Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hiroshi IZUTSU"'
Autor:
Masato Mitsuhashi, Katsuya Endo, Kazuhiko Obara, Hiroshi Izutsu, Taishi Ishida, Norio Chikatsu, Atsushi Shinagawa
Publikováno v:
Clinical Medicine Insights: Blood Disorders, Vol 1 (2008)
Apoptosis was induced in heparinized human whole blood by 3 different ways (radiation, bleomycin, or etoposide), and various mRNA were quantified using the method we reported (Clin. Chem. 2006; 52:634-642). We found that cyclin-dependent kinase inhib
Externí odkaz:
https://doaj.org/article/75e15c9a426643eab322e26ed61fadcd
Autor:
Hitoshi, Kameyama, Yoshifumi, Shimada, Hiroshi, Ichikawa, Masayuki, Nagahashi, Jun, Sakata, Takashi, Kobayashi, Hitoshi, Nogami, Satoshi, Maruyama, Yasumasa, Takii, Shujiro, Okuda, Yiwei, Ling, Hiroshi, Izutsu, Keisuke, Kodama, Mitsutaka, Nakada, Toshifumi, Wakai
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 43(11)
Recently, targeted drugs have been developed for the treatment of colorectal cancer(CRC). Among targets, it is well known that KRAS mutations are associated with resistance to epidermal growth factor receptor(EGFR)monoclonal antibodies. However, resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c43856f69edaa0b7a09abc14ac8e634
https://pubmed.ncbi.nlm.nih.gov/27899776
https://pubmed.ncbi.nlm.nih.gov/27899776
Autor:
Hiroyuki Uetake, Toshifumi Wakai, Masayuki Nagahashi, Nobuaki Sato, Julie Y. Tse, Meaghan Russell, Jennifer E. Ring, Hitoshi Kameyama, Yoshifumi Shimada, Alexei Protopopov, Jun Sakata, Takashi Kobayashi, Winslow Powers, Kazuhiro Yoshida, Yiwei Ling, Hiroshi Ichikawa, Shujiro Okuda, Ruobai Sun, Shin-ei Kudo, Stephen Lyle, Joerg Heyer, Keisuke Kodama, Mitsutaka Nakada, Hiroshi Izutsu, Yuko Kitagawa, Eiji Oki, Kazuaki Takabe, Ryoma Yagi
Publikováno v:
Genome Medicine
Background Comprehensive genomic sequencing (CGS) has the potential to revolutionize precision medicine for cancer patients across the globe. However, to date large-scale genomic sequencing of cancer patients has been limited to Western populations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87248678a8e10a3c49ed55f80e07d465
https://doi.org/10.1186/s13073-016-0387-8
https://doi.org/10.1186/s13073-016-0387-8
Autor:
Mitsutaka Nakada, Hiroshi Izutsu, Terumoto Koike, Yoshihiko Maehara, Toshifumi Wakai, Akihiko Kitahara, Masanori Tsuchida, Tatsuya Goto, Seijiro Sato, Tatsuro Okamoto, Kazuki Takada, Keisuke Kodama, Masayuki Nagahashi
Publikováno v:
Journal of Thoracic Oncology. 12:S531-S532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed4043c3888be066845d45ca345b8eb
https://doi.org/10.1016/j.jtho.2016.11.656
https://doi.org/10.1016/j.jtho.2016.11.656
Autor:
Atsushi Shinagawa, Hiroshi Izutsu, Taishi Ishida, Masato Mitsuhashi, Norio Chikatsu, Kazuhiko Obara, Katsuya Endo
Publikováno v:
Clinical Chemistry. 54:673-681
Background: In conventional bioassays, isolated cells are suspended in culture media, incubated in vitro for several days, and then characterized with respect to any cellular changes. In developing new molecular tests under physiological ex vivo cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc13adc5fe14e49d77db01016839e537
https://doi.org/10.1373/clinchem.2007.091975
https://doi.org/10.1373/clinchem.2007.091975
Autor:
Motoko Maemura, Daisuke Tachikawa, Mieko Ogura, Kazuhiko Obara, Hiroshi Izutsu, Katsuya Endo, Stephan R. Targan, Atsushi Shinagawa, Masato Mitsuhashi
Publikováno v:
Pharmaceutical Research
Purpose We introduced a new concept of ex vivo gene expression analysis (Mitsuhashi, Clin Chem 53:148–149, 2007), where drug action was simulated under physiological conditions. This model system was applied to study various fields of drug developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0661aa3c9bd8791d7b911609ac8f65
https://doi.org/10.1007/s11095-007-9510-2
https://doi.org/10.1007/s11095-007-9510-2
Publikováno v:
Journal of Clinical Microbiology. 36:3013-3019
A new technique for the induction of plaque formation by Chlamydia trachomatis biovar trachoma applicable to the titration of infectivity and cloning of biovar trachoma was established. Three novel strains were cloned and confirmed to be free of glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eded37b737e6de3b24fdca1229afa9ac
https://doi.org/10.1128/jcm.36.10.3013-3019.1998
https://doi.org/10.1128/jcm.36.10.3013-3019.1998
Autor:
Akira Matsumoto, Hiroshi Izutsu, Toshiharu Matsushima, Toshihide Morikawa, Toshio Kishimoto, Yoshifumi Kubota, Rinzo Soejima, Kiyotaka Kawagoe
Publikováno v:
Journal of the Japanese Association for Infectious Diseases. 70:821-829
Studies were conducted with the goal of developing a kit for assaying anti-Chlamydia pneumoniae antibodies in human serum which would enable judging positive cases with high specificity by means of an objective numerical index. Thus, an enzyme-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c26d04d049d6ef922d81d42fdc168f
https://doi.org/10.11150/kansenshogakuzasshi1970.70.821
https://doi.org/10.11150/kansenshogakuzasshi1970.70.821
Autor:
Toshio KISHIMOTO, Yoshifumi KUBOTA, Toshiharu MATSUSHIMA, Hiroshi IZUTSU, Akira MATSUMOTO, Rinzo SOEJIMA, Kei NUMAZAKI, Shunzo CHIBA, Tsutomu YAMAZAKI, Nozomu SASAKI, Mitsuo KAKU, Jingoro SHIMADA, Eisaku IWASAKI, Minoru BABA, Yoshiaki KOORI, Masanori AIHARA, Hiroki CHIKUMI, Satoru KOSABA, Yukiko NONAKA, Kazunobu OUCHI, Tetsuro YAMAMOTO, Seizaburo KASHIWAGI, Tomotaka KAWAYAMA, Kohtaro OHIZUMI, Hiroyuki NAGAI, Masaru NASU, Shigeru KOUNO, Hironori TANAKA, Yoichi HIRAKATA, Masao TATEYAMA, Atsushi SAITO
Publikováno v:
Journal of the Japanese Association for Infectious Diseases. 70:830-839
We measured anti-Chlamydia pneumoniae (C. pneumoniae) specific antibody titers by means of a newly-developed enzyme-linked immunosorbent assay (ELISA) method using an anti-C. pneumoniae specific antibody detection reagent. The clinical usefulness of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b969c16f046055b02444a17c7d978069
https://doi.org/10.11150/kansenshogakuzasshi1970.70.830
https://doi.org/10.11150/kansenshogakuzasshi1970.70.830
Autor:
Alexei Protopopov, Kazuaki Takabe, Toshifumi Wakai, Takashi Kobayashi, Yoshifumi Shimada, Ruobai Sun, Mitsutaka Nakada, Nobuaki Sato, Meaghan Russell, Jennifer E. Ring, Jun Sakata, Masayuki Nagahashi, Keisuke Kodama, Hiroshi Ichikawa, Joerg Heyer, Shujiro Okuda, Hitoshi Kameyama, Stephen Lyle, Hiroshi Izutsu, Winslow Powers
Publikováno v:
Journal of Clinical Oncology. 34:e15121-e15121
e15121Background: The advent of whole genomic sequencing has greatly facilitated the identification and characterization of cancer-relevant genes. Given the potential genetic and environmental diff...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30352914d7b1fe7d2b532f86420bcba4
https://doi.org/10.1200/jco.2016.34.15_suppl.e15121
https://doi.org/10.1200/jco.2016.34.15_suppl.e15121