Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Hiroshi Koshiba"'
1
Changes of toxicological characteristics of adriamycin by conjugation with macromolecule
Autor: Chiemi Wakamatsu, Koji Munechika, Hiroshi Koshiba, Hiroyuki Irie, Yoshiyasu Kawabata, Junichi Kashihara, Masakazu Iwai, Masashi Nohara, Nobuaki Ando
Publikováno v: Journal of Toxicologic Pathology. 6:1-16
Toxicity of adriamycin-oxidized dextran (ADM-OXD), a newly developed antineoplastic macromolecule, was compared with that of adriamycin (ADM). ADM-OXD (0.7, 2.0mgADM/kg) and ADM (0.7mg/kg) were administered intravenously to male and female Wistar rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cc1f55f71aa39d9db6471a9e9b10b51
https://doi.org/10.1293/tox.6.1
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4
Effects of recombinant human macrophage colony-stimulating factor on atherosclerotic lesions established in the aorta of high cholesterol-fed rabbits
Autor: Eiji Asakura, Mamoru Koyama, Syun-ichi Abe, Kazuyuki Kimura, Norifumi Nakamura, Kouji Yada, Kazuhide Naito, Takuji Hanamura, Takeshi Yamauchi, Hiroshi Koshiba, Hiroyuki Irie, Hiroshi Shibata, Shuichi Hanada
Publikováno v: Journal of biochemistry. 129(5)
Anti-atherosclerotic effects of human macrophage colony-stimulating factor were investigated using rabbits fed a high cholesterol diet. Rabbits fed a diet containing 2% cholesterol for 59 days developed hyperlipidemia and atheromatous aortic plaques.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8abf256d5a21f2db2cfeb2cf5c25dee
https://pubmed.ncbi.nlm.nih.gov/11328593
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5
Heparin cofactor II inhibits thrombus formation in a rat thrombosis model
Autor: Tsunetaka Nakajima, Hiroshi Koshiba, Kazuo Takechi, Minoru Tsukada, Katsumi Yamanaga, Takashi Yuuki, Norifumi Nakamura
Publikováno v: Thrombosis research. 98(1)
Heparin cofactor II is postulated to be an extravascular thrombin inhibitor that is physiologically stimulated by dermatan sulfate. However, the role of heparin cofactor II has not yet been clearly demonstrated in vivo. In this study, we estimated th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cba4a21f825decdf85ade8a59ca245
https://pubmed.ncbi.nlm.nih.gov/10706937
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9
Functional Monomers and Polymers. 145. Synthetic Application Based on the Tautomerism of Polymer-Bound Purine and Pyrimidine Bases
Autor: Hiroshi Koshiba, Koichi Kondo, Kiichi Takemoto
Publikováno v: Journal of Macromolecular Science: Part A - Chemistry. 24:1303-1314
Polymer-bound alkylthiopurine and -pyrimidine bases were prepared and used as the polymeric reagents for the reactions of nitrile, olefin, and enone formation. The corresponding low molecular weight compounds were also prepared for comparison. Differ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20db2c24ceda93c188056fb101925f3d
https://doi.org/10.1080/00222338708076947
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10
Time course of the spasmolytic effect of cadmium and cadmium uptake in guinea-pig taenia coli
Autor: Hiroshi Koshiba, Tetsuyuki Nasu
Publikováno v: General Pharmacology: The Vascular System. 15:67-70
o 1. 1. The relationship between tension inhibitory action of cadmium and cadmium uptake was investigated in the smooth muscle of taenia coli. 2. 2. Following a treatment with 0.5 mM Cd 2+ for short periods (1, 5 min), the tension to high-K + returne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ba343349787cadc457386b9c11be25
https://doi.org/10.1016/0306-3623(84)90084-3
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