Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Hiroshi SHITARA"'
Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells
Autor:
Ittetsu Nakajima, Takahiro Tsukimura, Terumi Ono, Tomoko Shiga, Hiroshi Shitara, Tadayasu Togawa, Hitoshi Sakuraba, Yuichiro Miyaoka
Publikováno v:
Cell Transplantation, Vol 32 (2023)
Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modifi
Externí odkaz:
https://doaj.org/article/7b45ec56950045838750cd277a979ba4
Autor:
Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou, Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino, Toyoyuki Takada, Toshihiko Shiroishi, Ryo Kominami, Yoshiaki Kikkawa
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2221 (2022)
An MSM/Ms strain was established using Japanese wild mice, which exhibit resistance to several phenotypes associated with aging, such as obesity, inflammation, and tumorigenesis, compared to common inbred mouse strains. MSM/Ms strain is resistant to
Externí odkaz:
https://doaj.org/article/b75c825ab039479b8e28c8ba546586f6
Autor:
Takuya Ohta, Soichiro Yoshikawa, Yuya Tabakawa, Kayoko Yamaji, Kenji Ishiwata, Hiroshi Shitara, Choji Taya, Masatsugu Oh-hora, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiromichi Yonekawa, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Ticks, blood-sucking arthropods, serve as vectors for transmission of infectious diseases including Lyme borreliosis. After tick infestation, several animal species can develop resistance to subsequent infestations, reducing the risk of transmission.
Externí odkaz:
https://doaj.org/article/45860d87f2fe430db6633e4304d36cc6
Autor:
Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko Miwa, Julian Ik-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, Haruo Okado
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 458-471 (2013)
Accumulating evidence suggests that many brain diseases are associated with defects in neuronal migration, suggesting that this step of neurogenesis is critical for brain organization. However, the molecular mechanisms underlying neuronal migration r
Externí odkaz:
https://doaj.org/article/512e1bdaaa934b039514449c1e39aaa2
Autor:
Yuta Seki, Yuki Miyasaka, Sari Suzuki, Kenta Wada, Shumpei P Yasuda, Kunie Matsuoka, Yasuhiro Ohshiba, Kentaro Endo, Rie Ishii, Hiroshi Shitara, Shin-Ichiro Kitajiri, Naomi Nakagata, Hirohide Takebayashi, Yoshiaki Kikkawa
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183477 (2017)
An unconventional myosin encoded by the myosin VI gene (MYO6) contributes to hearing loss in humans. Homozygous mutations of MYO6 result in nonsyndromic profound congenital hearing loss, DFNB37. Kumamoto shaker/waltzer (ksv) mice harbor spontaneous m
Externí odkaz:
https://doaj.org/article/c1e4ee1bdd074964b8ea025c2bba01e6
Autor:
Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-Ichiro Nagatsuka, Kou-Ichi Jishage, Michinori Kohara
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142145 (2015)
We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers. However, uPA/SCID mice show four disadvantages: the human
Externí odkaz:
https://doaj.org/article/07538a74fc8f46e5923100a7415f9d06
Autor:
Kunie Matsuoka, Hiroshi Shitara, Choji Taya, Kenji Kohno, Yoshiaki Kikkawa, Hiromichi Yonekawa
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60958 (2013)
Basophils and eosinophils play important roles in various host defense mechanisms but also act as harmful effectors in allergic disorders. We generated novel basophil- and eosinophil-depletion mouse models by introducing the human diphtheria toxin (D
Externí odkaz:
https://doaj.org/article/c7ffc28a38a14e35bf70b8ad2366cb8e
Autor:
Telma C Esteves, Olympia E Psathaki, Martin J Pfeiffer, Sebastian T Balbach, Dagmar Zeuschner, Hiroshi Shitara, Hiromichi Yonekawa, Marcin Siatkowski, Georg Fuellen, Michele Boiani
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e36850 (2012)
While reprogramming a foreign nucleus after somatic cell nuclear transfer (SCNT), the enucleated oocyte (ooplasm) must signal that biomass and cellular requirements changed compared to the nucleus donor cell. Using cells expressing nuclear-encoded bu
Externí odkaz:
https://doaj.org/article/1de266845ed8472d9e9f4096f307d6da
Autor:
Kosuke Tanegashima, Shiki Okamoto, Yuki Nakayama, Choji Taya, Hiroshi Shitara, Rie Ishii, Hiromichi Yonekawa, Yasuhiko Minokoshi, Takahiko Hara
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10321 (2010)
BACKGROUND: CXCL14 is a chemoattractant for macrophages and immature dendritic cells. We recently reported that CXCL14-deficient (CXCL14(-/-)) female mice in the mixed background are protected from obesity-induced hyperglycemia and insulin resistance
Externí odkaz:
https://doaj.org/article/05a836ce881e4b3db5ecb24c99208f4a
Autor:
Liqin Cao, Hiroshi Shitara, Michihiko Sugimoto, Jun-Ichi Hayashi, Kuniya Abe, Hiromichi Yonekawa
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000756 (2009)
In mammals, observations of rapid shifts in mitochondrial DNA (mtDNA) variants between generations have led to the creation of the bottleneck theory for the transmission of mtDNA. The bottleneck could be attributed to a marked decline of mtDNA conten
Externí odkaz:
https://doaj.org/article/90c0f44f1d2d4cbabc8776958be3d3fa