Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hiroshi Fukase"'
Autor:
Hiroshi Fukase
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 55:920-925
Voglibose (1, N- [2-hydroxy-1- (hydroxymethyl) ethyl] valiolamine, basen®), having more potent disaccharidase inhibitory activity against maltase and sucrase than do naturally occurring pseudo-oligosaccharide α-glucosidase inhibitors, has been deve
Autor:
Satoshi Horii, Hiroshi Fukase
Publikováno v:
The Journal of Organic Chemistry. 57:3642-3650
The synthesis of (1S)-1(OH),2,4/1,3)-2,3,4-tri-O-benzyl-1-C-[(benzyloxy)methyl]-5-oxo--1,2,3,4-cyclohexanetetrol (7), which is an important synthon for the synthesis of valiolamine (8) and its N-substituted derivatives such as AO-128(9) having strong
Autor:
Hiroshi Fukase, Satoshi Horii
Publikováno v:
The Journal of Organic Chemistry. 57:3651-3658
Novel synthetic routes to valiolamine (1a) and N-substituted valiolamine derivatives via branched-chain inosose derivatives are described. (1S)-(1(OH),2,4/1,3)-2,3,4-tri-O-benzyl-1-C- [(benzyloxy)methyl]-5-oxo-1,2,3,4-cyclohexanetetrol (3), a branche
Autor:
Hiroshi Fukase
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 58:485-487
Publikováno v:
The Journal of Antibiotics. 43:1039-1041
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:3601-3611
Chemical degradation and spectral studies on toromycin, an antibiotic isolated from Streptomyces collinus subsp. albescens, showed that toromycin is a polycyclic aromatic hydrocarbon having a C-glycosyl group at C-4, a vinyl group at C-8, two methoxy
Autor:
Hiroshi Fukase, Hidesuke Iwasaki
Publikováno v:
Bulletin of the Chemical Society of Japan. 49:767-770
The C-3 side chain moiety of C-2801X, a new cephamycin-type antibiotic, was almost quantitatively obtained by Dowex 50-catalyzed hydrolysis, and its structure was established as 3,4-dihydroxy-α-methoxycinnamic acid (I) by spectroscopic analyses and
Autor:
Takuji Yamaguchi, Katsuhiko Matsui, Satoshi Horii, Naoki Asano, Yukihiko Kameda, Hiroshi Fukase
Publikováno v:
The Journal of Antibiotics. 39:1491-1494
Publikováno v:
Carbohydrate Research. 60:275-288
Per- N -formylation of aminoglycoside (aminocyclitol) antibiotics followed by mild hydrolysis with aqueous ammonia gave mono- N -deformylated derivatives. Each positional isomer of the mono- N -deformylated derivatives thus obtained was separated by
Publikováno v:
Carbohydrate Research. 140:185-200
Methods are described for the stereoselective conversion of valienamine ( 2 ) and validamine ( 3 ) into valiolamine ( 1a ), a new pseudo-amino sugar isolated from the fermentation broth of Streptomyces hygroscopicus subsp. limoneus and which is a str