Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Hiroshi Demura"'
Autor:
Hiromi Hagiwara, Shigehisa Hirose, Chika Adachi, Mitsuhide Naruse, Eri Otsuka, Atsuto Inoue, Kiyoko Naruse, Yoshiharu Hiruma, Hiroshi Demura
Publikováno v:
Journal of Biochemistry. 126:168-173
Ipriflavone (7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one) is a synthetic flavonoid that has been shown to stimulate the activity of osteoblasts. We show here that ipriflavone also promotes the deposition of calcium and the formation of mineralized no
Publikováno v:
Journal of Endocrinology. 161:511-516
Growth hormone (GH) is known to interact with adipose tissue and to induce lipolysis. Adipocytes produce leptin which regulates appetite and energy expenditure. In order to elucidate the role of GH in leptin production, we studied the effect of GH on
Publikováno v:
Endocrine Journal. 46:125-132
Human growth hormone with 22,000 Dal (22K-hGH) stimulates proliferation and differentiation of osteoblasts as well as production of interleukin-6 in vitro and bone formation and remodeling in vivo. To investigate whether hGH isoform with 20Kd (20K-hG
Publikováno v:
Endocrine Journal. 46:S17-S24
In order to identify the mutual interaction between GH and leptin, we studied the effect of GH on fatty Zucker rats. GH administration at a high dose (5.0 IU/kg) reduced % body fat after 7 days. The leptin mRNA level in subcutaneous fat tissue was no
Autor:
M Naruse, Zheng-pei Zeng, S Yamamori, Hiroshi Demura, Toshio Nishikawa, H Matsumoto, Akiyo Tanabe, Takanobu Yoshimoto, T Kasajima, H Toma, K Naruse
Publikováno v:
Journal of Endocrinology. 159:247-255
To explore the clinical significance of p53 in the pathogenesis of adrenal neoplasms, we investigated the incidence of p53 gene mutations in functioning human adrenal tumours using the polymerase chain reaction-single strand conformation polymorphism
Autor:
Takanobu Yoshimoto, Toshiro Seki, Akiyo Tanabe, H Miyazaki, K Naruse, K. Arai, Hiroshi Demura, Masao Kobayashi, Toshihiro Imaki, Mitsuhide Naruse
Publikováno v:
Journal of Endocrinological Investigation. 21:668-672
Angiotensin II (Ang II) type 2 receptor (AT2) has been shown to counteract the type 1 receptor (AT1)-mediated biological actions of Ang II in the cardiovascular system. The biological significance of AT2 receptor in the adrenals however remains unkno
Autor:
Osamu Isozaki, Toshiaki Tanaka, Megumi Miyakawa, Toshio Tsushima, Hitomi Murakami, Hiroshi Demura
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:3476-3479
As leptin, an ob gene product, plays a pivotal role in the regulation of adiposity and energy homeostasis, the level of its expression is likely to fluctuate under various physiological, nutritional, and disease conditions. Reports regarding the effe
Publikováno v:
European Journal of Endocrinology. 139:276-283
In order to investigate the risk factors, pathogenesis and natural course of the osteoporosis frequently seen in anorexia nervosa, we measured the bone mineral density (BMD) of the lumbar spine using dual X-ray absorptiometry in 51 Japanese female pa
Autor:
Mitsuhide Naruse, Akiyo Tanabe, Takanobu Yoshimoto, Kazuo Murakami, Takeshi Sugaya, Toshirou Seki, Kiyoko Naruse, Toshihiro Imaki, Hiroshi Demura, Reiko Demura
Publikováno v:
Life Sciences. 63:1593-1598
The functional significance of angiotensin II (Ang II) receptor subtypes in adrenals remains unknown. Ang II receptor type 1a (AT1a) expression was localized by in situ hybridization to the zona glomerulosa and zona fasciculate, while AT1b was locali
Publikováno v:
Gene. 219:125-130
We determined the genomic organization of human CRF type-1 receptor (hCRF-R1). The gene coding for hCRF-R1 consists of at least 14 exons and spans over 20 kilobases. hCRF-R1's three reported isoforms originate from the same gene by alternative splici