Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Hiroshi Omote"'
Autor:
Loc Dinh Hoang, Eriko Aoyama, Miki Hiasa, Hiroshi Omote, Satoshi Kubota, Takuo Kuboki, Masaharu Takigawa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17294 (2023)
S-adenosylmethionine (SAM) is considered to be a useful therapeutic agent for degenerative cartilage diseases, although its mechanism is not clear. We previously found that polyamines stimulate the expression of differentiated phenotype of chondrocyt
Externí odkaz:
https://doaj.org/article/0abc17a9f5804a66ad2f146753de0da1
Autor:
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs, Mikio Tanabe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli an
Externí odkaz:
https://doaj.org/article/9c31b685bee4442382a7b84e7402aa22
Autor:
Nobukazu Shitan, Shota Minami, Masahiko Morita, Minaho Hayashida, Shingo Ito, Kojiro Takanashi, Hiroshi Omote, Yoshinori Moriyama, Akifumi Sugiyama, Alain Goossens, Masataka Moriyasu, Kazufumi Yazaki
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108789 (2014)
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf
Externí odkaz:
https://doaj.org/article/e6039fa0d3e14298b0194bf2db556f5b
Publikováno v:
The Journal of Biochemistry. 168:611-620
Facilitative glucose transporters (GLUTs) play crucial roles in glucose utilization and homeostasis. GLUT12 was initially isolated as a novel GLUT4-like transporter involved in insulin-dependent glucose transport. However, tissue distribution and bio
Publikováno v:
The Journal of Biochemistry. 165:479-486
Vesicular nucleotide transporter (VNUT) plays a key role in purinergic signalling through its ability to transport nucleotides. VNUT belongs to the SLC17 family, which includes vesicular glutamate transporters (VGLUTs) and Type I Na+/phosphate cotran
Autor:
Hiroshi Omote, Tatsuya Kawasaki, Yuma Iwai, Mamiyo Kawakami, Tomohiro Nabekura, Takuya Matsumoto, Yoshinori Moriyama, Narinobu Juge
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:2456-2464
Human MATE1 (multidrug and toxin extrusion 1, hMATE1) is a H+/organic cation (OC) exchanger responsible for the final step of toxic organic cation excretion in the kidney and liver. To investigate the mechanism of transport, we have established an in
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:1
Publikováno v:
Purinergic Signalling. 13:387-404
Vesicular storage of ATP is one of the processes initiating purinergic chemical transmission. Although an active transport mechanism was postulated to be involved in the processes, a transporter(s) responsible for the vesicular storage of ATP remaine
Autor:
Satomi Moriyama, Tomoya Takeuchi, Kazuyuki Furuta, Miki Hiasa, Yuika Harada, Hiroshi Omote, Yoshinori Moriyama, Satoshi Tanaka, Takaaki Miyaji
Publikováno v:
Journal of Biological Chemistry. 292:3909-3918
Mast cells are secretory cells that play an important role in host defense by discharging various intragranular contents, such as histamine and serotonin, upon stimulation of Fc receptors. The granules also contain spermine and spermidine, which can
Autor:
Christoph Parthier, Norimichi Nomura, Yunhon Hotta, Takaaki Miyaji, Kumar Nagarathinam, Tohru Terada, Yoshiko Nakada-Nakura, Milton T. Stubbs, Hiroshi Omote, Mikio Tanabe, So Iwata, Narinobu Juge, Kehong Liu, Frank Jaenecke
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major facilitator superfamily (MFS)