Significance of Vascular Dipeptidyl Peptidase-4 Inhibition on Vascular Protection in Zucker Diabetic Fatty Rats

Autor: Shinji Takai, Hiroshi Sakonjo, Denan Jin

Publikováno v: Journal of Pharmacological Sciences, Vol 125, Iss 4, Pp 386-393 (2014)

Abstract.: To clarify the role of dipeptidyl peptidase-4 (DPP-4) inhibition in vascular tissues, we compared the effects of the poorly tissue-penetrative DPP-4 inhibitor sitagliptin to the highly tissue-penetrative DPP-4 inhibitor linagliptin in Zuck

Externí odkaz: https://doaj.org/article/30569bcc7b1246eba2047f51e1c0470a

Outside Fibroblasts Play a Key Role in the Development of Inner Neointima After the Implantation of Polytetrafluoroethylene Grafts

Autor: Denan Jin, Shinji Takai, Zhonglian Li, Hiroshi Sakonjo, Yoshinori Otsuki, Yuro Shibayama, Mizuo Miyazaki

Publikováno v: Journal of Pharmacological Sciences, Vol 119, Iss 2, Pp 139-149 (2012)

The neointima formation inside of polytetrafluoroethylene (PTFE) grafts may be associated with the migration of outside fibroblasts to the luminal surfaces. This study aimed to verify whether blockade of fibroblast migration can prevent neointima for

Externí odkaz: https://doaj.org/article/1b76f6649ee54a12920350de6eb6a69f

Contents Vol. 99, 2017

Autor: Akira Oita, Josué A. Velázquez-Moyado, Mohamed Habib Grissa, Zhi Dong, Nizar Fredj, Adel Sekma, Adelfo Reyes-Ramírez, Takayo Haruna, Kaoru Ogawa, Tin Sandar Zaw, Hiiragi Sugo, Semir Nouira, Wen-Bin Wu, Katsuaki Dan, Hiroshi Sakonjo, Juan Carlos Castillo-Hernández, Martín González-Andrade, Mi Tang, Kinichi Imura, Tomio Okamura, Jun Hayakawa, Masashi Deguchi, Yuka Terada, Menglin Rao, Kamel Monastiri, Haruka Saeki, Uy Dong Sohn, Takashi Shimosato, Hideki Hasegawa, Akinori Arimura, Yasuhide Morioka, Chi Zhang, Mitsutaka Takada, Elena G. Ramírez-López, Emna Kerkeni, Malek Mzali, Kohei Wakitani, Kyoichi Wada, Saki Hiruma, Yuichi Uwai, Tsong-Long Hwang, Takaya Miyazaki, Yujie Cheng, Jihua Ma, Fumiko Sekiguchi, Phyu Phyu Khin, Keita Takanashi, Nejia Tounsi, Sho Kanzaki, Huey-Ming Lo, Masashi Matsumoto, Jie Hao, Junlian Xing, Wanzhen Jiang, Druckerei Stückle, Masashi Tawa, Yoshinori Funakami, Wahiba Douki, Kenji Watanabe, Zhipei Liu, Maho Tsubota, Yoko Furue, Tomoyoshi Miyamoto, Imen Trabelsi, Atsufumi Kawabata, Mina Yamamoto, Kiyoshi Yasui, Sha Liu, Ilhem Hellara, Andrés Navarrete, Peihua Zhang, Xinrong Fan, Masahiko Soga, Antao Luo, Tomohiro Nabekura, Tatsuya Kawasaki

Publikováno v: Pharmacology. 99:I-IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd7224023f225c4f99f2ba4efdd7bdb8
https://doi.org/10.1159/000471495

Responsiveness of Coronary Arteries to Nitroglycerin under Hypoxia: The Importance of the Endothelium

Autor: Takashi Shimosato, Tomio Okamura, Masashi Tawa, Hiroshi Sakonjo

Publikováno v: Pharmacology. 99(5-6)

Background/Aims: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact and -denuded rabbit, monke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc5f8160fb147dca2d3e08fdcd68cdc
https://pubmed.ncbi.nlm.nih.gov/28249288

Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats

Autor: Takashi Shimosato, Denan Jin, Shinji Takai, Hiroshi Sakonjo, Mizuo Miyazaki

Publikováno v: Hypertension Research. 34:245-252

The vascular protective effects of placebo, candesartan (1 mg kg(-1) per day) monotherapy, candesartan (1 mg kg(-1) per day) and amlodipine (1 mg kg(-1) per day) combination therapy, and candesartan (1 mg kg(-1) per day) and hydrochlorothiazide (HCTZ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5188e0cb93432e2e55a0cceed324f6da
https://doi.org/10.1038/hr.2010.224