Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hiroshi Imoto"'
Autor:
Ikuo Fujimori, Takeshi Wakabayashi, Morio Murakami, Atsutoshi Okabe, Tsuyoshi Ishii, Aaron McGrath, Hua Zou, Kumar Singh Saikatendu, Hiroshi Imoto
Publikováno v:
ACS Omega, Vol 5, Iss 49, Pp 31984-32001 (2020)
Externí odkaz:
https://doaj.org/article/8fe202b89d3b4c45a62afdd13f42dd6b
Autor:
Imamura Keisuke, Tomoaki Hasui, Y. Hiura, Kumar Singh Saikatendu, Ikuo Fujimori, Morio Murakami, Takeshi Wakabayashi, Tsuyoshi Ishii, Hua Zou, J.D. Lawson, S.W. Lane, Y. Kikko, Masaomi Miyamoto, Hiroshi Imoto, A. Nakatani, M. Kasahara, Youichi Kawakita, Takeshi Kato, Makoto Fushimi
Publikováno v:
Journal of Medicinal Chemistry. 62:4915-4935
Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal development and cognition. However, the detailed function of ALK in the central nervous system (CNS)
Autor:
Kumar Singh Saikatendu, Hiroshi Imoto, Ikuo Fujimori, Morio Murakami, Atsutoshi Okabe, Tsuyoshi Ishii, Aaron P. McGrath, Hua Zou, Takeshi Wakabayashi
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 49, Pp 31984-32001 (2020)
ACS Omega, Vol 5, Iss 49, Pp 31984-32001 (2020)
Fragment screening is frequently used for hit identification. However, there was no report starting from a small fragment for the development of an anaplastic lymphoma kinase (ALK) inhibitor, despite the number of ALK inhibitors reported. We began ou
Publikováno v:
Volume 3: Operations, Monitoring, and Maintenance; Materials and Joining.
The present study systematically evaluated base plates and Coarse Grained Heat Affected Zone (CGHAZ) properties of linepipe steels by using the controlled addition of increasing levels of niobium in a low carbon steel for comparison with other alloyi
Autor:
Kentaro Rikimaru, Kenjiro Sato, Hirohisa Miyashita, Toshiki Murata, Tomoyuki Odani, Yoshiyuki Tsujihata, Hiroshi Imoto, Hiromichi Sugimoto, Nobuyuki Negoro, Masahiro Kamaura
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1649-1666
GPR119 has emerged as an attractive target for anti-diabetic agents. We identified a structurally novel GPR119 agonist 22c that carries a 5-(methylsulfonyl)indoline motif as an early lead compound. To generate more potent compounds of this series, st
Publikováno v:
Materia Japan. 58:80-80
Autor:
Yoshiaki Horiguchi, Kenneth A. Bragstad, Clifford D. Mol, Tsuyoshi Maekawa, Junichi Sakamoto, Takeshi Wakabayashi, Nozomi Katayama, Chisako Nomura, Mitsuharu Matsumoto, Hidenori Abe, Kentaro Rikimaru, Miyuki Funami, Takanori Matsuo, Kazutoshi Kawakami, Hiroko Tsuge, Katsuhito Murase, Bi-Ching Sang, Gyorgy Snell, Hiroshi Imoto, Naoto Arimura, Osamu Ujikawa, Toshimasa Tanaka, Douglas R. Dougan, Yu Momose
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:714-733
Herein, we describe the design, synthesis, and structure–activity relationships of novel benzylpyrazole acylsulfonamides as non-thiazolidinedione (TZD), non-carboxylic-acid-based peroxisome proliferator-activated receptor (PPAR) γ agonists. Dockin
Autor:
Toshiro Naruse, Yasuo Kitagawa, Hiroshi Imoto, Hiroaki Kurihara, Mannosuke Saito, Kohtaro Fujie, Shin Toyoda
Publikováno v:
Soil Science and Plant Nutrition. 51:999-1010
Fine- to medium-textured soils are distributed on the Early Pliocene rocks and Pleistocene sandy sediments in the Ka-Etsu plateau. The Jingaoka (JIN) soil was classified into Aluandic Andosols by WRB, and Low-humic Non-allophanic Kuroboku soils by th
Autor:
Shinji Moriyama, Hidekazu Sawada, Yu Momose, Hiroshi Imoto, Hiroyuki Odaka, Junichi Sakamoto, Hiroyuki Kimura
Publikováno v:
European Journal of Pharmacology. 495:17-26
A novel oxyiminoalkanoic acid derivative, TAK-559, (E)-4-[4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl)methoxy]benzyloxyimino]-4-phenylbutyric acid, was synthesized as a candidate of a new type of insulin-sensitizing agent. We report here activation of hum