Zobrazeno 1 - 10
of 1 595
pro vyhledávání: '"Hiroshi SAKAMOTO"'
Autor:
Katsunori Shigehara, Ryuta Kamekura, Ippei Ikegami, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Kentaro Kodama, Yuichiro Asai, Satsuki Miyajima, Hirotaka Nishikiori, Eiji Uno, Keisuke Yamamoto, Kenichi Takano, Hirofumi Chiba, Hirofumi Ohnishi, Shingo Ichimiya
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The relationships between T follicular helper (Tfh) cells and antigen-specific immunoglobulins (sIgs) in patients with allergic respiratory diseases who are receiving antigen immunotherapy (AIT) have not been fully clarified. Therefore, we started to
Externí odkaz:
https://doaj.org/article/098b832b5e25441fb9ce55d2c13c58f8
Autor:
Yosuke Ochi, Takanori Matsui, Keitaro Inoue, Kohei Monobe, Hiroshi Sakamoto, Shunsuke Aoki, Junichi Taira
Publikováno v:
Molecules, Vol 29, Iss 1, p 198 (2023)
The development of drugs targeting gene products associated with insulin resistance holds the potential to enhance our understanding of type 2 diabetes mellitus (T2DM). The virtual screening, based on a three-dimensional (3D) protein structure, is a
Externí odkaz:
https://doaj.org/article/559f5afb2f944434abdd4f5ddfc7a4b4
Autor:
Kosuke Murayama, Ippei Ikegami, Ryuta Kamekura, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Taiki Sato, Akinori Sato, Katsunori Shigehara, Motohisa Yamamoto, Hiroki Takahashi, Ken-ichi Takano, Shingo Ichimiya
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses at the initial and recall phases. Recent studies have indicated the possible involvement of Tfh cells in the process of chronic inflammation. However, the functio
Externí odkaz:
https://doaj.org/article/c16341b1f9e243ec9606a0141a22a29d
Autor:
Satoshi Rokutanda, Shin-Ichi Yamada, Souichi Yanamoto, Hiroshi Sakamoto, Keisuke Omori, Hiromi Rokutanda, Tomoko Yoshimi, Ayumi Fujishita, Yukiko Morita, Noriaki Yoshida, Masahiro Umeda
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Intraoral vertical ramus osteotomy (IVRO) is used to treat mandibular prognathism and temporomandibular disorders. However, the improvement of temporomandibular disorders after IVRO is considered to be due to the anterior and downward moveme
Externí odkaz:
https://doaj.org/article/bece2fe49c514a4baad539b9cc3e0e3c
Publikováno v:
International Journal of Mycobacteriology, Vol 10, Iss 3, Pp 307-311 (2021)
Background: The emergence of frequent hitters (FHs) remains a challenge in drug discovery. We have previously used in silico structure-based drug screening (SBDS) to identify antimycobacterial candidates. However, excluding FHs has not been integrate
Externí odkaz:
https://doaj.org/article/34d154b2cafc4b50ad0ab048b3452600
Autor:
Junichi Taira, Toshiki Nagano, Mitsuru Kitamura, Miho Yamaguchi, Hiroshi Sakamoto, Shunsuke Aoki
Publikováno v:
International Journal of Mycobacteriology, Vol 9, Iss 1, Pp 12-17 (2020)
Background: Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (mtInhA) is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls, and has been targeted in the development of anti-tuberculosis (TB) d
Externí odkaz:
https://doaj.org/article/97460da1b66842b68b5175fda26fdaa8
Publikováno v:
Algorithms, Vol 15, Iss 7, p 229 (2022)
For the feature selection problem, we propose an efficient privacy-preserving algorithm. Let D, F, and C be data, feature, and class sets, respectively, where the feature value x(Fi) and the class label x(C) are given for each x∈D and Fi∈F. For a
Externí odkaz:
https://doaj.org/article/858676c3f94f497e9c09e1245349b119
Autor:
Junichi Taira, Takashi Ito, Hitomi Nakatani, Tomohiro Umei, Hiroki Baba, Shotaro Kawashima, Taira Maruoka, Hideyuki Komatsu, Hiroshi Sakamoto, Shunsuke Aoki
Publikováno v:
International Journal of Mycobacteriology, Vol 6, Iss 2, Pp 142-148 (2017)
Background: Enzymes responsible for cell wall development in Mycobacterium tuberculosis are considered as potential targets of anti-tuberculosis (TB) agents. Mycobacterial cyclopropane mycolic acid synthase 1 (CmaA1) is essential for mycobacterial su
Externí odkaz:
https://doaj.org/article/09a5cbd7097c4d0281b7c973c3828b95
Autor:
Masakazu Sugishima, Junichi Taira, Tatsuya Sagara, Ryota Nakao, Hideaki Sato, Masato Noguchi, Keiichi Fukuyama, Ken Yamamoto, Takuo Yasunaga, Hiroshi Sakamoto
Publikováno v:
Antioxidants, Vol 9, Iss 8, p 673 (2020)
Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH–cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses
Externí odkaz:
https://doaj.org/article/c3addd8353f943f18e8dedeab21cb554
Autor:
Eiko Sakai, Megumi Shimada-Sugawara, Yu Yamaguchi, Hiroshi Sakamoto, Reiko Fumimoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukuba
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 288-298 (2013)
Abstract.: Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. We recently demonstrated that regu
Externí odkaz:
https://doaj.org/article/e236d81c6871433690c105523f5efb79