Výsledky vyhledávání - "Hiroshi Sawabe"

Akademický článek

Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Autor: Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Publikováno v: Endocrine Journal, Vol 71, Iss 11, Pp 1055-1067 (2024)

We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear. It has been recently reported that SGLT2

Externí odkaz: https://doaj.org/article/c8547725ada84510b6ac63c3efbd6bcb

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Clinical Utility of Reduced Heart Rate Recovery After Exercise in Elderly Patients With Chronic Heart Failure

Autor: Akiya Sakatani, Mayu Nishio, Hiroshi Sawabe, Yasuji Doi, Toru Hayashi, Koichi Miyazaki, Keiji Hirooka, Kiyoshi Kume, Ken-ichiro Okada, Keiji Okuda

Publikováno v: Journal of Cardiac Failure. 23:S72

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7eaf5de8fc6ebbd40323bf78a50f0b0
https://doi.org/10.1016/j.cardfail.2017.08.364

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Effect of Bezafibrate on Microalbuminuria in Diabetic Patients with Early-stage Nephropathy

Autor: Tomio Hayakawa, Tetsuo Yamada, Hiroshi Sawabe, Masamichi Yamada, Tomoyasu Ishiguro

Publikováno v: The Journal of Japan Atherosclerosis Society. 21:579-583

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f8f6848fd1404a1ac8964a46b8d50b
https://doi.org/10.5551/jat1973.21.8_579

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Kinetics and mechanism of the acid-base equilibrium of mexazolam analogues: A modification of the mechanism proposed previously for mexazolam

Autor: Yukihisa Kurono, Tomoko Ichii, Hans Bundgaard, Tomonari Kuwayama, Hiroshi Tamaki, Hiroshi Sawabe, Tamotsu Yashiro, Ken Ikeda

Publikováno v: International Journal of Pharmaceutics. 80:135-143

Oxazolidine ring-opening and ring-closing (acid-base equilibrium) reactions of 3-methyl-11 b -hydrogen ( 1 ) and −11 b -methyl ( 2 ) analogues of mexazolam ( 3 ) have been studied kinetically in solutions of various pH values and at 25°C. Compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e71e18ee0742bc83a5c06c0a73fbaa
https://doi.org/10.1016/0378-5173(92)90271-3

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The Behavior of 1, 4-Benzodiazepine Drugs in Acidic Media. XV. Contribution of Iminium Structure to the Proton Exchange Reaction of 11b-Methylbenzodiazepinooxazoles

Autor: Tamotsu Yashiro, Yukihisa Kurono, Setsuko Kato, Tomonari Kuwayama, Hiroshi Sawabe, Ken Ikeda

Publikováno v: YAKUGAKU ZASSHI. 110:133-138

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9818fb00e7e82718c4aa17a5e1acc0df
https://doi.org/10.1248/yakushi1947.110.2_133

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The behavior of 1,4-benzodiazepine drugs in acidic media. Part XIV. Kinetics and mechanism of the acid-base equilibrium and the subsequent hydrolysis of 11b-hydrogenbenzodiazepinooxazoles

Autor: Ken Ikeda, Tamotsu Yashiro, Yukihisa Kurono, Tomonari Kuwayama, Hiroshi Sawabe

Publikováno v: Chemical and Pharmaceutical Bulletin. 38:193-196

Oxazolidine ring-opening and ring-closing reactions of 11b-hydrogen(11b-nonsubstituted)benzodiazepinooxazoles (HBDOZ) and the subsequent hydrolysis of the diazepine ring were studied kinetically. The difference in the reactivities of the oxazolidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07092248bbeb35b6fadc4a1252cc0e01
https://doi.org/10.1248/cpb.38.193

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