Zobrazeno 1 - 10
of 526
pro vyhledávání: '"Hiroshi Kawamoto"'
Autor:
Yosuke Nagahata, Hiroshi Kawamoto
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Cells forming malignant tumors are distinguished from those forming normal tissues based on several features: accelerated/dysregulated cell division, disruption of physiologic apoptosis, maturation/differentiation arrest, loss of polarity, and invasi
Externí odkaz:
https://doaj.org/article/b242bbc9f58f44d3a409921b001df6a0
Autor:
Alexis Vandenbon, Rin Mizuno, Riyo Konishi, Masaya Onishi, Kyoko Masuda, Yuka Kobayashi, Hiroshi Kawamoto, Ayako Suzuki, Chenfeng He, Yuki Nakamura, Kosuke Kawaguchi, Masakazu Toi, Masahito Shimizu, Yasuhito Tanaka, Yutaka Suzuki, Shinpei Kawaoka
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Spatial transcriptomics reveal how distant cancer affect gene expression and zonation in mouse liver in a manner that differs between biological pathways.
Externí odkaz:
https://doaj.org/article/48608d65ba534a52a3c3a5a77a96a0fd
Autor:
Rin Mizuno, Hiroaki Hojo, Masatomo Takahashi, Soshiro Kashio, Sora Enya, Motonao Nakao, Riyo Konishi, Mayuko Yoda, Ayano Harata, Junzo Hamanishi, Hiroshi Kawamoto, Masaki Mandai, Yutaka Suzuki, Masayuki Miura, Takeshi Bamba, Yoshihiro Izumi, Shinpei Kawaoka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The presence of cancer can induce systemic disruption of the host homeostasis. Here, the authors show that different solid tumours remotely increase hepatic nicotinamide-Nmethyltransferase disrupting the host urea cycle metabolism in the liver.
Externí odkaz:
https://doaj.org/article/f033da34790f4530b76d6f748729332a
Autor:
Koji Terada, Kenta Kondo, Hirohito Ishigaki, Ayaka Nagashima, Hiroki Satooka, Seiji Nagano, Kyoko Masuda, Teruhisa Kawamura, Takako Hirata, Kazumasa Ogasawara, Yasushi Itoh, Hiroshi Kawamoto, Yasutoshi Agata
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 77-86 (2022)
To develop effective adoptive cell transfer therapy using T cell receptor (TCR)-engineered T cells, it is critical to isolate tumor-reactive TCRs that have potent anti-tumor activity. In humans, tumor-infiltrating lymphocytes (TILs) have been reporte
Externí odkaz:
https://doaj.org/article/26e650926bb94137978f4db5a627454b
Autor:
Yutaka Fukaya, Toshimi Kimura, Yukihiro Hamada, Kenichi Yoshimura, Hiroaki Hiraga, Yuki Yuza, Atsushi Ogawa, Junichi Hara, Katsuyoshi Koh, Atsushi Kikuta, Yuhki Koga, Hiroshi Kawamoto
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionGlucarpidase (CPG2) reduces the lethal toxicity of methotrexate (MTX) by rapid degradation.MethodsIn this study, a CPG2 population pharmacokinetics (popPK) analysis in healthy volunteers (phase 1 study) and a popPK-pharmacodynamics (popPK
Externí odkaz:
https://doaj.org/article/292f626a73b4408999f2f71b86f39e93
Autor:
Junya Kawasoe, Yoichiro Uchida, Hiroshi Kawamoto, Tomoyuki Miyauchi, Takeshi Watanabe, Kenichi Saga, Kosuke Tanaka, Shugo Ueda, Hiroaki Terajima, Kojiro Taura, Etsuro Hatano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Liver ischemia and reperfusion injury (IRI) is one of the obstacles in liver surgery such as liver resection and transplantation. In this study, we investigated the preventive effect on mouse liver IRI by feeding mice with inulin, which is a heteroge
Externí odkaz:
https://doaj.org/article/c3f94e03f44345f1b0dcce5213d4cd37
Autor:
Kyoko Masuda, Hiroshi Kawamoto
Publikováno v:
Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-9 (2021)
Abstract In the regenerative medicine field, allogenic transplantation of regenerated tissues has been promoted because autologous transplantation setting is costly and time-consuming to prepare and therefore unsuitable for emergent treatment. To avo
Externí odkaz:
https://doaj.org/article/aa99cfccd2a64e699dbab051c562a779
Autor:
Takuya Maeda, Seiji Nagano, Soki Kashima, Koji Terada, Yasutoshi Agata, Hiroshi Ichise, Manami Ohtaka, Mahito Nakanishi, Fumihiro Fujiki, Haruo Sugiyama, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 250-260 (2020)
In the current adoptive T cell therapy, T cells from a patient are given back to that patient after ex vivo activation, expansion, or genetic manipulation. However, such strategy depends on the quality of the patient’s T cells, sometimes leading to
Externí odkaz:
https://doaj.org/article/e94f6375e43049b79591e27e60345c7a
Autor:
Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, Shota Komidori, Yoko Shimizu, Harumi Fujita, Li Jiang, Yingyi Kong, Takashi Yamanashi, Jun Seita, Takuya Yamamoto, Shinya Toyokuni, Yoko Hamazaki, Masakazu Hattori, Yasunobu Yoshikai, Peter Boor, Jürgen Floege, Hiroshi Kawamoto, Yasuhiro Murakawa, Nagahiro Minato, Motoko Yanagita
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signali
Externí odkaz:
https://doaj.org/article/4e3ce5bb02bd4250838868a6955a71d3
Autor:
Seiji Nagano, Takuya Maeda, Hiroshi Ichise, Soki Kashima, Manami Ohtaka, Mahito Nakanishi, Toshio Kitawaki, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Kyoko Masuda, Hiroshi Kawamoto
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 126-135 (2020)
Current adoptive T cell therapies conducted in an autologous setting are costly, time-consuming, and depend on the quality of the patient’s T cells, and thus it would be highly beneficial to develop an allogeneic strategy. To this aim, we have deve
Externí odkaz:
https://doaj.org/article/1149dc76f1b64229944bceb0a2222a6e