Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Hiroshi, Koike"'
Autor:
Akari Kusamoto, Miyuki Harada, Ayaka Minemura, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Nanoka Sakaguchi, Jerilee M. K. Azhary, Hiroshi Koike, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Chisato Kunitomi, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The gut microbiome is implicated in the pathogenesis of polycystic ovary syndrome (PCOS), and prenatal androgen exposure is involved in the development of PCOS in later life. Our previous study of a mouse model of PCOS induced by prenatal dihydrotest
Externí odkaz:
https://doaj.org/article/90b5c734052349d09fdd929a2b8053ed
Autor:
Tomohisa Sakai, Yoshihiro Nishida, Kan Ito, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Shiro Imagama
Publikováno v:
Cancer Medicine, Vol 12, Iss 5, Pp 5245-5254 (2023)
Abstract Background The treatment of choice for desmoid‐type fibromatosis (DF) has been changed to active surveillance (AS). However, few studies have reported clinical outcomes of AS modality in Asian countries. This study aimed to clarify the sig
Externí odkaz:
https://doaj.org/article/d9bae89dae3540f38028861057163130
Autor:
Zixin Xu, Nozomi Takahashi, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Tsurugi Tanaka, Nanoka Sakaguchi, Yoko Urata, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17193 (2023)
Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the piv
Externí odkaz:
https://doaj.org/article/5b81eeecfffb4dfe90dfd6c5fc5ef536
Autor:
Kan Ito, Yoshihiro Nishida, Shunsuke Hamada, Koki Shimizu, Tomohisa Sakai, Bisei Ohkawara, Benjamin A. Alman, Atsushi Enomoto, Kunihiro Ikuta, Hiroshi Koike, Jiarui Zhang, Kinji Ohno, Shiro Imagama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against
Externí odkaz:
https://doaj.org/article/b103c9d9c681484a9d7276bc4c0c3415
Autor:
Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Jerilee M. K. Azhary, Nozomi Takahashi, Yoko Urata, Yutaka Osuga
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women, affecting up to 15% of women in this group, and the most common cause of anovulatory infertility. Although its etiology remains unclear, recent resea
Externí odkaz:
https://doaj.org/article/78254a89a6ed46cda49a8549473da9a6
Autor:
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Lisheng Zhuo, Kan Ito, Kunihiro Ikuta, Tomohisa Sakai, Shiro Imagama
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12422 (2023)
This study aimed to clarify the effects of ipriflavone, which effectively reduces KIAA1199 activity, on osteoarthritis (OA) development and progression in an in vivo OA mouse model. The OA model mice were divided into the ipriflavone (200 mg/kg/day)
Externí odkaz:
https://doaj.org/article/b578f9ca63cc4ee99b30cb0962c1dd71
Autor:
Yoshihiro Nishida, Shunsuke Hamada, Tomohisa Sakai, Kan Ito, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Shiro Imagama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The mainstay of treatment for desmoid has been shifted to active surveillance (AS). However, surgery is still being performed on abdominal wall desmoid with a wide surgical margin. The purposes of this study are to clarify the treatment resu
Externí odkaz:
https://doaj.org/article/bb8cc918e08145e3b56e847b29781fce
Autor:
Kan Ito, Yoshihiro Nishida, Kunihiro Ikuta, Hiroshi Urakawa, Hiroshi Koike, Tomohisa Sakai, Jiarui Zhang, Yoshie Shimoyama, Shiro Imagama
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Hyaluronan (HA) has been shown to play important roles in the growth, invasion, and metastasis of malignant tumors. KIAA1199, which has potent HA-degrading activity, has been reported to be expressed in various malignancies and as
Externí odkaz:
https://doaj.org/article/52816bdd664c4c28b1581a2cfa07ee2c
Publikováno v:
World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-6 (2020)
Abstract Background Myxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease. Case presentation A 40-year-old
Externí odkaz:
https://doaj.org/article/33fa7f0f3d1e4102adb56c8d0b7560ed
Autor:
Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Chisato Kunitomi, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Emi Nose, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Kaori Koga, Yutaka Osuga
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1037 (2022)
Endoplasmic reticulum (ER) stress activated in granulosa cells contributes to the pathophysiology of polycystic ovary syndrome (PCOS). In addition, recent studies have demonstrated that Notch signaling plays multiple roles in the ovary via cell-to-ce
Externí odkaz:
https://doaj.org/article/e1a80321abd14e4882d8719f65827c56