Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiroshi Shikama"'
Autor:
Joerg M. Steiner, Chantal Lainesse, Yuya Noshiro, Yumiko Domen, Heather Sedlacek, Stephen E. Bienhoff, Kelly P. Doucette, David L. Bledsoe, Hiroshi Shikama
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2084-2092 (2023)
Abstract Background Currently, no specific treatment is available for acute onset pancreatitis (AP), and management relies on symptomatic and supportive standard of care (SOC). Fuzapladib is a novel leukocyte function‐associated antigen type‐1 (L
Externí odkaz:
https://doaj.org/article/0f9b757df84e4172a76e5af609f4adcc
Autor:
Jörg M. Steiner, Chantal Lainesse, Yuya Noshiro, Yumiko Domen, Heather Sedlacek, Stephen E. Bienhoff, Kelly P. Doucette, David L. Bledsoe, Hiroshi Shikama
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1285-1286 (2024)
Externí odkaz:
https://doaj.org/article/3c43c39c710c46d89d018a9b310c163f
Autor:
Koji Higuchi, Kohei Yamada, Tsubasa Kihara, Keisuke Makino, Kenta Sasaki, Takeshi Shindo, Hiroshi Shikama, Hideyuki Sato, Satomi Onoue
Publikováno v:
Molecules, Vol 28, Iss 14, p 5325 (2023)
The aim of the present study was to develop an injectable hydrogel (HG) formulation of fuzapladib sodium (FZP), an animal drug for acute pancreatitis (AP), with the use of polyethyleneoxide (PEO) and polylysine (pLys), a cationic polymer. A mixture o
Externí odkaz:
https://doaj.org/article/483febe869ca424a81771266ef2d7e65
Autor:
Satomi Onoue, Koji Higuchi, Chika Yamane, Ryota Tsukada, Kohei Yamada, Kenta Sasaki, Chikako Yoshida, Hiroshi Shikama, Hideyuki Sato
Publikováno v:
Pharmacy & Pharmacology International Journal. 10:225-228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb247e4ff96e9907ab7264fd35df2761
https://doi.org/10.15406/ppij.2022.10.00391
https://doi.org/10.15406/ppij.2022.10.00391
Autor:
Hideyuki Sato, Chika Yamane, Koji Higuchi, Takeshi Shindo, Hiroshi Shikama, Kohei Yamada, Satomi Onoue
Publikováno v:
Pharmaceutical Development and Technology. 27:565-571
The aim of the present study was to develop and evaluate stabilized injection solutions of fuzapladib sodium hydrate using antioxidants as the stabilizers. To estimate the possible degradation factors and pathways of fuzapladib, forced degradation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df451c36edb9db1c6c11c082d44b081
https://doi.org/10.1080/10837450.2022.2089165
https://doi.org/10.1080/10837450.2022.2089165
Autor:
Kohei Yamada, Yuto Hayashi, Kenta Sasaki, Koji Higuchi, Takeshi Shindo, Hiroshi Shikama, Hideyuki Sato, Satomi Onoue
Publikováno v:
Biopharmaceuticsdrug dispositionREFERENCES. 43(3)
This study aimed to develop an oral nanocrystal solid dispersion (nCSD) of fuzapladib (FZP) with enhanced absorbability for the treatment of acute pancreatitis (AP). The hydration properties of crystalline FZP free acid (crystalline FZP) and FZP sodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e43c42c56e9e238d78ecd90b51fd8d
https://pubmed.ncbi.nlm.nih.gov/35322875
https://pubmed.ncbi.nlm.nih.gov/35322875
Autor:
Shoji Miyajima, Kiyomitsu Nemoto, Masakuni Degawa, Shiori Hara, Ryosuke Saigusa, Masaki Yamada, Hiroshi Shikama, Masashi Sekimoto, Shuichi Yotsuya
Publikováno v:
Journal of Health Science. 55:952-956
Cadmium salts induce severe acute testicular necrosis in rodents. We assessed the expression levels of the genes encoding the follicle-stimulating hormone receptor, luteinizing hormone receptor, testis-specific histone 2B, and transition proteins 1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb4f4b4e8b6f63772c81d04570f6fb6
https://doi.org/10.1248/jhs.55.952
https://doi.org/10.1248/jhs.55.952
Autor:
Tadao Bamba, Masashi Imamura, Kazunori Hata, Jin Makino, Hiroshi Shikama, Yoshihide Fujiyama, Shuichi Yotsuya, Akira Andoh
Publikováno v:
Journal of Gastroenterology and Hepatology. 17:854-860
Background: A novel anti-inflammatory drug, IS-741, blocked the adhesion of inflammatory cells to microvascular endothelial cells both in vivo and in vitro. Transgenic rats expressing human leukocyte antigen (HLA)-B27 and human β2-microglobulin (HLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a5a6c07e1a408b2db310f1a5640e19
https://doi.org/10.1046/j.1440-1746.2002.02815.x
https://doi.org/10.1046/j.1440-1746.2002.02815.x
Publikováno v:
Japanese Journal of Pharmacology. 87:151-157
We examined the therapeutic effects of the inflammatory cell infiltration inhibitor IS-741 (N-(2-((ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-cyclohexanecarboxamide monosodium salt monohydrate) on a rat colitis model. As a result of its ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd6da129352d447a18d8e9a06d8b4d7
https://doi.org/10.1254/jjp.87.151
https://doi.org/10.1254/jjp.87.151
Autor:
Masanari Kato, Hiroshi Takada, Yoshihiko Koga, Hideo Sugi, Hiroshi Shikama, Ichiro Nakano, Kimie Sakai, Shuichi Yotsuya
Publikováno v:
Digestion. 60:34-39
A novel synthetic drug, IS-741, inhibited cell adhesion in vitro and neutrophil in vivo. Thus, IS-741 inhibited the magnification of pancreatic lesion as well as progression to multiple organ failure in acute pancreatitis models. Furthermore, IS-741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052aeee247ccb591a862b0748aed4be5
https://doi.org/10.1159/000051451
https://doi.org/10.1159/000051451