Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hiroshi KOHARA"'
Publikováno v:
Journal of Plant Interactions, Vol 13, Iss 1, Pp 442-449 (2018)
Breeding of competitive cultivars has long been fraught with difficulty owing to limited knowledge of the genetic basis of competitive ability. In this study, we examined the diversity of competitive ability in Asian rice and the genetic basis of thi
Externí odkaz:
https://doaj.org/article/902a74ce40504adfb1fed797de88ab33
Autor:
Yuka Yoshinouchi, Yukiko Sorayama, Shiro Kitano, Michiya Matsusaki, Shinji Irie, Yasuyuki Naito, Hiroshi Kohara
Publikováno v:
Acta Biomaterialia. 140:275-288
In vitro Construction of the liver sinusoidal structure using artificial tissue is an important but worthwhile challenge, particularly for assessing the risk of diseases such as sinusoidal obstruction syndrome (SOS). Current models are unsuitable for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71292ebbd3a0141be3942805a90aee4
https://doi.org/10.1016/j.actbio.2021.11.027
https://doi.org/10.1016/j.actbio.2021.11.027
Autor:
Yuta Tanaka, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki
Publikováno v:
Journal of Medicinal Chemistry. 65:4270-4290
Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407ff68d50cb206d4c182ef36b2c1cf
https://doi.org/10.1021/acs.jmedchem.1c02078
https://doi.org/10.1021/acs.jmedchem.1c02078
Autor:
Kosuke Harada, Hideki Furukawa, Hiroshi Kohara, Koki Nishimura, Hisakazu Komori, Yoshiko Okai, Yuta Arai, Yuhei Yamamoto, Katsuhiko Yamamoto, Akio Imanishi, Tadahiro Shinozawa
Publikováno v:
Toxicology in Vitro. 89:105569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d52d2db2b63de828d06b77d8209def57
https://doi.org/10.1016/j.tiv.2023.105569
https://doi.org/10.1016/j.tiv.2023.105569
Autor:
Yoshiyuki Yamaguchi, Makoto Takeda, Ryo Kurita, Takafumi Hiramoto, Hiroyuki Sasaki, Kota Inoue, Akihide Ryo, Yasushi Soda, Shinji Okano, Kenji Ichiyanagi, Atsushi Muraguchi, Hiroshi Kohara, Shohei Miyamoto, Hidehiro Toh, Yasuki Hijikata, Hiroshi Hamana, Hiroyuki Kishi, Maino Tahara, Jiyuan Liao, Kenzaburo Tani, Yoshie Miura, Yoshinao Oda
Publikováno v:
Mol Ther
Recent advances in gene therapy technologies have enabled the treatment of congenital disorders and cancers and facilitated the development of innovative methods, including induced pluripotent stem cell (iPSC) production and genome editing. We recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee13fa73aca157d7e361e7ba39760b1
https://doi.org/10.1016/j.ymthe.2019.09.007
https://doi.org/10.1016/j.ymthe.2019.09.007
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 74
Here, we established a high-throughput in vitro assay system to predict reactive metabolite (RM) formation. First, we performed the glutathione (GSH) consumption assay to monitor GSH levels as an index of RM formation potential using HepaRG cells pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aded16c9009c742e7e5a681ccb76ae6
https://pubmed.ncbi.nlm.nih.gov/33823239
https://pubmed.ncbi.nlm.nih.gov/33823239
Autor:
Hiroshi Kohara, Shiro Kitano, Shinji Irie, Yasuyuki Naito, Yuka Yoshinouchi, Michiya Matsusaki, Yukiko Sorayama
Publikováno v:
SSRN Electronic Journal.
In vitro Construction of the liver sinusoidal structure using artificial tissue is an important but worthwhile challenge, particularly for assessing the risk of diseases such as sinusoidal obstruction syndrome (SOS). Current models are unsuitable for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538f2996e61c162730d28b940e96360e
https://doi.org/10.2139/ssrn.3906842
https://doi.org/10.2139/ssrn.3906842
Publikováno v:
Journal of Plant Interactions, Vol 13, Iss 1, Pp 442-449 (2018)
Breeding of competitive cultivars has long been fraught with difficulty owing to limited knowledge of the genetic basis of competitive ability. In this study, we examined the diversity of competitive ability in Asian rice and the genetic basis of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27b57338e2aed61f47133e90014232f
https://doi.org/10.1080/17429145.2018.1502821
https://doi.org/10.1080/17429145.2018.1502821
Autor:
Hiroyuki Inoue, Megumi Narusawa, Shohei Miyamoto, Chika Sakamoto, Yumiko Matsumura, Kenzaburo Tani, L Hirose-Yotsuya, Atsushi Takahashi, Hiroshi Kohara, Yoshie Ogawa, Kazunari Yamada
Publikováno v:
Cancer Gene Therapy. 24:165-174
Among cancer immunotherapies, granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced tumor cell vaccine (GVAX) therapies appear promising and have been shown to be safe and effective in multiple clinical trials. However, the antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66979d6534e35db4204b4a5e34428d92
https://doi.org/10.1038/cgt.2016.80
https://doi.org/10.1038/cgt.2016.80
Autor:
Kosuke Harada, Hiroshi Kohara, Yoshiko Okai, Matthew Wagoner, Akimitsu Miyawaki, Toshikatsu Matsui, Kazumasa Miyamoto, Kazunori Yamanaka, Piyush Bajaj, Tadahiro Shinozawa
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 173(2)
Cholestasis resulting from hepatic bile acid efflux transporter inhibition may contribute to drug-induced liver injury (DILI). This condition is a common safety-related reason for drug attrition and withdrawal. To screen for safety risks associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d938bd044b68944052e0504984ba02
https://pubmed.ncbi.nlm.nih.gov/31722436
https://pubmed.ncbi.nlm.nih.gov/31722436