Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hiroshi NISHIWAKI"'
Autor:
Hiroshi Nishiwaki, Jun Ueyama, Mikako Ito, Tomonari Hamaguchi, Keiichi Takimoto, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract We aimed to identify gut microbial features in Parkinson’s disease (PD) across countries by meta-analyzing our fecal shotgun sequencing dataset of 94 PD patients and 73 controls in Japan with five previously reported datasets from USA, Ger
Externí odkaz:
https://doaj.org/article/dcd4a11c530748f9a4fe08ed7e2c7a9e
Autor:
Yutaro Fuse, Yoshitaka Nagashima, Hiroshi Nishiwaki, Fumiharu Ohka, Yusuke Muramatsu, Yoshio Araki, Yusuke Nishimura, Jumpei Ienaga, Tetsuya Nagatani, Yukio Seki, Kazuhiko Watanabe, Kinji Ohno, Ryuta Saito
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Chronic subdural hematoma (CSDH) often causes neurological deterioration and is treated with hematoma evacuation. This study aimed to assess the feasibility of various machine learning models to preoperatively predict the functional outcome
Externí odkaz:
https://doaj.org/article/8c1145fbaf614d80b6b0ebb5f54641b6
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Parkinson’s disease (PD) is pathologically characterized by the abnormal accumulation of α-synuclein fibrils (Lewy bodies) in the substantia nigra and other brain regions, although the role of Lewy bodies remains elusive. Constipation usu
Externí odkaz:
https://doaj.org/article/94847eab5b644a1786d7270dffe7aaca
Autor:
Hiroshi Nishiwaki, Jun Ueyama, Kenichi Kashihara, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Yoshio Tsuboi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Gut microbiota and fecal bile acids were analyzed in 278 patients with α-synucleinopathies, which were comprised of 28 patients with dementia with Lewy bodies (DLB), 224 patients with Parkinson’s disease (PD), and 26 patients with idiopat
Externí odkaz:
https://doaj.org/article/f75a7a2a06234cfcba4d87855f712657
Autor:
Hiroshi Nishiwaki, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Takumi Yoshida, Hiroyuki Hanada, Ichiro Takeuchi, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract To elucidate the relevance of gut dysbiosis in Parkinson’s disease (PD) in disease progression, we made random forest models to predict the progression of PD in two years by gut microbiota in 165 PD patients. The area under the receiver op
Externí odkaz:
https://doaj.org/article/7912bd23aa984e60bc79b1716143eb60
Autor:
Masaaki Hirayama, Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Jun Ueyama, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Kinji Ohno
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260451 (2021)
The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing d
Externí odkaz:
https://doaj.org/article/a4427b6e874647a68ff3451e2dcb739f
Autor:
Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Tomohiro Ishida, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Jun Ueyama, Teppei Shimamura, Hiroshi Mori, Ken Kurokawa, Masahisa Katsuno, Masaaki Hirayama, Kinji Ohno
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT Gut dysbiosis has been repeatedly reported in Parkinson’s disease (PD) but only once in idiopathic rapid-eye-movement sleep behavior disorder (iRBD) from Germany. Abnormal aggregation of α-synuclein fibrils causing PD possibly starts from
Externí odkaz:
https://doaj.org/article/df6d67fbd5b34d73a8d824ee6265f789
Autor:
Tomoya Hasegawa, Mikako Ito, Satoru Hasegawa, Masaki Teranishi, Koki Takeda, Shuto Negishi, Hiroshi Nishiwaki, Jun-ichi Takeda, Tyler W. LeBaron, Kinji Ohno
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2888 (2022)
Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been rarely reported. In addition, the molecular mechanisms underlying the effects of hydrog
Externí odkaz:
https://doaj.org/article/50dbea2bfa0d4bbbb79c16e90bd1e17f
Autor:
Kai Takahashi, Hiroshi Nishiwaki, Mikako Ito, Kazuhiro Iwaoka, Kenta Takahashi, Yoshio Suzuki, Keita Taguchi, Kanako Yamahara, Yoshio Tsuboi, Kenichi Kashihara, Masaaki Hirayama, Kinji Ohno, Tetsuya Maeda
Publikováno v:
Parkinsonism & Related Disorders. 95:11-17
Parkinson's disease (PD) is associated with gut dysbiosis. However, whether gut dysbiosis can cause motor complications is unclear.Subjects were enrolled from four independent movement disorder centers in Japan. We performed 16S ribosomal RNA gene se
Autor:
Jun Ueyama, Mai Hayashi, Masaaki Hirayama, Hiroshi Nishiwaki, Mikako Ito, Isao Saito, Yoshio Tsuboi, Tomohiko Isobe, Kinji Ohno
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 20; Issue 1; Pages: 213
Animal experiments have indicated that pesticides may affect gut microbiota, which is responsible for the production of short-chain fatty acids (SCFAs) and polyamines. Here, we present a preliminary observation of the relationship between pesticide e