Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Hiroshi Kawano"'
A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis
Autor:
Takeshi Imakura, Seidai Sato, Kazuya Koyama, Hirohisa Ogawa, Takahiro Niimura, Kojin Murakami, Yuya Yamashita, Keiko Haji, Nobuhito Naito, Kozo Kagawa, Hiroshi Kawano, Yoshito Zamami, Keisuke Ishizawa, Yasuhiko Nishioka
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease with few effective therapeutic options. Recently, drug repositioning, which involves identifying novel therapeutic potentials for existing drugs, has been popula
Externí odkaz:
https://doaj.org/article/7057a223cb3045dfa82deb327ea943dc
Autor:
Daiki Watanabe, Yuko Gando, Haruka Murakami, Hiroshi Kawano, Kenta Yamamoto, Akie Morishita, Nobuyuki Miyatake, Motohiko Miyachi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract This study aimed to identify the modifiable cardiovascular risk factors associated with longitudinal changes, which are nine functional and structural biological vascular aging indicators (BVAIs), to propose an effective method to prevent bi
Externí odkaz:
https://doaj.org/article/d155303be133476e961432efc09d043e
Autor:
Takuro Kameda, Keisuke Kataoka, Ayako Kamiunten, Michihiro Hidaka, Hiroaki Miyoshi, Nobuaki Nakano, Kisato Nosaka, Makoto Yoshimitsu, Jun-ichirou Yasunaga, Yasunori Kogure, Kotaro Shide, Masaharu Miyahara, Takashi Sakamoto, Keiichi Akizuki, Tomonori Hidaka, Yoko Kubuki, Junji Koya, Noriaki Kawano, Kiyoshi Yamashita, Hiroshi Kawano, Takanori Toyama, Kouichi Maeda, Kosuke Marutsuka, Yoshitaka Imaizumi, Koji Kato, Takeshi Sugio, Masahito Tokunaga, Yukie Tashiro, Akifumi Takaori-Kondo, Yasushi Miyazaki, Koichi Akashi, Kenji Ishitsuka, Masao Matsuoka, Koichi Ohshima, Toshiki Watanabe, Akira Kitanaka, Atae Utsunomiya, Seishi Ogawa, Kazuya Shimoda
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
The prognosis of aggressive adult T-cell leukemia/lymphoma (ATL) is poor, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment. In order to identify favorable prognostic patients after intensive chemotherapy, and
Externí odkaz:
https://doaj.org/article/a7eec3d00c7d4059bd11e5e0d629a998
Autor:
Shigeo Shimose, Atsushi Hiraoka, Masahito Nakano, Hideki Iwamoto, Masatoshi Tanaka, Takaaki Tanaka, Kazunori Noguchi, Hajime Aino, Kei Ogata, Masahiko Kajiwara, Satoshi Itano, Yoshinori Yokokura, Taizo Yamaguchi, Hiroshi Kawano, Norito Matsukuma, Hideya Suga, Takashi Niizeki, Tomotake Shirono, Yu Noda, Naoki Kamachi, Shusuke Okamura, Takumi Kawaguchi, Hironori Koga, Takuji Torimura
Publikováno v:
Cancer Medicine, Vol 10, Iss 23, Pp 8530-8541 (2021)
Abstract Background and Aims Sequential therapy with molecular‐targeted agents (MTAs) is considered effective for unresectable hepatocellular carcinoma (HCC) patients. This study purposed to evaluate the efficacy of sequential therapy with sorafeni
Externí odkaz:
https://doaj.org/article/0894e9642c0c4631b38c4aa5d3985b9c
Autor:
Julien Tripette, Yuko Gando, Haruka Murakami, Ryoko Kawakami, Kumpei Tanisawa, Harumi Ohno, Kana Konishi, Michiya Tanimoto, Noriko Tanaka, Hiroshi Kawano, Kenta Yamamoto, Akie Morishita, Motoyuki Iemitsu, Kiyoshi Sanada, Nobuyuki Miyatake, Motohiko Miyachi
Publikováno v:
BMC Sports Science, Medicine and Rehabilitation, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background In an effort to increase people’s adherence to active lifestyles, contemporary physical activity (PA) guidelines now include low-dose PA. Methods PA was evaluated in 583 participants of the Nutritional and Physical Activity Inte
Externí odkaz:
https://doaj.org/article/74f4f984b00b4bca925e161bb95ebcc9
Autor:
Hiroshi Kawano, Kazuya Koyama, Haruka Nishimura, Yuko Toyoda, Kozo Kagawa, Seidai Sato, Nobuhito Naito, Hisatsugu Goto, Yutaka Inagaki, Yasuhiko Nishioka
Publikováno v:
Immunity, Inflammation and Disease, Vol 9, Iss 1, Pp 120-127 (2021)
Abstract Introduction Fibrocytes are emerging myeloid‐derived circulating cells that can migrate into damaged tissues and usually contribute to their repair. Key features of fibrocytes include the expression myeloid markers, production of extracell
Externí odkaz:
https://doaj.org/article/cdd4007fc96349ecb3ca78bae2e67825
Autor:
Kozo Kagawa, Seidai Sato, Kazuya Koyama, Takeshi Imakura, Kojin Murakami, Yuya Yamashita, Nobuhito Naito, Hirohisa Ogawa, Hiroshi Kawano, Yasuhiko Nishioka
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275987 (2022)
BackgroundLymphocyte-specific protein tyrosine kinase (Lck) is a member of the Src family of tyrosine kinases. The significance of Lck inhibition in lung fibrosis has not yet been fully elucidated, even though lung fibrosis is commonly preceded by in
Externí odkaz:
https://doaj.org/article/881c1c87d0224f0c83fe54514edb7cd3
Autor:
Takuro Kameda, Kotaro Shide, Yuki Tahira, Masaaki Sekine, Seiichi Sato, Junzo Ishizaki, Masanori Takeuchi, Keiichi Akizuki, Ayako Kamiunten, Haruko Shimoda, Takanori Toyama, Kouichi Maeda, Kiyoshi Yamashita, Noriaki Kawano, Hiroshi Kawano, Tomonori Hidaka, Hideki Yamaguchi, Yoko Kubuki, Akira Kitanaka, Hitoshi Matsuoka, Kazuya Shimoda
Publikováno v:
Viruses, Vol 14, Iss 4, p 710 (2022)
A retrospective chart survey of the clinical features of indolent adult T-cell leukemia/lymphoma (ATL) was conducted in the Miyazaki Prefecture, Japan. This study enrolled 24 smoldering-type ATLs, 10 favorable chronic-type ATLs, and 20 unfavorable ch
Externí odkaz:
https://doaj.org/article/1d71424fea5e4ebebf48053a89732254
Autor:
Seidai Sato, Shintaro Shinohara, Shinya Hayashi, Shun Morizumi, Shuichi Abe, Hiroyasu Okazaki, Yanjuan Chen, Hisatsugu Goto, Yoshinori Aono, Hirohisa Ogawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Yuko Toyoda, Hisanori Uehara, Yasuhiko Nishioka
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been
Externí odkaz:
https://doaj.org/article/a844590c917a47219ecc7e5a1ef46e98
Autor:
Taishi Furushima, Motohiko Miyachi, Motoyuki Iemitsu, Haruka Murakami, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Kiyoshi Sanada
Publikováno v:
Journal of Physiological Anthropology, Vol 36, Iss 1, Pp 1-9 (2017)
Abstract Background This study aimed to develop and cross-validate prediction equations for estimating appendicular skeletal muscle mass (ASM) and to examine the relationship between sarcopenia defined by the prediction equations and risk factors for
Externí odkaz:
https://doaj.org/article/10b1d379eab64c5d9fcaab90c4d493e4