Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Hiroshi Nishimune"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15–18 months old show motor function decline, which can be restored to the young adult leve
Externí odkaz:
https://doaj.org/article/3231155f04094e0fb3d820c8408f9d08
Autor:
Ritsuko Inoue, Hiroshi Nishimune
Publikováno v:
Cells, Vol 12, Iss 17, p 2142 (2023)
Physiological aging causes a decline of motor function due to impairment of motor cortex function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty. There is increasing evidence suggesting that the changes in motor functio
Externí odkaz:
https://doaj.org/article/53e94c36a6c14f378b4fc17ed8a9cf4b
Autor:
Sudheer K. Tungtur, Heather M. Wilkins, Robert S. Rogers, Yomna Badawi, Jessica M. Sage, Abdulbaki Agbas, Omar Jawdat, Richard J. Barohn, Russell H. Swerdlow, Hiroshi Nishimune
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the A
Externí odkaz:
https://doaj.org/article/38dec4f7c64841b98b4be34960b67c6f
Autor:
Yomna Badawi, Hiroshi Nishimune
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from othe
Externí odkaz:
https://doaj.org/article/e91702c1924d4c3ab442735246544125
Autor:
Kenji Takikawa, Hiroshi Nishimune
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 179 (2022)
Synaptic transmission is essential for controlling motor functions and maintaining brain functions such as walking, breathing, cognition, learning, and memory. Neurotransmitter release is regulated by presynaptic molecules assembled in active zones o
Externí odkaz:
https://doaj.org/article/a7863a128158443a8b44ea9b9937973e
Publikováno v:
BioTechniques, Vol 63, Iss 5, Pp 215-220 (2017)
Analysis of mouse behavior often requires expensive equipment and transfer of the mice to new test environments, which could trigger confounding behavior alterations. Here, we describe a system for tracking mouse behavior in home cages using a low-co
Externí odkaz:
https://doaj.org/article/72d0c24336e9428f84bf8bd558af8b88
Autor:
Alyssa N. Coyne, Ileana Lorenzini, Ching-Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Externí odkaz:
https://doaj.org/article/864d5b20cac14a2c8ea1e98ca71ebe07
Autor:
Robert S. Rogers, Sudheer Tungtur, Tomohiro Tanaka, Lisa L. Nadeau, Yomna Badawi, Hua Wang, Hong-Min Ni, Wen-Xing Ding, Hiroshi Nishimune
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Motor neurons in amyotrophic lateral sclerosis (ALS) patients and animal models show degeneration from the nerve terminal, known as dying-back neuropathy. To investigate the mechanism underlying this neuropathy, we analyzed the neuromuscular junction
Externí odkaz:
https://doaj.org/article/34d7ef7375cc4c57b90ceabed2542660
Publikováno v:
BioTechniques, Vol 33, Iss 5, Pp 1018-1024 (2002)
Neurites and other cell processes encounter localized deposits of signaling factors as they grow. The difficulty in generating patterned artificial substrates has hindered the analysis of these instructive factors in vitro. Here we report a simple me
Externí odkaz:
https://doaj.org/article/722ddcabe19540aba6f0410c55af55bd
Autor:
Hiroshi Nishimune, Tomohiro Numata, Jie Chen, Yudai Aoki, Yonghong Wang, Miranda P Starr, Yasuo Mori, John A Stanford
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38029 (2012)
The P/Q-type voltage-dependent calcium channels (VDCCs) are essential for synaptic transmission at adult mammalian neuromuscular junctions (NMJs); however, the subsynaptic location of VDCCs relative to active zones in rodent NMJs, and the functional
Externí odkaz:
https://doaj.org/article/bb35bd9a1bbc4875b6e7a7a4b3386800