Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hiroshi Kuromi"'
Autor:
Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Nozomi Sakata, Naoko Niimi, Koji Fukui, Minoru Saitoe, Kazunori Sango
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106997- (2023)
Summary: Diabetic peripheral neuropathy (DPN) is the most common chronic, progressive complication of diabetes mellitus. The main symptom is sensory loss; the molecular mechanisms are not fully understood. We found that Drosophila fed a high-sugar di
Externí odkaz:
https://doaj.org/article/32d5bac737654ed5bdb283166b649c36
Autor:
Mari Suzuki, Hiroshi Kuromi, Mayumi Shindo, Nozomi Sakata, Naoko Niimi, Koji Fukui, Minoru Saitoe, Kazunori Sango
SUMMARYDiabetic peripheral neuropathy (DPN) is the most common chronic, progressive complication of diabetes mellitus. The main symptom is sensory loss; the molecular mechanisms are not fully understood. We found that Drosophila fed a high-sugar diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a879482535d388e2da36818be91276d3
https://doi.org/10.1101/2022.09.22.509008
https://doi.org/10.1101/2022.09.22.509008
Autor:
Hiroshi Kuromi
Publikováno v:
YAKUGAKU ZASSHI. 134:851-866
I have studied signal transmission at synapses and the effects of drugs on it at the molecular and cellular levels. Specific areas of research interest are outlined here. 1) Electrophysiological experiments in cats and rabbits suggested that a new ty
Publikováno v:
European Journal of Neuroscience. 32:335-346
Endocytosis at the presynaptic terminal is initiated by Ca(2+) influx through voltage-gated Ca(2+) channels. At the Drosophila neuromuscular junction, we demonstrated two components of endocytosis linked to distinct Ca(2+) channels. A voltage-gated C
Autor:
Matthias Knirr, Hiroshi Kuromi, Amanda W. Wyatt, Christoph M. Schuster, Yoshiaki Kidokoro, Andrea Hellwig, Joern R. Steinert
Publikováno v:
Neuron. 50:723-733
SummaryThe sizes and contents of transmitter-filled vesicles have been shown to vary depending on experimental manipulations resulting in altered quantal sizes. However, whether such a presynaptic regulation of quantal size can be induced under physi
Autor:
Yoshiaki Kidokoro, Hiroshi Kuromi
Publikováno v:
The Neuroscientist. 11:138-147
To maintain synaptic transmission during intense neuronal activities, the synaptic vesicle (SV) pool at release sites is effectively replenished by recruitment of SVs from the reserve pool and/or by endocytosis. The authors have studied dynamics of S
Autor:
Akiko Miwa, Tomio Sasaki, Shogo Ishiuchi, Nobuaki Yamada, Hideaki Yokoo, Seiji Ozawa, Yoichi Nakazato, Hiroshi Kuromi, Haruo Okado, Keisuke Tsuzuki
Publikováno v:
Neuroreport. 12:745-748
AMPA type-glutamate receptor channels (AMPARs) assembled without the GluR2 (GluR-B) subunit are characterized by high Ca 2+ permeability, and are expressed abundantly in cerebellar Bergmann glial cells. Here we show that the morphology of cultured Be
Autor:
Hiroshi Kuromi, Yoshiaki Kidokoro
Publikováno v:
Neuron. 27:133-143
At Drosophila neuromuscular junctions, there are two synaptic vesicle pools, namely the exo/endo cycling pool (ECP) and the reserve pool (RP). We studied the recruitment process from RP using a fluorescent dye, FM1-43. During high-frequency nerve sti
Publikováno v:
Neuropharmacology. 38:645-657
We examined the effects of activation of metabotropic glutamate receptors (mGluRs) on glutamatergic synaptic transmission at the neuromuscular junction of newly hatched Drosophila larvae. In nominally Ca(2+)-free solutions puff-application of low con
Autor:
Hiroshi Kuromi, Yoshiaki Kidokoro
Publikováno v:
Neuron. 20:917-925
In a temperature-sensitive Drosophila mutant, shibire, synaptic vesicles are completely depleted in nerve terminals after stimulation at 34 degrees C, but upon returning to 22 degrees C, endocytosis resumes. In this study, synaptic vesicles in the bo