Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Hiroshi FUJISAKI"'
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
To computationally investigate the recent experimental finding such that extracellular ATP release caused by exogeneous mechanical forces promote wound closure, we introduce a mathematical model, the Cellular Potts Model (CPM), which is a popular dis
Externí odkaz:
https://doaj.org/article/66d08e93380d4893bfc49b5fc3defe4c
Publikováno v:
Life, Vol 12, Iss 8, p 1188 (2022)
We apply the non-Markov-type analysis of state-to-state transitions to nearly microsecond molecular dynamics (MD) simulation data at a folding temperature of a small artificial protein, chignolin, and we found that the time scales obtained are consis
Externí odkaz:
https://doaj.org/article/b5bea2f387dc41959cbc545fd8834b6f
Autor:
Yasuhiro Matsunaga, Tsutomu Yamane, Tohru Terada, Kei Moritsugu, Hiroshi Fujisaki, Satoshi Murakami, Mitsunori Ikeguchi, Akinori Kidera
Publikováno v:
eLife, Vol 7 (2018)
The multidrug transporter AcrB transports a broad range of drugs out of the cell by means of the proton-motive force. The asymmetric crystal structure of trimeric AcrB suggests a functionally rotating mechanism for drug transport. Despite various sup
Externí odkaz:
https://doaj.org/article/dd7aafffc56045afa8533fb9230e1ae8
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3177 (2018)
To understand functions of biomolecules such as proteins, not only structures but their conformational change and kinetics need to be characterized, but its atomistic details are hard to obtain both experimentally and computationally. Here, we review
Externí odkaz:
https://doaj.org/article/8e42d20ea9954c3db9f2b70f741994a4
Autor:
Yasuhiro Matsunaga, Hiroshi Fujisaki, Tohru Terada, Tadaomi Furuta, Kei Moritsugu, Akinori Kidera
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002555 (2012)
Large-scale conformational changes in proteins involve barrier-crossing transitions on the complex free energy surfaces of high-dimensional space. Such rare events cannot be efficiently captured by conventional molecular dynamics simulations. Here we
Externí odkaz:
https://doaj.org/article/ed8c88d948de45e0804293ff7dc641d0
Autor:
Hiroshi FUJISAKI
Publikováno v:
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. :431-439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2743def493f508e978645d87a3ee086
https://doi.org/10.1587/transfun.2022tap0007
https://doi.org/10.1587/transfun.2022tap0007
Autor:
Hiroshi Fujisaki1,2 fujisaki@nms.ac.jp
Publikováno v:
Journal of Nippon Medical School. 2022, Vol. 89 Issue 1, p9-15. 7p.
Publikováno v:
Journal of Chemical Theory and Computation. 17:2522-2529
Pin1 enzyme protein recognizes specifically phosphorylated serine/threonine (pSer/pThr) and catalyzes the slow interconversion of the peptidyl-prolyl bond between cis and trans forms. Structural dynamics between the cis and trans forms are essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578154de3265fea5a074c6595f0f5492
https://doi.org/10.1021/acs.jctc.0c01280
https://doi.org/10.1021/acs.jctc.0c01280
Autor:
Hiroshi Fujisaki
Publikováno v:
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. :757-768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e837c1b78649ad2e345ba8bd527e6a4f
https://doi.org/10.1587/transfun.2019eap1140
https://doi.org/10.1587/transfun.2019eap1140
Autor:
Hiroshi Fujisaki, Kenta Odagiri
Publikováno v:
INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING ICCMSE 2020.
Motivated by the experimental study showing that exogeneous mechanical forces promote wound healing, we introduce a mathematical model for wound healing caused by exogeneous mechanical stimuli. For the dynamics of cells such as movement, growth, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9103e19b2093e39f6da6e48c800988
https://doi.org/10.1063/5.0048360
https://doi.org/10.1063/5.0048360