Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Hiroshi, Komazaki"'
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Akademický článek
Nemolizumab Improves Patient-Reported Symptoms of Atopic Dermatitis with Pruritus: Post Hoc Analysis of a Japanese Phase III Randomized Controlled Trial
Autor: Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki, Makoto Kawashima, The Nemolizumab-JP01 Study Group
Publikováno v: Dermatology and Therapy, Vol 13, Iss 4, Pp 997-1011 (2023)
Abstract Introduction Atopic dermatitis (AD), with its signs and symptoms of pruritus, dryness, and erythema, severely reduces the quality of life (QOL) of affected patients. We investigated the impact of nemolizumab 60 mg on QOL in Japanese patients
Externí odkaz: https://doaj.org/article/0a6531ebcb694a83911713b2c78fabe9
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2
Multiply Robust Weighted Generalized Estimating Equations for Incomplete Longitudinal Binary Data Using Empirical Likelihood
Autor: Hiroshi Komazaki, Masaaki Doi, Naohiro Yonemoto, Tosiya Sato
Publikováno v: Statistics in Biopharmaceutical Research. :1-14
In clinical trials, missing data may lead to serious misinterpretation of trial results. To address this issue, it is important to collect post-randomization data (such as efficacy measurement data and adverse event onset data). Such post-randomizati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0226657e6941f291cc72fb29249a273
https://doi.org/10.1080/19466315.2023.2191990
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4
Single-Dose, Patient-Initiated Amenamevir Therapy for Recurrent Genital Herpes: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study
Autor: Makoto, Kawashima, Shinichi, Imafuku, Kosuke, Fujio, Hiroshi, Komazaki
Publikováno v: Open Forum Infectious Diseases. 9
Background Amenamevir is a helicase-primase inhibitor with novel mechanisms of antiherpetic action. A patient-initiated single-dose regimen showed clinical efficacy for genital herpes in a phase 2 study. Methods In this phase 3 study, adult immunocom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a554a440f68b598b3000781f2df9cd03
https://doi.org/10.1093/ofid/ofac494
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5
A phase 3, randomized, double-blind, placebo-controlled study evaluating a single, patient-initiated dose of amenamevir for recurrent herpes labialis
Autor: Makoto Kawashima, Daisuke Watanabe, Kosuke Fujio, Hiroshi Komazaki
Publikováno v: The Journal of dermatologyREFERENCES.
Amenamevir (ASP2151), a novel, non-nucleoside analog, antiviral drug, inhibits the enzyme activities of helicase and primase, which are essential for replication of herpes viral genomic DNA. In this phase 3, randomized, double-blind, placebo-controll
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd55a33bfdc8cd001ef1be5fda4cc7b
https://pubmed.ncbi.nlm.nih.gov/36353762
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6
Akademický článek
Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization
Autor: Shigeru Hishinuma, Yuko Sato, Yusuke Kobayashi, Hiroshi Komazaki, Masaki Saito
Publikováno v: Journal of Pharmacological Sciences, Vol 107, Iss 1, Pp 66-79 (2008)
We evaluated changes in the binding properties of sedative and non-sedative histamine H1–receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells. Internalization of H1 receptors was induced without
Externí odkaz: https://doaj.org/article/0e9bfa6cbcc74e369b3f6be5f1e78c71
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7
Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus
Autor: Kenji, Kabashima, Takayo, Matsumura, Hiroshi, Komazaki, Makoto, Kawashima, Taeko, Yoshikawa
Publikováno v: The New England journal of medicine. 383(2)
Nemolizumab is a subcutaneously administered humanized monoclonal antibody against interleukin-31 receptor A, which is involved in pruritus and inflammation in atopic dermatitis. In phase 2 studies, nemolizumab lessened the severity of atopic dermati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc129f4048a503765632fa830e4cbaf
https://pubmed.ncbi.nlm.nih.gov/32640132
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8
Ca2+-dependent down-regulation of human histamine H1receptors in Chinese hamster ovary cells
Autor: Hirokazu Hatahara, Masaru Shoji, Hayato Tsukamoto, Hiroshi Komazaki, Shigeru Hishinuma, Hiroyuki Fukui
Publikováno v: Journal of Neurochemistry. 144:68-80
Gq/11 protein-coupled human histamine H1 receptors in Chinese hamster ovary cells stimulated with histamine undergo clathrin-dependent endocytosis followed by proteasome/lysosome-mediated down-regulation. In this study, we evaluated the effects of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f55abebccdc5f6177ce699712a192339
https://doi.org/10.1111/jnc.14245
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10
Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells
Autor: Masaru Shoji, Hiroyuki Fukui, Hiroshi Komazaki, Shigeru Hishinuma
Publikováno v: Journal of Neurochemistry. 113:990-1001
We investigated the regulatory pathways responsible for agonist-induced internalization and down-regulation of G(q) protein-coupled histamine H(1)-receptors in Chinese hamster ovary cells. Histamine-induced internalization and down-regulation of H(1)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0861c02d6bf611c4e14741685fbf5f96
https://doi.org/10.1111/j.1471-4159.2010.06669.x
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