Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Hiroshi Saga"'
Autor:
Hiroshi Saga, Akira Ohhata, Akio Hayashi, Makoto Katoh, Tatsuo Maeda, Hirotaka Mizuno, Yuka Takada, Yuka Komichi, Hiroto Ota, Naoya Matsumura, Masami Shibaya, Tetsuya Sugiyama, Shinji Nakade, Katsuya Kishikawa
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93230 (2014)
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activate
Externí odkaz:
https://doaj.org/article/11d619e4b67d4898933eff5cfd8ed087
Autor:
Kosuke Tanabe, Masao Komeda, Yosuke Toh, Yasunori Kitamura, Tsuyoshi Misawa, Ken’ichi Tsuchiya, Hiroshi Sagara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The global challenge of on-site detection of highly enriched uranium (HEU), a substance with considerable potential for unauthorized use in nuclear security, is a critical concern. Traditional passive nondestructive assay (NDA) techniques, s
Externí odkaz:
https://doaj.org/article/2939e6eca975431181b20a9af557465d
Publikováno v:
No shinkei geka. Neurological surgery. 48(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c503e521fdda6d51f25803133a9c5ba8
https://pubmed.ncbi.nlm.nih.gov/32938815
https://pubmed.ncbi.nlm.nih.gov/32938815
Autor:
Atsushi Hiramatsu, Hiroto Ota, Makoto Katoh, Shingo Nakatani, Taihei Nishiyama, Masahiro Okada, Hiroshi Saga, Juta Kobayashi, Toshihide Watanabe, Tatsuo Maeda, Naoya Matsumura, Shingo Yamamoto, Akira Imagawa, Katsuya Hisaichi, Hideki Moriguchi, Yuka Komichi, Yuzo Iwaki, Tetsuya Sugiyama, Hirooka Yasuo, Yasuyuki Okabe, Akira Ohhata
Publikováno v:
ACS Med Chem Lett
[Image: see text] Lysophosphatidic acid (LPA) is a bioactive lipid mediator that elicits a number of biological functions, including smooth muscle contraction, cell motility, proliferation, and morphological change. LPA is endogenously produced by au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b8ce9909e82c24ecb0fe1fc19bc741
https://pubmed.ncbi.nlm.nih.gov/32551021
https://pubmed.ncbi.nlm.nih.gov/32551021
Autor:
Yoshikazu Takaoka, Masahiro Ikura, Hiromu Egashira, Masahiko Terakado, Masaki Asada, Naoko Karakawa, Naoki Matsunaga, Shinji Nakade, Yuka Takada, Keisuke Hirai, Koji Shinozaki, Hiroshi Saga, Kazuya Hashimura, Masanori Yamada, Hideyuki Ueda, Yoshihiro Sugiura, Masashi Minami, Hidehiro Suzuki, Motoyuki Tanaka
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1281-1286
Scaffold hopping from the amide group of lead compound ONO-7300243 (1) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA1) antagonist 4. Wash-out experiments using rat isolated urethra showed that compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fbce79430dabdbc96ac714da5cb0c5
https://doi.org/10.1021/acsmedchemlett.7b00383
https://doi.org/10.1021/acsmedchemlett.7b00383
Autor:
Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashi
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108997- (2024)
Summary: The neuromuscular junction (NMJ) forms centrally in myotubes and, as the only synapse between motor neuron and myotube, are indispensable for motor activity. The midmuscle formation of NMJs, including midmuscle-restricted expression of NMJ-r
Externí odkaz:
https://doaj.org/article/7e4575ae1e2b4903b70574cd4d6d1a6a
Autor:
Saori Sasaki, Hiromichi Sakai, Mayu Sato, Fumio Sakane, Ke Liu, Hirotaka Mizuno, Naoko Kunii, Hiroshi Saga
Publikováno v:
Pharmacology. 92:99-107
Ten mammalian diacylglycerol kinase (DGK) isozymes (a-γ) have been identified. Recent studies have revealed that DGK isozymes play pivotal roles in a wide variety of pathophysiological functions. Thus, it is important to be able to easily check DGK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1586ca554fcd73efbea57d663540f87
https://doi.org/10.1159/000351849
https://doi.org/10.1159/000351849
Autor:
Motoyuki Tanaka, Taku Fujimoto, Hiromu Habashita, Shinji Nakade, Hideyuki Ueda, Takuya Seko, Yoshikazu Takaoka, Hiroshi Saga, Hiroshi Kohno, Kazuya Hashimura, Hidehiro Suzuki, Masahiko Terakado
Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA1–6. A high throughput screen against LPA1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-730024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ced8b659779be861f753f05860c5e9
https://europepmc.org/articles/PMC5066152/
https://europepmc.org/articles/PMC5066152/
Autor:
Toshiko Yamashita, Yasunori Watanabe, Yasuhiro Murakami, Hiroshi Saga, Mutsuhiro Fujita, Osamu Shimizu, Satoshi Tohma, Tohru Arayae, Hiroyuki Suzuki, Mikio Kuroki, Makoto Nakatsugawa, Shigemi Hatta, Gaku Tanaka, Kazuyoshi Hasegawa, Takashi Yamada, Shunichi Kikuchi, Yuichi Suzuki, Hitoshi Tanaka, Toshimitsu Komatsu, Takehiro Ogawa, Yasuharu Watanabe
Publikováno v:
PROCEEDINGS OF HYDRAULIC ENGINEERING. 49:427-432
The typhoon No.10 hit the Pacific cost in Hokkaido on August 9 in 2003. The casualties were 10 killed and 3 wounded. The missing person has not been found yet. This typhoon gave the biggest damage by flood to Hokkaido in the last twenty years. In Sar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9abe2cebbb9612e5f3072e139ec37752
https://doi.org/10.2208/prohe.49.427
https://doi.org/10.2208/prohe.49.427
Publikováno v:
Journal of Applied Polymer Science. 90:3020-3025
Highly transparent cellulose hydrogels with physical crosslinkage were prepared from nonaqueous organic cellulose solutions and viscose by coagulating and regenerating cellulose in an aqueous solution containing a water-miscible organic solvent. Nona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab651675beef421932b12d9b5ef00de1
https://doi.org/10.1002/app.13015
https://doi.org/10.1002/app.13015