Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection caseResearch in context

Autor: Takeo Kuwata, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Ryuta Uraki, Kyo Okazaki, Rumi Minami, Yoji Nagasaki, Mami Nagashima, Isao Yoshida, Kenji Sadamasu, Kazuhisa Yoshimura, Mutsumi Ito, Maki Kiso, Seiya Yamayoshi, Masaki Imai, Terumasa Ikeda, Kei Sato, Mako Toyoda, Takamasa Ueno, Takako Inoue, Yasuhito Tanaka, Kanako Tarakado Kimura, Takao Hashiguchi, Yukihiko Sugita, Takeshi Noda, Hiroshi Morioka, Yoshihiro Kawaoka, Shuzo Matsushita, Jumpei Ito, Naoko Misawa, Arnon Plianchaisuk, Ziyi Guo, Alfredo Hina, Jr., Keiya Uriu, Kaoru Usui, Wilaiporn Saikruang, Spyridon Lytras, Ryo Yoshimura, Shusuke Kawakubo, Luca Nishimura, Yusuke Kosugi, Shigeru Fujita, Luo Chen, Jarel Elgin M. Tolentino, Lin Pan, Wenye Li, Maximilian Stanley Yo, Kio Horinaka, Mai Suganami, Adam P. Strange, Mika Chiba, Keiko Iida, Naomi Ohsumi, Kaho Okumura, Shiho Tanaka, Eiko Ogawa, Kyoko Yasuda, Tsuki Fukuda, Rina Osujo, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Hayato Ito, Keita Matsuno, Hirofumi Sawa, Naganori Nao, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Zannatul Ferdous, Kenji Shishido, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shuhei Tsujino, So Nakagawa, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kayoko Nagata, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Hisano Yajima, Yoshitaka Nakata, Hiroki Futatsusako, Takashi Irie, Ryoko Kawabata, Kaori Tabata, Hesham Nasser, Ryo Shimizu, MST Monira Begum, Michael Jonathan, Yuka Mugita, Otowa Takahashi, Kimiko Ichihara, Chihiro Motozono, Sharee Leong, Akatsuki Saito, Maya Shofa, Yuki Shibatani, Tomoko Nishiuchi, Hiroyuki Asakura, Jiri Zahradnik, Prokopios Andrikopoulos, Miguel Padilla-Blanco, Aditi Konar

Publikováno v: EBioMedicine, Vol 110, Iss , Pp 105439- (2024)

Summary: Background: Emergence of SARS-CoV-2 variants that escape neutralising antibodies hampers the development of vaccines and therapeutic antibodies against SARS-CoV-2. IGHV3-53/3-66-derived public antibodies, which are generally specific to the

Externí odkaz: https://doaj.org/article/e91f95c836a440f4825df3e5b712b6d7

Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan

Autor: Keisuke Oka, Akane Matsumoto, Nobuyuki Tetsuka, Hiroshi Morioka, Mitsutaka Iguchi, Nobuhisa Ishiguro, Tsunehisa Nagamori, Satoshi Takahashi, Norihiro Saito, Koichi Tokuda, Hidetoshi Igari, Yuji Fujikura, Hideaki Kato, Shinichiro Kanai, Fumiko Kusama, Hiromichi Iwasaki, Kazuki Furuhashi, Hisashi Baba, Miki Nagao, Masaki Nakanishi, Kei Kasahara, Hiroshi Kakeya, Hiroki Chikumi, Hiroki Ohge, Momoyo Azuma, Hisamichi Tauchi, Nobuyuki Shimono, Yohei Hamada, Ichiro Takajo, Hirotomo Nakata, Hideki Kawamura, Jiro Fujita, Tetsuya Yagi

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 29, Iss , Pp 247-252 (2022)

ABSTRACT: Objectives: The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is of great concern. We clarified the risk factors underlying CRE infection mortality in Japan. Methods: We conducted a retrospective, multicent

Externí odkaz: https://doaj.org/article/e2de148b602d4c1baae3c1e0d770b774

A Cost-Effective Immobilization Method for MBP Fusion Proteins on Microtiter Plates Using a Gelatinized Starch–Agarose Mixture and Its Application for Convenient Protein–Protein Interaction Analysis

Autor: Yuri Emoto, Ryoya Katayama, Emi Hibino, Sho Ishihara, Natsuko Goda, Takeshi Tenno, Yoshihiro Kobashigawa, Hiroshi Morioka, Hidekazu Hiroaki

Publikováno v: Methods and Protocols, Vol 6, Iss 3, p 44 (2023)

The detection and quantification of protein–protein interactions (PPIs) is a crucial technique that often involves the use of recombinant proteins with fusion protein tags, such as maltose-binding protein (MBP) and glutathione-S-transferase (GST).

Externí odkaz: https://doaj.org/article/ff5d59e96c6b4305a66a0bee55119b82

TIFAB regulates the TIFA-TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA.

Autor: Teruya Nakamura, Chiaki Ohyama, Madoka Sakamoto, Tsugumasa Toma, Hiroshi Tateishi, Mihoko Matsuo, Mami Chirifu, Shinji Ikemizu, Hiroshi Morioka, Mikako Fujita, Jun-ichiro Inoue, Yuriko Yamagata

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 3/12/2024, Vol. 121 Issue 11, p1-7, 13p

Nonlinear ICA of fMRI reveals primitive temporal structures linked to rest, task, and behavioral traits

Autor: Hiroshi Morioka, Vince Calhoun, Aapo Hyvärinen

Publikováno v: NeuroImage, Vol 218, Iss , Pp 116989- (2020)

Accumulating evidence from whole brain functional magnetic resonance imaging (fMRI) suggests that the human brain at rest is functionally organized in a spatially and temporally constrained manner. However, because of their complexity, the fundamenta

Externí odkaz: https://doaj.org/article/15de66a2dec8447badb6fe71df2e8f9f