Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Hiroshi Kawachi"'
Autor:
Izuma Nakayama, Eiji Shinozaki, Hiroshi Kawachi, Takashi Sasaki, Mayu Yunokawa, Junichi Tomomatsu, Takeshi Yuasa, Satoru Kitazono, Kokoro Kobayashi, Keiko Hayakawa, Arisa Ueki, Shunji Takahashi, Kensei Yamaguchi
Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 7932-7940 (2023)
Abstract Background In Japan, microsatellite instability (MSI) testing for solid tumors was introduced in clinical practice in December 2018. Although immune checkpoint inhibitors (ICIs) are established standards of care for patients with MSI‐high
Externí odkaz:
https://doaj.org/article/9b96c2e100c24760ba571998e28d756d
Clinicopathological characteristics of advanced gastric cancer after Helicobacter pylori eradication
Autor:
Junki Tokura, Ken Namikawa, Kaoru Nakano, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Souya Nunobe, Kensei Yamaguchi, Hiroshi Kawachi, Junko Fujisaki
Publikováno v:
JGH Open, Vol 6, Iss 12, Pp 833-838 (2022)
Abstract Background and Aim Helicobacter pylori (H. pylori) eradication has become popular as it prevents the development of gastric cancer. There have been no comprehensive studies on advanced gastric cancer (AGC) after eradication; thus, the clinic
Externí odkaz:
https://doaj.org/article/11c4b4d8b0884646ba6d319fab6ba078
Autor:
Xiaofei Wang, Keika Kaneko, Hiromi Arakawa, Eri Habano, Makiko Omi, Eri Nakashima, Hiroshi Kawachi, Akiko Tonooka, Kohei Omatsu, Hidetaka Nomura, Mayu Yunokawa, Hiroyuki Kanao, Shunji Takahashi, Takeshi Nakajima, Arisa Ueki
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 2, Pp 792-797 (2022)
A 24-year-old woman suspected of Lynch syndrome was found to carry a BRCA1 pathogenic variant, based on germline multigene panel testing (MGPT). The patient was diagnosed with endometrial carcinoma and underwent modified radical hysterectomy, bilater
Externí odkaz:
https://doaj.org/article/4515355e887943b7843016e0cf77c768
Autor:
Manabu Takamatsu, Noriko Yamamoto, Hiroshi Kawachi, Kaoru Nakano, Shoichi Saito, Yosuke Fukunaga, Kengo Takeuchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Risk evaluation of lymph node metastasis (LNM) for endoscopically resected submucosal invasive (T1) colorectal cancers (CRC) is critical for determining therapeutic strategies, but interobserver variability for histologic evaluation remains
Externí odkaz:
https://doaj.org/article/cd57b11def6d49ddab0a2650ff1ccf37
Autor:
Tsuyoshi Nakagawa, Goshi Oda, Hiroshi Kawachi, Toshiaki Ishikawa, Kentaro Okamoto, Hiroyuki Uetake
Publikováno v:
Clinics and Practice, Vol 12, Iss 2, Pp 157-167 (2022)
The activation of signal transducer and activator of transcription 3 (STAT3) has been reported in several types of cancer, where it acts as an oncogene. However, in breast cancer, the clinical role of STAT3 remains unclear. In the present study, the
Externí odkaz:
https://doaj.org/article/2983c444f5044c52af9e2282c6db0921
Autor:
Akiko Tanoue, Kan Katayama, Yugo Ito, Kensuke Joh, Masaaki Toda, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Hiroshi Kawachi, Kunimasa Yan, Masaaki Ito, Esteban C. Gabazza, Karl Tryggvason, Kaoru Dohi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes. Knockdown of crb2 causes glomerular permeability defects in zebrafish, and its complete knockout causes embryonic lethality in mice.
Externí odkaz:
https://doaj.org/article/3d737ece5bb54aff9534bd7cdc927461
Autor:
Ying Zhang, Yoshiyasu Fukusumi, Mutsumi Kayaba, Takashi Nakamura, Ryusuke Sakamoto, Naoki Ashizawa, Hiroshi Kawachi
Publikováno v:
Nefrología, Vol 41, Iss 5, Pp 539-547 (2021)
Background: Topiroxostat, an inhibitor of xanthine oxidoreductase (XOR) was shown to reduce urinary albumin excretion of hyperuricemic patients with chronic kidney disease. However, its pharmacological mechanism is not well understood. In this study,
Externí odkaz:
https://doaj.org/article/52deaa41b5124369b4ede2646ddd0ee5
Autor:
Ken Namikawa, MD, Hiroshi Kawachi, MD, PhD, Yuta Tsugeno, MD, Takeshi Nakajima, MD, PhD, Junko Fujisaki, MD, PhD
Publikováno v:
VideoGIE, Vol 6, Iss 4, Pp 163-166 (2021)
Externí odkaz:
https://doaj.org/article/1e3d9d0a56c24d66b7979d7cf3d8ed7e
Publikováno v:
Case Reports in Gastroenterology, Vol 15, Iss 1, Pp 323-331 (2021)
Gastric mixed adenocarcinoma-neuroendocrine tumor (NET) is a rare composite tumor, and a limited number of studies have reported on it. A 77-year-old man was admitted to our hospital because of acute cholecystitis. He underwent a cholecystectomy. Eso
Externí odkaz:
https://doaj.org/article/8ca09384487e4cf48f13e395b8ce0d05
Autor:
Naoko Honma, Tomio Arai, Yoko Matsuda, Yosuke Fukunaga, Masaaki Muramatsu, Shinobu Ikeda, Yuri Akishima-Fukasawa, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Kengo Takeuchi, Tetuo Mikami
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4502 (2023)
The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unkno
Externí odkaz:
https://doaj.org/article/861097f273b34f3cb54a9bb05823ffd3