Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hiroshi, Mineshima"'
Autor:
Hiroshi Mineshima, Hiroki Kimoto, Masaya Hitomi, Fumika Akizawa, Yui Terayama, Tsuyoshi Yoshikawa
Publikováno v:
Congenital anomaliesREFERENCES. 62(3)
Evaluation of learning and memory is crucial in juvenile animal toxicity studies (JAS) during the development of CNS active drugs, but there are no currently recommended test methods. We compared the ability of the Morris water maze (MWM) and the Bie
Autor:
Yoshikazu Taketa1 y-taketa@hhc.eisai.co.jp, Hiroshi Mineshima1, Etsuko Ohta1, Kyoko Nakano-Ito1
Publikováno v:
Journal of Toxicological Sciences. Dec2017, Vol. 42 Issue 6, p707-713. 7p.
Publikováno v:
The Journal of Toxicological Sciences. 42:707-713
Ethylene glycol monomethyl ether (EGME), which is widely used in various industrial products, is known for adverse effects on the reproductive system in adult rats. However, the effects of EGME on reproductive development in juvenile rats have not be
Autor:
Shimpei Kajita, Kanata Ibi, Hiromasa Takashima, Toshiki Matsuoka, Yumi Sakai, Yoji Miwa, Mika Senuma, Tohru Uesugi, Masao Horimoto, Tatsuya Shimizu, Michio Fujiwara, Ken-ichi Noritake, Shino Nishizawa, Takayuki Hirano, Makiko Kuwagata, Masayuki Ube, Akihito Yamashita, Yuka Kirihata, Taishi Tateishi, Satoshi Kudo, Ryu-ichi Katagiri, Kaoru Yabe, Sho Tanaka, Takafumi Oota, Hitoshi Hojo, Nao Nakano, Terumasa Taniguchi, Yuko Sakai, Makoto Ema, Hiroshi Mineshima
Publikováno v:
Congenital anomalies. 59(4)
Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also importan
Autor:
Akihiko Hirose, Seiki Matsuo, Hiroaki Hara, Ryota Tanaka, Ryou Fukushima, Ikuo Matsuura, Akihito Yamashita, Makoto Ema, Nao Nakano, Sakiko Fujii, Harutaka Oku, Kunifumi Inawaka, Hiroshi Mineshima, Taishi Tateishi, Ryohei Yokoi, Katsumi Endoh, Mutsuko Hirata-Koizumi, Masato Naya, Nobuhito Hoshino, Yoji Miwa, Hiroko Noyori, Yukari Imai, Kiyoshi Matsumoto, Ikuro Takakura, Yoshihiro Katsumata, Yuko Tominaga, Atsushi Ono, Yoshinori Hosokawa, Kazuhiro Shimomura, Maki Maeda, Toshiki Matsuoka, Hitoshi Hojo, Toshiaki Yamauchi, Tohru Uesugi, Hirohito Kato, Keiichi Itoh, Hiroyuki Izumi, Kaoru Yabe, Hiroshi Inada, Masao Horimoto, Tatsuya Shimizu, Takafumi Ohta, Chizuru Urakawa
Publikováno v:
Congenital Anomalies. 54:150-161
Autor:
Ikuo Matsuura, Keiichi Itoh, Hiroyuki Izumi, Harutaka Oku, Ryota Tanaka, Nao Nakano, Nobuhito Hoshino, Masato Naya, Tohru Uesugi, Kei Shiozawa, Katsumi Endoh, Hitoshi Hojo, Sakiko Fujii, Ken-ichi Noritake, Atsuko Hishikawa, Seiki Matsuo, Kaoru Yabe, Kazuhiro Chihara, Kiyoshi Matsumoto, Akihiro Arima, Yoji Miwa, Makoto Ema, Ayumi Inoue, Hanako Nishizawa, Hiroshi Mineshima, Ikuro Takakura, Hiroshi Inada, Yasumoto Mizoguchi, Maki Maeda, Yoshinori Hosokawa, Yuzo Asano, Hiroaki Aoyama, Masao Horimoto, Hidenori Miyata, Tatsuya Shimizu, Ryohei Yokoi, Kazuhiro Shimomura, Hiroko Noyori, Hiroaki Hara, Hashihiro Higuchi, Toshiaki Yamauchi, Takafumi Ohta
Publikováno v:
Congenital Anomalies. 52:155-161
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, da
Autor:
Chisato Mori, Emiko Kato, Yoshiharu Matsuno, Tetsuya Fukuta, Keiji Uchida, Toyohiko Aoki, Hiroshi Mineshima
Publikováno v:
Journal of Applied Toxicology. 32:98-107
Azole derivatives have teratogenic effects in rodents. In the present study, malformations and their sensitive windows induced by high-dose ketoconazole (KCZ), an azole derivative, without maternal toxicity were investigated. In addition, the malform
Autor:
Tetsuya Fukuta, I. Shiraishi, C. Kojima, E. Kato, Yasuyuki Okuda, Keiji Uchida, Toyohiko Aoki, Kazuyuki Hirano, T. Horiba, Naruo Katsutani, M. Maeda, T. Hirose, T. Dodo, Hiroshi Mineshima
Publikováno v:
Human & Experimental Toxicology. 29:439-450
Skeletal changes induced by treatment of pregnant rats with four potent teratogens, busulfan, acetazolamide, vitamin A palmitate, and ketoconazole, were evaluated using Alizarin Red S and Alcian Blue double-staining to investigate the relationship be
Autor:
Toyohiko Aoki, Kazuyuki Hirano, Tetsushi Dodo, Naruo Katsutani, Hiroshi Mineshima, Fumihiro Okada, Yasuyuki Okuda, Keiji Uchida, Tetsuya Fukuta
Publikováno v:
Regulatory Toxicology and Pharmacology. 54:308-313
Acetylsalicylic acid (ASA) at single doses of 125, 250, and 500 mg/kg was administered to pregnant rats on Gestation Day (GD) 10, and skeletal changes in fetuses harvested on GD 20 and pups on post-natal (PN) Day 21 were evaluated. Changes in cartila
Autor:
Yoshihito Asada, Hiroshi Mineshima, Kazuyuki Hiratsuka, Hiroto Kawashita, Junji Kuroda, Satoko Tomioka, Mizuno Tani, Tadanori Suzuki, Yukimi Muguruma, Yusuke Nagae, Masahide Kondo
Publikováno v:
The Journal of Toxicological Sciences. 25:51-62
Doses of 0, 30 and 60 mg/kg/day of fadrozole hydrochloride (Afema: non-steroidal aromatase inhibitor, antitumor agent) were given perorally by gavage to HanIbm WIST male rats from 6 or 8 weeks of age for 2 weeks, and from 6 weeks of age for 4 weeks.