2023)
The benefits of CAR-T therapy could be expanded to the treatment of solid tumors through the use of derived autologous αβ T cell, but clinical trials of CAR-T therapy for patients with solid tumors have so far been disappointing. CAR-T therapy also
Externí odkaz:
https://doaj.org/article/83648a7a40954f34a11f9a38f3ffd941
Autor:
Takashi Kojima, Hiroaki Ikeda, Sachiko Okamoto, Junichi Mineno, Hiroshi Shiku, Shigehisa Kitano, Shinichi Kageyama, Yoshihiro Miyahara, Mikiya Ishihara, Daisuke Tomura, Ikuei Nukaya, Tetsuro Sasada, Noboru Yamamoto, Takashi Watanabe, Hideyuki Mishima, Alessandra Nardin, Evan Newell, Hidefumi Kato, Hiroyoshi Hattori, Takeru Funakoshi, Eiichi Sato, Hideto Chono, Muhammad Faris Kairi, Phuong Diem Hoang Nguyen, Yannick Simoni, Michael Fehlings
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/abdfa23a1dce47a7a164f412340c65ed