Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Hiroshi Ohkawara"'
Autor:
Hiroshi Ureshino, Yasunori Ueda, Shin Fujisawa, Kensuke Usuki, Hideo Tanaka, Masaya Okada, Shugo Kowata, Kazunori Murai, Asao Hirose, Motohiro Shindo, Takashi Kumagai, Takafumi Nakao, Tomoharu Takeoka, Kazuharu Kamachi, Keisuke Kidoguchi, Satoshi Iyama, Junki Inamura, Tsutomu Kobayashi, Eri Kawata, Hiroshi Ohkawara, Takayuki Ikezoe, Shinya Kimura
Publikováno v:
HemaSphere, Vol 7, p e9072115 (2023)
Externí odkaz:
https://doaj.org/article/5d46986c1a534c98a9f192f73aea65a5
Autor:
Masahiko Fukatsu, Hiroshi Ohkawara, Hiroshi Takahashi, Hirotaka Mori, Mai Yaginuma, Mamiko Endo, Akiko Shichishima-Nakamura, Takahiro Sano, Kayo Harada-Shirado, Satoshi Kimura, Kazuei Ogawa, Yuko Hashimoto, Takayuki Ikezoe
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 2, Pp 1152-1158 (2021)
We here report a 21-year-old male who presented with acute myelomonocytic leukemia (AMML) associated with acquired von Willebrand syndrome (AVWS). To our knowledge, this is the first case of AVWS caused by AMML. In our case, following remission-induc
Externí odkaz:
https://doaj.org/article/3c97175e36194befaab10eef18a0307f
Autor:
Miki Furukawa, Xintao Wang, Hiroshi Ohkawara, Masahiko Fukatsu, Lobna Alkebsi, Hiroshi Takahashi, Kayo Harada-Shirado, Akiko Shichishima-Nakamura, Satoshi Kimura, Kazuei Ogawa, Takayuki Ikezoe
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2128-2143 (2019)
Abstract: Endothelial dysfunction in the early phases of hematopoietic stem cell transplantation (HSCT) contributes to a common pathology between transplant-associated thrombotic microangiopathy (TA-TMA) and graft-versus-host disease (GVHD), which ar
Externí odkaz:
https://doaj.org/article/a183cb9e498f4e01ae146679bf06a9cb
Autor:
Rongqing Li, Na Sun, Xin Chen, Xueqin Li, Jie Zhao, Wanpeng Cheng, Hui Hua, Masahiko Fukatsu, Hirotaka Mori, Hiroshi Takahashi, Hiroshi Ohkawara, Miwa Fukami, Masatoshi Okamoto, Yoichi Hamazaki, Kuiyang Zheng, Jing Yang, Takayuki Ikezoe
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
A substitution mutation of valine to phenylalanine at codon encoding position 617 of the Janus kinase 2 (JAK2) gene (JAK2V617F) has been detected in myeloid cells of some individuals with higher levels of proinflammatory cytokine production such as i
Externí odkaz:
https://doaj.org/article/f2e7910c66fd46ee91f514e64761a9e6
Autor:
Koki Ueda, Kazuhiko Ikeda, Takayuki Ikezoe, Kayo Harada-Shirado, Kazuei Ogawa, Yuko Hashimoto, Takahiro Sano, Hiroshi Ohkawara, Satoshi Kimura, Akiko Shichishima-Nakamura, Yuichi Nakamura, Yayoi Shikama, Tsutomu Mori, Philip J. Mason, Monica Bessler, Soji Morishita, Norio Komatsu, Kotaro Shide, Kazuya Shimoda, Shuhei Koide, Kazumasa Aoyama, Motohiko Oshima, Atsushi Iwama, Yasuchika Takeishi
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1001-1015 (2017)
Abstract: High-mobility group AT-hook 2 (HMGA2) is crucial for the self-renewal of fetal hematopoietic stem cells (HSCs) but is downregulated in adult HSCs via repression by MIRlet-7 and the polycomb-recessive complex 2 (PRC2) including EZH2. The HMG
Externí odkaz:
https://doaj.org/article/7d35bd81e24048ababdc3f54d31b7553
Autor:
Masahiko Fukatsu, Takenobu Murakami, Hiroshi Ohkawara, Shunichi Saito, Kazuhiko Ikeda, Suguru Kadowaki, Itaru Sasaki, Mari Segawa, Tomoko Soeda, Akihiko Hoshi, Hiroshi Takahashi, Akiko Shichishima-Nakamura, Kazuei Ogawa, Yoshihiro Sugiura, Hitoshi Ohto, Yasuchika Takeishi, Takayuki Ikezoe, Yoshikazu Ugawa
Publikováno v:
BMC Neurology, Vol 17, Iss 1, Pp 1-5 (2017)
Abstract Background Chronic graft-versus-host disease (GVHD) appears several months following allogenic hematopoietic stem cell transplantation (HSCT) and is clinically analogous to autoimmune disorder. Polymyositis is a common neuromuscular disorder
Externí odkaz:
https://doaj.org/article/7529de5c32a149b895ff7e736077ae22
Autor:
Xiangmin Wang, Bin Pan, Goichi Honda, Xintao Wang, Yuko Hashimoto, Hiroshi Ohkawara, Kailin Xu, Lingyu Zeng, Takayuki Ikezoe
Publikováno v:
Haematologica, Vol 103, Iss 10 (2018)
We previously found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) exerts cytoprotective and pro-angiogenic functions via G-protein coupled receptor 15 (GPR15). TME5 is comprised of three S-S bonds that divide it into thr
Externí odkaz:
https://doaj.org/article/3eb3092899dd4f5bb3a214ac040a7a57
Autor:
Hiroshi Takahashi, Kazuhiko Ikeda, Kazuei Ogawa, Syunnichi Saito, Alain M Ngoma, Yumiko Mashimo, Koki Ueda, Miki Furukawa, Akiko Shichishima-Nakamura, Hiroshi Ohkawara, Kenneth E Nollet, Hitoshi Ohto, Yasuchika Takeishi
Publikováno v:
Biological Research, Vol 48, Iss 0, Pp 1-8 (2015)
BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use
Externí odkaz:
https://doaj.org/article/7c37fd6056dc4a81b3101afb51943a0e
Autor:
Hiroshi Ohkawara, Toshiyuki Ishibashi, Koichi Sugimoto, Kazuhiko Ikeda, Kazuei Ogawa, Yasuchika Takeishi
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105697 (2014)
Membrane type 1-matrix metalloproteinase (MT1-MMP) functions as a signaling molecule in addition to a proteolytic enzyme. Our hypothesis was that MT1-MMP cooperates with protein kinase B (Akt) in tumor necrosis factor (TNF)-α-induced signaling pathw
Externí odkaz:
https://doaj.org/article/1bf76852391d4b1ba5541f52b4a216e4
Autor:
Koichi Sugimoto, Hiroshi Ohkawara, Yuichi Nakamura, Yoh Takuwa, Toshiyuki Ishibashi, Yasuchika Takeishi
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114429 (2014)
BACKGROUND: Atherosclerosis is understood to be a blood vessel inflammation. High-mobility group box-1 (HMGB-1) plays a key role in the systemic inflammation. Tissue factor (TF) is known to lead to inflammation which promotes thrombus formation. Memb
Externí odkaz:
https://doaj.org/article/3028f5cfe9be4be2af76c66bc0d66320