Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Hiroshi Funakoshi"'
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 3, Pp 133-144 (2018)
Abstract Aim Indoleamine 2,3‐dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP). IDO1 is an initial rate‐limiting enzyme in the K
Externí odkaz:
https://doaj.org/article/1b6105effae146df9e33061c7e79352c
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 2, Pp 52-60 (2018)
Abstract Aims Tryptophan 2,3‐dioxygenase (TDO2) is an initial rate‐limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) metabolism. The Trp‐degrading enzymes, TDO2 and indoleamine 2,3‐dioxygenase, are activated by stress and/or
Externí odkaz:
https://doaj.org/article/4def025a348848eab54db921edde089c
Publikováno v:
Biomedicines, Vol 2, Iss 4, Pp 275-300 (2014)
Hepatocyte growth factor (HGF) is composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. Activation of the HGF–Met pathway evokes dynamic biological responses that s
Externí odkaz:
https://doaj.org/article/62f9f4a669324f228c3ddafe6cf1597d
Autor:
Frank Elbers, Claudia Woite, Valentina Antoni, Sara Stein, Hiroshi Funakoshi, Toshikazu Nakamura, Gereon Schares, Walter Däubener, Silvia K. Eller
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Tryptophan is an essential amino acid for hosts and pathogens. The liver enzyme tryptophan 2,3-dioxygenase (TDO) provokes, by its ability to degrade tryptophan to N-formylkynurenine, the precursor of the immune-relevant kynurenines, direct and indire
Externí odkaz:
https://doaj.org/article/2958d08d232e4dc6a6984adb18343408
Autor:
Kazuya Kitamura, Kanehiro Fujiyoshi, Jun-Ichi Yamane, Fumika Toyota, Keigo Hikishima, Tatsuji Nomura, Hiroshi Funakoshi, Toshikazu Nakamura, Masashi Aoki, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27706 (2011)
Many therapeutic interventions for spinal cord injury (SCI) using neurotrophic factors have focused on reducing the area damaged by secondary, post-injury degeneration, to promote functional recovery. Hepatocyte growth factor (HGF), which is a potent
Externí odkaz:
https://doaj.org/article/94371cabd7c54c53b176ec6c6395f74c
Publikováno v:
International Journal of Molecular Sciences. 24:4778
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9441426cda2161d8854cef1394c956a
https://doi.org/10.3390/ijms24054778
https://doi.org/10.3390/ijms24054778
Autor:
Syunsuke Yasuda, Marino Nagata, Kensuke Oikawa, Akemi Kosaka, Celis Esteban, Yasuaki Harabuchi, Shohei Harabuchi, Hiroya Kobayashi, Takayuki Ohkuri, Mizuho Ohara, Takumi Kumai, Toshihiro Nagato, Jun Ueda, Hiroshi Funakoshi, Yuki Yajima, Ryusuke Hayashi, Kenzo Ohara
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2301-2312
Stimulator of interferon genes (STING) contributes to anti-tumor immunity by activating antigen-presenting cells and inducing mobilization of tumor-specific T cells. A role for tumor-migrating neutrophils in the anti-tumor effect of STING-activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a34589f75de98c79eb580a8ea5323a7
https://doi.org/10.1007/s00262-021-02864-0
https://doi.org/10.1007/s00262-021-02864-0
Publikováno v:
Theriogenology. 144:146-151
In vitro fertilization (IVF) is an established technology that is widely used in reproductive engineering. However, in rats, successful application of IVF is difficult to achieve, and it has had poor reproducibility. In a previous study on the critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cba4348c242c452c83ce45219af5bc
https://doi.org/10.1016/j.theriogenology.2020.01.006
https://doi.org/10.1016/j.theriogenology.2020.01.006
Publikováno v:
Neuropsychopharmacology Reports
Aim Indoleamine 2,3‐dioxygenase 1 (IDO1) metabolizes the essential amino acid tryptophan into kynurenine derivatives, which are involved in neural activity via the kynurenine pathway (KP). IDO1 is an initial rate‐limiting enzyme in the KP and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50efcb1c3cb80065fb6dedf5801de619
http://europepmc.org/articles/PMC7292290
http://europepmc.org/articles/PMC7292290
Publikováno v:
Neuropsychopharmacology Reports
Aims: Tryptophan 2, 3‐dioxygenase (TDO2) is an initial rate‐limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) metabolism. The Trp‐degrading enzymes, TDO2 and indoleamine 2, 3‐dioxygenase, are activated by stress and/or infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c81e7a6a99dac4a42d03ee1b8a192c
https://doi.org/10.1002/npr2.12006
https://doi.org/10.1002/npr2.12006