Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Hiroshi Qadota"'
Autor:
Yohei Matsunaga, Hiroshi Qadota, Nasab Ghazal, Leila Lesanpezeshki, Till Dorendorf, Jasmine C. Moody, Arnaud Ahier, Courtney J. Matheny, Siva A. Vanapalli, Steven Zuryn, Olga Mayans, Jennifer Q. Kwong, Guy M. Benian
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by an elastic region. Here we show that PK2 is a canonical kinase
Externí odkaz:
https://doaj.org/article/bba44bd80c7247d28d8e36412ab42597
Autor:
Leila Lesanpezeshki, Hiroshi Qadota, Masoud Norouzi Darabad, Karishma Kashyap, Carla M. R. Lacerda, Nathaniel J. Szewczyk, Guy M. Benian, Siva A. Vanapalli
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Background Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular pathways contribut
Externí odkaz:
https://doaj.org/article/e16c713ec8cd4da0a9fc2bd1165c2a34
Autor:
Hiroshi Qadota, Annie McPherson, Rachel Corbitt, Evan Kelton Dackowski, Yohei Matsunaga, Andres F Oberhauser, Guy M Benian
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 7 (2022)
AbstractIntegrin plays a crucial role in the attachment of cells to the extracellular matrix. Integrin recruits many proteins intracellularly, including a 4-protein complex (kindlin, ILK, PINCH, and parvin). Caenorhabditis elegansCaenorhabditis elega
Externí odkaz:
https://doaj.org/article/eea7a71f2491439e8ffcd613729671da
Autor:
Jasmine C. Moody, Hiroshi Qadota, April R. Reedy, C. Denise Okafor, Niveda Shanmugan, Yohei Matsunaga, Courtney J. Christian, Eric A. Ortlund, Guy M. Benian
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesi
Externí odkaz:
https://doaj.org/article/97b17489d39b4b8787aa01fe4c4441f9
Autor:
Daniel Porto, Yohei Matsunaga, Barbara Franke, Rhys M Williams, Hiroshi Qadota, Olga Mayans, Guy M Benian, Hang Lu
Publikováno v:
eLife, Vol 10 (2021)
The force-induced unfolding and refolding of proteins is speculated to be a key mechanism in the sensing and transduction of mechanical signals in the living cell. Yet, little evidence has been gathered for its existence in vivo. Prominently, stretch
Externí odkaz:
https://doaj.org/article/3cbb59f548534da7ac17b2502b6e4447
Autor:
Yohei Matsunaga, Yoko Honda, Shuji Honda, Takashi Iwasaki, Hiroshi Qadota, Guy M. Benian, Tsuyoshi Kawano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Insulin-like peptides INS-7 and INS-35 suppress larval diapause in Caenorhabditis elegans via unknown mechanism. Here, Matsunaga et al.show that the secretory polarity of both peptides changes in diapause, when these peptides are secreted into the in
Externí odkaz:
https://doaj.org/article/899ec1d136314117807790e501810fff
Publikováno v:
bioRxiv
Protein phosphatase 2A (PP2A) functions in a variety of cellular contexts. PP2A can assemble into four different complexes based on the inclusion of different regulatory or targeting subunits. The B’’’ regulatory subunit “striatin” forms th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec96d18641233667446a95575d45a85
https://europepmc.org/articles/PMC10028798/
https://europepmc.org/articles/PMC10028798/
Autor:
John Miller, Taylor Moncrief, Guy M. Benian, Ivana Gaziova, Courtney J. Matheny, Hiroshi Qadota, Andres F. Oberhauser
Publikováno v:
Protein Sci
Proper muscle development and function depend on myosin being properly folded and integrated into the thick filament structure. For this to occur the myosin chaperone UNC-45, or UNC-45B, must be present and able to chaperone myosin. Here we use a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eb522ca3933bdb14d2ca583defd991
https://doi.org/10.1002/pro.4180
https://doi.org/10.1002/pro.4180
GTPases cycle between active GTP bound and inactive GDP bound forms. Exchange of GDP for GTP is catalyzed by guanine nucleotide exchange factors (GEFs). GTPase activating proteins (GAPs) accelerate GTP hydrolysis, to promote the GDP bound form. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf4082f467239a2805735bf75af8df2
https://doi.org/10.1101/2022.07.02.498541
https://doi.org/10.1101/2022.07.02.498541
Autor:
Courtney J. Matheny, Hiroshi Qadota, Marion Kimelman, Aaron O. Bailey, Andres F. Oberhauser, Guy M. Benian
Summary/AbstractAs people live longer, age-related diseases, like sarcopenia, will become a greater public health concern. We use the model organism C. elegans to better understand the molecular mechanisms behind muscle maintenance. Muscle function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::456a23962dbeb69cab8aa8d9bb7a7490
https://doi.org/10.1101/2022.06.04.494828
https://doi.org/10.1101/2022.06.04.494828