Zobrazeno 1 - 10
of 569
pro vyhledávání: '"Hiroshi Ozaki"'
Autor:
Tadayoshi Hashimoto, Yoshiaki Nakamura, Yoshito Komatsu, Satoshi Yuki, Naoki Takahashi, Naohiro Okano, Hidekazu Hirano, Koushiro Ohtsubo, Takashi Ohta, Eiji Oki, Tomohiro Nishina, Hisateru Yasui, Hisato Kawakami, Taito Esaki, Nozomu Machida, Ayako Doi, Shogen Boku, Toshihiro Kudo, Yoshiyuki Yamamoto, Akiyoshi Kanazawa, Tadamichi Denda, Masahiro Goto, Naoko Iida, Hiroshi Ozaki, Taro Shibuki, Mitsuho Imai, Takao Fujisawa, Hideaki Bando, Yoichi Naito, Takayuki Yoshino
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background While advanced gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs), acquired resistance from specific mutations in KIT or PDGFRA frequently occurs. We aimed to assess the utility of
Externí odkaz:
https://doaj.org/article/8d89e02235024fa88d2552871e8438cb
Autor:
Masashi Mukohda, Takanori Yano, Toshiyasu Matsui, Sho Nakamura, Jiro Miyamae, Kensuke Toyama, Ryoji Mitsui, Risuke Mizuno, Hiroshi Ozaki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract One feature of hypertension is a microbial imbalance with increased intestinal permeability. In this study, we examined whether an alteration in the microbiota affects blood pressure and intestinal permeability in spontaneously hypertensive
Externí odkaz:
https://doaj.org/article/83628676c0214c75a494c0d6a7143cf4
Autor:
Hiroshi Ozaki, Takeshi Tokida, Hirofumi Nakamura, Hidemitsu Sakai, Toshihiro Hasegawa, Ko Noguchi
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Atmospheric CO2 concentration ([CO2]) has been substantially increasing. Responses of leaf photosynthesis to elevated [CO2] have been intensively investigated because leaf photosynthesis is one of the most important determinants of crop yield. The re
Externí odkaz:
https://doaj.org/article/f87b5aec3ed247608e0ffbd90b179f4f
Autor:
Hitomi Kimura, Yutaka Yoneya, Shoma Mikawa, Noriyuki Kaji, Hiroki Ito, Yasuaki Tsuchida, Hirotsugu Komatsu, Takahisa Murata, Hiroshi Ozaki, Ryota Uchida, Keigo Nishida, Masatoshi Hori
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 123, Iss , Pp 109773- (2020)
Zinc was discovered to be a novel second messenger in immunoreactive cells. We synthesized a novel free zinc chelator, IPZ-010. Here, we investigated the effects of IPZ-010 in a mouse postoperative ileus model and determined the effects of zinc signa
Externí odkaz:
https://doaj.org/article/0e300c5cce69466994e1a6ad8867fb47
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 379-386 (2018)
Zingiberis processum rhizoma (ZPR) is a major active component of daikenchuto (DKT), which induces anti-inflammatory action by inhibiting macrophage infiltration. However, it is unclear whether ZPR is related to DKT-induced anti-inflammatory action v
Externí odkaz:
https://doaj.org/article/cc0494104917433aa0809ca5c8c43350
Autor:
Daisuke Mori, Nobumasa Watanabe, Osamu Kaminuma, Takahisa Murata, Takachika Hiroi, Hiroshi Ozaki, Masatoshi Hori
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 4, Pp 394-405 (2014)
Abstract.: Intestinal inflammation causes disorder in bowel motility. Th17 cytokines are involved in intestinal inflammation. To understand the role of interleukin (IL)-17 in intestinal motility, we examined effects of IL-17A on contractile activitie
Externí odkaz:
https://doaj.org/article/c324395b558545b38ce7d00c7102f17d
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 3, Pp 374-385 (2014)
Rikkunshito (RKT), a Kampo (Japanese herbal) medicine, is used as a prokinetic for patients with various diseases including functional dyspepsia. RKT promotes delayed gastric emptying via 5-HT3 receptor blockade. Otherwise, RKT increases ghrelin rele
Externí odkaz:
https://doaj.org/article/eb015625ee4c4ad3b8e0c2aeb051d4d9
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 312-317 (2013)
Abstract.: Lung fibroblasts are responsible for collagen secretion during normal tissue repair and the development of fibrosis. Many other prostaglandins have been reported to regulate collagen synthesis in lung fibroblasts, but the role of prostagla
Externí odkaz:
https://doaj.org/article/74485a5d02384d889e9f68bc02e50886
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 2, Pp 197-203 (2011)
Abstract.: Increased intrahepatic resistance causes portal hypertension in cirrhosis. Liver myofibroblasts (MFs) are now regarded as the principle cells involved in sinusoidal blood flow regulation. Many other prostaglandin-receptor agonists have bee
Externí odkaz:
https://doaj.org/article/998a4816b98342b5bd834a1879ae5d23
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 1, Pp 98-104 (2010)
Intestinal subepithelial myofibroblasts (ISMFs) are mesenchymal cells that exist under the epithelium of intestines. Primarily isolated ISMFs from rodents have been applied to experiments. However, due to the size of their intestines, the available c
Externí odkaz:
https://doaj.org/article/346006b635c0454da78864b13ab476f8